Abstract

α-Halo derivatives of ketones, ester, and nitrile reacted readily with potassium ethoxythiocarbonylcyanamide to provide the corresponding 4-amino-2-ethoxythiazole compounds in good yields, while α-halo amide did not. In a similar manner, α,α′-dihalo ketone reacted with 2 equiv of alkoxythiocarbonylcyanamide and S-methyl N-cyanocarbamodithioate salts to give the corresponding bis(4-amino-5-thiazolyl) ketones.

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