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Sabina Lewicka, Katharina Bige, Kurt Weindel, Jeanette Winter, Wolfgang Pies, Paul Vecsei, Production of 21-deoxyaldosterone by rat adrenal tissue in vitro; evidence for an alternative biosynthetic pathway of aldosterone, Acta Endocrinologica, Volume 123, Issue 2, Aug 1990, Pages 225–230, https://doi.org/10.1530/acta.0.1230225
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Abstract
Quartered rat adrenal glands transformed labelled 21-deoxyaldosterone into aldosterone in vitro. 21-deoxyaldosterone was released from the quartered rat adrenals in vitro in amounts 10 times lower than those of aldosterone and 18-hydroxycorticosterone. The production of all three steroids was qualitatively dependent on the same regulatory elements (electrolytes, ACTH, exogenous precursors, zonal specificity). However, quantitative differences could be observed. The results support a role for 21-deoxyaldosterone as a facultative precursor of aldosterone and indicate that the regulation of its production shows similarities to that of aldosterone.