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J. J. M. DE VIJLDER, W. F. VAN VOORTHUIZEN, J. E. VAN DIJK, A. RIJNBERK, W. H. H. TEGELAERS, Hereditary Congenital Goiter with Thyroglobulin Deficiency in a Breed of Goats, Endocrinology, Volume 102, Issue 4, 1 April 1978, Pages 1214–1222, https://doi.org/10.1210/endo-102-4-1214
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Hereditary congenital goiter occurring in an inbred breed of goats is reported. The goitrous goats were severely hypothyroid. Thyroglobulin-related antigens could only be detected by radioimmunoassay in amounts of 0.03% of the total protein concentration in the 105,000 X g supernate of the goitrous gland, which corresponded with 8 μg soluble thyroglobulin-related antigens/g tissue. After treatment with digitonin, 4 μg thyroglobulin-related antigens/g tissue could be extracted from the sediment. This means that the gland contained about 12 μg thyroglobulin-related antigens/g tissue (normal about 100 mg/g). However, no thyroglobulin (19S) could be detected by ultracentrifugation experiments, immunodiffusion, or immunoelectrophoresis. Iodinated proteins with sedimentation constants of 3-9S were found. Among these iodinated macromolecular compounds, iodinated “albumin” and some non-hydrolysable iodinated material was found. These last mentioned components were also found in the blood, indicating a leakage from the gland. As described for comparable cases, these results indicate a defect in thyroglobulin synthesis or its regulation. (Endocrinology102: 1214, 1978)