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Toshio Fuchigami, Mou-Yung Yeh, Tsutomu Nonaka, Hsien-Ju Tient, Studies of Cyanamide Derivatives. Part 109. A Convenient Method for Preparation of 4-Aminothiazole Compounds from Alkoxythiocarbonylcyanamide Salts, Bulletin of the Chemical Society of Japan, Volume 56, Issue 12, December 1983, Pages 3851–3852, https://doi.org/10.1246/bcsj.56.3851
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Abstract
α-Halo derivatives of ketones, ester, and nitrile reacted readily with potassium ethoxythiocarbonylcyanamide to provide the corresponding 4-amino-2-ethoxythiazole compounds in good yields, while α-halo amide did not. In a similar manner, α,α′-dihalo ketone reacted with 2 equiv of alkoxythiocarbonylcyanamide and S-methyl N-cyanocarbamodithioate salts to give the corresponding bis(4-amino-5-thiazolyl) ketones.