
Contents
-
-
-
-
-
-
-
-
Gene Loss and Assembly Errors Gene Loss and Assembly Errors
-
Computational Phylogenetics Computational Phylogenetics
-
Evolution of Synaptic Transmission Evolution of Synaptic Transmission
-
The Earliest Nervous Systems The Earliest Nervous Systems
-
Key Proteins Important for the Evolution of Fast Synaptic Transmission Key Proteins Important for the Evolution of Fast Synaptic Transmission
-
Vesicular Transporters Vesicular Transporters
-
Transporters for Acetylcholine and Biogenic Amines and the SLC18 Family Transporters for Acetylcholine and Biogenic Amines and the SLC18 Family
-
Transporters for Glutamate, Aspartate, and Nucleotides and the SLC17 Family Transporters for Glutamate, Aspartate, and Nucleotides and the SLC17 Family
-
Transporters for GABA and the SLC32 Family Transporters for GABA and the SLC32 Family
-
What Do Transporters Tell Us About Evolution of the Synaptic Vesicle? What Do Transporters Tell Us About Evolution of the Synaptic Vesicle?
-
-
-
The Synaptotagmin Family of Vesicular Ca2+ Sensors The Synaptotagmin Family of Vesicular Ca2+ Sensors
-
Ionotropic Glutamate Receptors Ionotropic Glutamate Receptors
-
Conclusions Conclusions
-
The First Neurotransmitter The First Neurotransmitter
-
Inhibitory Neurotransmission Inhibitory Neurotransmission
-
Gene Diversity and Evolution of Complex Cognitive Processes Gene Diversity and Evolution of Complex Cognitive Processes
-
-
Methods Methods
-
References References
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4 Invertebrate Genomics Provide Insights Into the Origin of Synaptic Transmission
Get accessThomas W. Abrams, Department of Pharmacology, Department of Anesthesiology, and Program in Neuroscience, University of Maryland School of Medicine
Wayne S. Sossin, Montreal Neurological Institute, Canada; McGill University, Canada
-
Published:09 October 2018
Cite
Abstract
During the evolution of synapses, existing molecules were exapted to serve in specific synaptic roles. Recent increased availability of assembled transcriptomes from organisms that evolved before and after the appearance of the earliest synapses provides the opportunity to trace molecular adaptations important for development of fast synaptic transmission. We discuss issues that affect transcriptome assembly and phylogenetic analysis, and which therefore impact this analysis. We use relatively recent transcriptomes of pre-bilaterians to examine the molecular evolution of three types of critical synapse-specific proteins: vesicular transporters, synaptotagmins and ionotropic glutamate receptors. The results emphasize the fundamental difficulties in defining the specific point at which a protein “assumes” a synaptic function. Nevertheless, the analysis informs our understanding of several major evolutionary topics, including the evolution of synaptic vesicles and the identity of the first neurotransmitter used for fast, synchronous transmission. This analysis is also relevant for the current discussion of whether neuronal and synaptic function evolved separately, once in ctenophores and once in cnidarians and the main bilaterian lineage.
Sign in
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Purchase
Our books are available by subscription or purchase to libraries and institutions.
Purchasing informationMonth: | Total Views: |
---|---|
October 2022 | 1 |
December 2022 | 2 |
January 2023 | 2 |
April 2023 | 3 |
May 2023 | 3 |
June 2023 | 2 |
July 2023 | 2 |
September 2023 | 2 |
October 2023 | 3 |
February 2024 | 1 |
March 2024 | 3 |
April 2024 | 2 |
May 2024 | 2 |
June 2024 | 2 |
July 2024 | 2 |
August 2024 | 5 |
September 2024 | 6 |
January 2025 | 2 |
February 2025 | 2 |
March 2025 | 2 |
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.