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Abstract

Motivation

RNA sequencing (RNAseq) is crucial for investigating transcriptional patterns in immunology and vaccine research. However, the analysis of RNAseq data often requires programming skills, which can limit accessibility for researchers lacking such expertise.

Results

We present VaxGO, an intuitive web-based tool designed to facilitate the analysis of differentially expressed genes in the context of immune processes and cells during vaccination. This tool integrates data from Gene Ontology, CellMarker 2.0, the MSigDB Vax collection, and other key studies, including transcriptional atlases of vaccines against COVID-19 and other diseases. VaxGO is an interactive, web-based tool, offering a user-friendly platform for exploring immune responses and vaccine efficacy without programming expertise.

Availability and implementation

The VaxGO tool is available at https://github.com/wapsyed/VaxGO.

Information Accepted manuscripts
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
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© The Author(s) 2025. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Issue Section:
Original Article
Associate Editor: Yoshihiro Yamanishi
Yoshihiro Yamanishi
Associate Editor
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