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Katsuyoshi Shibata, Katsuyoshi Urano, Masaki Matsui, A Convenient Synthesis of 3-Cyano-2-methylpyridines under Ultrasonic Irradiation, Bulletin of the Chemical Society of Japan, Volume 61, Issue 6, June 1988, Pages 2199–2200, https://doi.org/10.1246/bcsj.61.2199
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Abstract
Ultrasonic irradiation of α,β-unsaturated carbonyl compounds 1a–i with acetonitrile in the presence of potassium t-butoxide gave 3-cyano-2-methylpyridines 2a–i in moderate to good yields. The pyridines are produced by a Michael reaction of 3-iminobutanonitrile, an acetonitrile dimer, to the substrates 1a–i.
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© 1988 The Chemical Society of Japan
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