
Contents
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Introduction Introduction
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Purpose of Animal Models Purpose of Animal Models
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Animal Models of Alzheimer’s Dementia Based on the Cholinergic Hypothesis Animal Models of Alzheimer’s Dementia Based on the Cholinergic Hypothesis
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Amyloid Injection Models Amyloid Injection Models
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Transgenic Mouse Models of Amyloidogenesis Transgenic Mouse Models of Amyloidogenesis
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Amyloid Precursor Protein Transgenic Mice Amyloid Precursor Protein Transgenic Mice
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Amyloid Precursor Protein Transgenic Lines Crossed with Other Lines Amyloid Precursor Protein Transgenic Lines Crossed with Other Lines
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Behavioral Changes in Amyloid Precursor Protein Transgenic Mice Behavioral Changes in Amyloid Precursor Protein Transgenic Mice
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Morris Water Maze Morris Water Maze
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Object Recognition Object Recognition
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Fear Conditioning Fear Conditioning
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Radial Arm Water Maze Radial Arm Water Maze
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Other APP-Based Transgenic Models Other APP-Based Transgenic Models
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TAU Depositing Mice TAU Depositing Mice
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Comparisons of Transgenic Mouse Models to Alzheimer’s Disease Comparisons of Transgenic Mouse Models to Alzheimer’s Disease
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Disclosure Disclosure
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References References
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Cite
Abstract
In the discovery phase of drug development for Alzheimer’s disease it is useful to have animal models in which proof of principle can be obtained. Models of disease symptoms (memory impairment) and models of the disease pathology (lesions, amyloid-depositing models, tau-depositing models) are described and discussed. Moreover, these different types of models can be combined in an attempt to more faithfully replicate the disease condition. Although worms, flies, fish and dogs have been explored, the bulk of the research has focused on rodents, especially mice. Each of these approaches has limitations, but all have contributed to the development of agents designed to prevent or treat Alzheimer’s and other dementias.
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