Volume 117, Issue 1, 1 January 2021

Cardiovascular Research Onlife

Spotted by the Scientists of Tomorrow

Clinical Commentaries

Scientists on the Spot

Expert Opinion

Editorials

Position Paper from European Society of Cardiology Working Group

Editor's Choice

Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis

Yvonne Alexander and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 29–42, https://doi.org/10.1093/cvr/cvaa085

• Abstract
• View article
• Supplementary data

Editor's Choice

Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Serena Zacchigna and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 43–59, https://doi.org/10.1093/cvr/cvaa110

• Abstracts
• View article
• Supplementary data

Reviews

Editor's Choice

The effects of sepsis on endothelium and clinical implications

Elena V Dolmatova and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 60–73, https://doi.org/10.1093/cvr/cvaa070

• Abstracts
• View article

Editor's Choice

Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stress

Milton Packer

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 74–84, https://doi.org/10.1093/cvr/cvaa064

• Abstract
• View article

Double trouble: combined cardiovascular effects of particulate matter exposure and coronavirus disease 2019

Vineeta Tanwar and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 85–95, https://doi.org/10.1093/cvr/cvaa293

• Abstract
• View article

Original Articles

Atherosclerosis and lipid biology

Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease

Yasutaka Nakashima and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 96–108, https://doi.org/10.1093/cvr/cvz305

• Abstracts
• View article
• Supplementary data

Editor's Choice

High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolaemia patients

Rafael Escate and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 109–122, https://doi.org/10.1093/cvr/cvaa039

• Abstracts
• View article
• Supplementary data

Cardiac electrophysiology and arrhythmia

RyR2 regulates Cx43 hemichannel intracellular Ca²⁺-dependent activation in cardiomyocytes

Alessio Lissoni and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 123–136, https://doi.org/10.1093/cvr/cvz340

• Abstracts
• View article
• Supplementary data

Inhibition of N-type calcium channels in cardiac sympathetic neurons attenuates ventricular arrhythmogenesis in heart failure

Dongze Zhang and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 137–148, https://doi.org/10.1093/cvr/cvaa018

• Abstracts
• View article
• Supplementary data

Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes

Claire Poulet and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 149–161, https://doi.org/10.1093/cvr/cvaa033

• Abstracts
• View article
• Supplementary data

Cardiac remodelling and heart failure

Nox2⁺ myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1

Michael Molitor and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 162–177, https://doi.org/10.1093/cvr/cvaa042

• Abstracts
• View article
• Supplementary data

NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload

Moritz Schnelle and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 178–187, https://doi.org/10.1093/cvr/cvz331

• Abstract
• View article
• Supplementary data

Cardioprotection

MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling

Brandon Y H Chan and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 188–200, https://doi.org/10.1093/cvr/cvaa017

• Abstracts
• View article
• Supplementary data

Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling

David E Ebeid and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 201–211, https://doi.org/10.1093/cvr/cvaa066

• Abstracts
• View article
• Supplementary data

Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection

Georgios Amanakis and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 212–223, https://doi.org/10.1093/cvr/cvaa053

• Abstracts
• View article

COVID-19

Numbers and phenotype of non-classical CD14^dimCD16⁺ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection

Karin Anne Lydia Mueller and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 224–239, https://doi.org/10.1093/cvr/cvaa328

• Abstracts
• View article
• Supplementary data

Genetics

Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease

Yang Li and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 240–255, https://doi.org/10.1093/cvr/cvz268

• Abstracts
• View article
• Supplementary data

Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells

Tea Kocijan and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 256–270, https://doi.org/10.1093/cvr/cvaa012

• Abstracts
• View article
• Supplementary data

Immunity and inflammation

T-cell senescence accelerates angiotensin II-induced target organ damage

Xiao-Xi Pan and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 271–283, https://doi.org/10.1093/cvr/cvaa032

• Abstracts
• View article
• Supplementary data

Editor's Choice

Effect of inclisiran, the small-interfering RNA against proprotein convertase subtilisin/kexin type 9, on platelets, immune cells, and immunological biomarkers: a pre-specified analysis from ORION-1

Ulf Landmesser and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 284–291, https://doi.org/10.1093/cvr/cvaa077

• Abstract
• View article
• Supplementary data

Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts

Bruna Lima Correa and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 292–307, https://doi.org/10.1093/cvr/cvaa028

• Abstracts
• View article
• Supplementary data

Vascular pathophysiology

Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension

Jing Wu and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 308–319, https://doi.org/10.1093/cvr/cvaa147

• Abstracts
• View article
• Supplementary data

Vascular effects of serelaxin in patients with stable coronary artery disease: a randomized placebo-controlled trial

David Corcoran and others

Cardiovascular Research, Volume 117, Issue 1, 1 January 2021, Pages 320–329, https://doi.org/10.1093/cvr/cvz345

• Abstract
• View article
• Supplementary data

Corrigenda