
Contents
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Introduction Introduction
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Candidate Gene Studies of PTSD Candidate Gene Studies of PTSD
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Dopaminergic System Candidate Gene Studies Dopaminergic System Candidate Gene Studies
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Serotonin System Candidate Gene Studies Serotonin System Candidate Gene Studies
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Alternative Neurobiological System Candidate Gene Studies Alternative Neurobiological System Candidate Gene Studies
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Gene-Environment Interplay in PTSD Gene-Environment Interplay in PTSD
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Epigenetic Studies of PTSD Epigenetic Studies of PTSD
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Gene Expression Studies of PTSD Gene Expression Studies of PTSD
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Analytic Considerations Analytic Considerations
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Control Selection Control Selection
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Trauma Assessment Trauma Assessment
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Developmental Stage and Sex Differences Developmental Stage and Sex Differences
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Conclusion Conclusion
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Future Directions Future Directions
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Note Note
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References References
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11 Genetics and Genomics of Posttraumatic Stress Disorder
Get accessDepartment of Epidemiology, University of Michigan
Psychiatry and Behavioral Sciences, Medical University of South Carolina
Nicole R. Nugent, Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University
Department of Epidemiology, Harvard University
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Published:21 November 2012
Cite
Abstract
PTSD is a complex disorder; a range of molecular features likely contribute to individuals’ increased risk for, or resilience to, developing PTSD when exposed to trauma. This chapter reviews the existing evidence for genetic and other molecular variation that has been tested for association with PTSD in humans. The authors summarize the 30 candidate gene studies of PTSD published to date, as well as the small but growing literature documenting PTSD-associated gene expression, and the emerging evidence of epigenetic variation that underlies this disorder. This review suggests that genetic and genomic variation contributes to PTSD etiology, with effects at times moderated by the environment; however, robust findings are only arrived at through careful attention to appropriate control selection. Future research in this rapidly evolving area should consider the joint action of molecular and environmental features operating at multiple levels to shape risk for PTSD.
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