
Contents
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Conceiving and Designing an fMRI Experiment Conceiving and Designing an fMRI Experiment
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Goals of an fMRI Study Goals of an fMRI Study
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Structure-Function Mapping Structure-Function Mapping
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Process Dissociation and Association Process Dissociation and Association
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Prediction and Psychological Inference Prediction and Psychological Inference
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Design Structure: Kinds of Designs Design Structure: Kinds of Designs
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Practical fMRI Design Practical fMRI Design
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How Many Subjects, and For How Long? Power And Sample Size How Many Subjects, and For How Long? Power And Sample Size
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Powerful Vs. Informative Designs: Making Tradeoffs Powerful Vs. Informative Designs: Making Tradeoffs
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Event-related designs Event-related designs
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Rest intervals and “jitter.” Rest intervals and “jitter.”
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Optimized experimental designs Optimized experimental designs
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Acquiring Data Acquiring Data
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MR Basics MR Basics
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BOLD Signal BOLD Signal
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Arterial Spin Labeling (ASL) Arterial Spin Labeling (ASL)
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Study-Specific Acquisition Choices Study-Specific Acquisition Choices
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Analyzing Data Analyzing Data
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Preprocessing fMRI Data Preprocessing fMRI Data
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Image Reconstruction Image Reconstruction
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Visualization and Artifact Reduction Visualization and Artifact Reduction
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Slice Timing Correction Slice Timing Correction
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Motion Correction Motion Correction
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Co-Registration Co-Registration
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Normalization Normalization
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Smoothing Smoothing
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The General Linear Model The General Linear Model
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GLM model basics GLM model basics
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First-level analysis First-level analysis
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Contrasts Contrasts
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Group analysis Group analysis
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Model-Building Model-Building
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Multiple Comparisons Multiple Comparisons
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Assessing Brain Connectivity Assessing Brain Connectivity
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Conclusions Conclusions
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Note Note
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References References
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6 Essentials of Functional Magnetic Resonance Imaging
Get accessTor D. Wager is a professor in the Department of Psychology at Columbia University in New York, NY.
Martin A. Lindquist is a professor in the Department of Statistics at Columbia University in New York, NY.
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Published:18 September 2012
Cite
Abstract
This chapter provides an introductory overview of functional magnetic resonance imaging (fMRI) study design, analysis, and inference from start to finish. The first section discusses the kinds of questions that fMRI studies can productively answer. The second section discusses issues surrounding data acquisition, including how to choose scanning parameters that are appropriate for the specific scientific questions asked. The third section focuses on fMRI data processing, and the fourth section discusses statistical analysis and inference. The final section discusses how to localize and interpret results, including which kinds of inferences are likely to be valid and which are not.
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