
Contents
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Optogenetic Approaches Optogenetic Approaches
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The C. elegans Connectome The C. elegans Connectome
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Sensory Inputs Sensory Inputs
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Mechanosensation: Neurons and Circuits Mechanosensation: Neurons and Circuits
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Chemosensation Chemosensation
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Chemosensory Molecules Chemosensory Molecules
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Thermosensation Thermosensation
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Learning, Memory, and Decision Making Learning, Memory, and Decision Making
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Motor Outputs Motor Outputs
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The Locomotion Circuit The Locomotion Circuit
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Locomotion Molecules—unc Genes and Their Role in Neuronal Function and Development Locomotion Molecules—unc Genes and Their Role in Neuronal Function and Development
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Egg Laying Egg Laying
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Pharyngeal Pumping Pharyngeal Pumping
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Defecation Defecation
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C. elegans Behavioral States C. elegans Behavioral States
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Closing Remarks Closing Remarks
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References References
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5 Genetics of Behavior in C. elegans
Get accessDenise S. Walker, MRC Laboratory of Molecular Biology, UK
Yee Lian Chew, University of Wollongong and Illawarra Health and Medical Research Institute, Australia
William R. Schafer, MRC Laboratory of Molecular Biology, UK
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Published:05 October 2017
Cite
Abstract
The nematode Caenorhabditis elegans is among the most intensely studied animals in modern experimental biology. In particular, because of its amenability to classical and molecular genetics, its simple and compact nervous system, and its transparency to optogenetic recording and manipulation, C. elegans has been widely used to investigate how individual gene products act in the context of neuronal circuits to generate behavior. C. elegans is the first and at present the only animal whose neuronal connectome has been characterized at the level of individual neurons and synapses, and the wiring of this connectome shows surprising parallels with the micro- and macro-level structures of larger brains. This chapter reviews our current molecular- and circuit-level understanding of behavior in C. elegans. In particular, we discuss mechanisms underlying the processing of sensory information, the generation of specific motor outputs, and the control of behavioral states.
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