Beginning with this issue of the print edition of Endocrine Reviews, we introduce a new cover design and improved format of content that match the vitality of the published reviews within. An eye-catching cover design highlights each issue, while internal changes include more pleasing fonts, redesigned pages, increased use of color, and professionally-prepared illustrations. The quality of the illustrations reflects refinements by our professional illustrators, working with the figures submitted by authors. The illustrations are available for download from the online edition of the journal and are suitable for use in presentations and teaching. The Editors and Publications Staff hope that you will enjoy the fresh new look of Endocrine Reviews.