
Contents
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Introduction Introduction
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Prevalence of Resilience Prevalence of Resilience
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Genomics and Resilience Genomics and Resilience
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Epigenetics and Gene Expression Epigenetics and Gene Expression
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The Development of Resilience: Role of Early Life Environment The Development of Resilience: Role of Early Life Environment
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Psychobiological Features of Resilience Psychobiological Features of Resilience
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Traits and Behaviors Traits and Behaviors
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Positive Emotions Positive Emotions
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Positive Cognitive Reappraisal Positive Cognitive Reappraisal
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Purpose in Life Purpose in Life
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Active Coping Styles Active Coping Styles
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Acceptance Acceptance
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Facing Fears Facing Fears
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Humor Humor
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Physical Exercise Physical Exercise
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Social Support Social Support
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Moral Compass: A Set of Guiding Ethical Principles Moral Compass: A Set of Guiding Ethical Principles
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Altruism Altruism
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Neurobiological Profile of Resilience Neurobiological Profile of Resilience
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Corticotropin-Releasing Hormone Corticotropin-Releasing Hormone
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Cortisol Cortisol
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Dehydroepiandrosterone Dehydroepiandrosterone
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The Locus Coeruleus–Norepinephrine System The Locus Coeruleus–Norepinephrine System
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Neuropeptide Y Neuropeptide Y
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Serotonin Serotonin
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The Brain–Gut Axis The Brain–Gut Axis
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Dopamine Dopamine
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Brain-Derived Neurotrophic Factor Brain-Derived Neurotrophic Factor
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Glutamate Glutamate
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Oxytocin Oxytocin
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Endocannabinoids Endocannabinoids
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The Immune System The Immune System
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Neural Circuitry of Reward: How Reward Pathways Impact Resilience to Stress Neural Circuitry of Reward: How Reward Pathways Impact Resilience to Stress
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The Neural Circuitry of Anxiety and Fear: The Role of Fear Learning in Resilience to Stress The Neural Circuitry of Anxiety and Fear: The Role of Fear Learning in Resilience to Stress
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Fear Conditioning Fear Conditioning
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Reconsolidation and Extinction Reconsolidation and Extinction
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Additional Neural Circuitry Relevant in Resilience Additional Neural Circuitry Relevant in Resilience
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Implications for Prevention and Treatment of Stress-Related Psychopathology Implications for Prevention and Treatment of Stress-Related Psychopathology
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Disclosures Disclosures
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References References
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Cite
Abstract
Resilience is the ability to adapt successfully in the face of severe stress, trauma, or adversity. Over the past several decades, a wide range of studies in children and later in adults identified several key psychosocial characteristics associated with resilience, including emotion regulation, cognitive flexibility, positive emotions, and the availability of social support, among others. More recent studies are increasingly employing integrative approaches, incorporating genomic, neuroendocrine, and neuroimaging data to the study of resilience. This chapter reviews our current understanding of the neurobiology of resilience from genomic, developmental, psychosocial, neuroendocrine, brain circuitry, and integrative perspectives, and includes a final section focusing on implications for prevention and treatment of stress-related psychopathology.
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