https://orcid.org/0000-0001-7900-5063
Abstract
Cyclodextrin-based nanoparticles (CDNPs) have shown promise as versatile carriers for improving drug delivery systems. This study investigates the binding constants governing the interaction between paroxetine hydrochloride (PRX) and β-cyclodextrin (βCD) and β-cyclodextrin epichlorohydrin polymer (βCDNP), utilizing a range of methodologies. The findings demonstrate enhanced binding affinity between PRX and βCDNP, offering insights into the binding behavior. Furthermore, the presence of a 2:1 βCD-PRX inclusion complex within the polymer suggests potential applications in drug delivery, particularly for improving solubility and stability of poorly water-soluble drugs. These results contribute to our understanding of host-guest interactions, with implications for enhancing therapeutic efficacy and patient outcomes. The study offers valuable insights into supramolecular chemistry and pharmaceutical sciences, paving the way for more effective drug delivery systems.
The study explores cyclodextrin-based nanoparticles for drug delivery, finding enhanced binding between paroxetine hydrochloride and β-cyclodextrin epichlorohydrin polymer. This suggests applications in improving poorly water-soluble drug solubility and stability, contributing insights to enhance drug delivery systems in pharmaceutical sciences.
