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GIAN G NERI SERNERI, G MASOTTI, S CASTELLANI, L SCARTI, F TROTTA, M MANNELLI, Role of PGE2 in the modulation of the adrenergic response in man, Cardiovascular Research, Volume 17, Issue 11, November 1983, Pages 662–670, https://doi.org/10.1093/cvr/17.11.662
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SUMMARY
The influence of sympathetic stimulation (SS) (achieved by 2 min cold application) on the plasma concentration of PGE2, PGF2α (radioimmunoassay), noradrenaline (NA) and adrenaline (A) (radioenzymatic assay) and on forearm vascular resistance (indirect measurement, FVR) was studied in 16 healthy volunteers before and after cyclooxygenase inhibition by indomethacin (200 mg per day orally for 3 days) and lysine acetylsalicylate (corresponding to 10 mg·kg−1 of acetylsalicylic acid -ASA- iv). SS induced a sharp increase in PGE2 (from 8.1 ±4.3 pg·ml−1 before SS to 23.9±6.5, P<0.001 2 min after the beginning of SS and then to 18.9± 10.2, P<0.001 to 8.4±3.9, NS, 4and 12 min respectively after the beginning of SS). Plasma levels of PGF2α remained undetectable both before and after SS. The increase in PGE2 was associated with a simultaneous increase in NA (from 13.4±24.2 to 204.1±67.2 pg·ml−1, P<0.001 during SS and 140.6±39.5, NS at the end of the experiment), whereas A did not vary significantly. FVR increased significantly only during SS. ASA did not affect PGE2 and NA plasma levels at rest or after SS. No PGE2 was detected during IND administration either before or after SS.
IND significantly increased NA plasma concentration at the observation made 12 min after the beginning of SS (185.2±64.3 pg·ml−1 vs basal values of 135.9±46.2 pg·ml−1, P<0.05). FVR after SS was found to be higher and remained elevated for a significantly longer period after IND in comparison with the control period and after ASA. These findings indicate that, in man, PGE2 may be involved in modulating the adrenergic response by intervening at the pre-junctional level, probably facilitating the disposal of the neurotransmitter.
