Volume 60, Issue 3, May 2025
Review
The role of cytochrome P4502E1 in ethanol mediated diseases: a narrative update
The activity of cytochrome P450 (CYP2E1) as part of the microsomal ethanol oxidizing system increases following chronic alcohol consumption which results in oxidative stress contributing to alcohol-associated liver disease (AALD) and cancer. CYP2E1 also toxify some drugs and PCs, and decreases retinoic acid. Inhibition of CYP2E1 improves alcoholic liver diseases (ALD) even in humans.
Articles
Identifying responders to gabapentin for the treatment of alcohol use disorder: an exploratory machine learning approach
Brain structural magnetic resonance imaging predictors of brief intervention response in individuals with alcohol use disorder
Evaluating the age of individuals who are seeking treatment for alcohol and substance use disorder in a community-based recovery center
Variables affecting acquisition and maintenance of operant ethanol self-administration in male and female Long-Evans rats
Short summary
Three weeks of intermittent-access two-bottle choice ethanol drinking offers no advantage as an initiation procedure for operant ethanol self-administration over animals that are ethanol-naïve prior to training. In addition, shortening the operant session duration does not always increase overall intake or promote binge-like patterns of intake for either ethanol or sucrose reinforcer.
Web-based interventions for treatment-seeking individuals with hazardous alcohol consumption: analysis of clinical characteristics and motives for abstinence
Short summary
This study compares users and nonusers of the web-based intervention 'Ohne Alkohol mit Nathalie' (OAMN). OAMN primarily attracts well-educated women and is used both as a standalone and complementary tool. OAMN users more frequently reported intrinsic motives for abstinence. Non-OAMN users reported higher AUDIT scores and more psychiatric comorbidities.
Explaining socioeconomic inequalities in alcohol use disorder symptoms: the role of social capital and drinking motives
Effect of acute alcohol consumption in a novel rodent model of decision-making
Problem drinking and comorbidity with mental ill health: a cross-sectional study among healthcare workers in Sweden
This study examined problem drinking and mental health among healthcare workers (HCWs) in Sweden. Problem drinking was found in 3.7% of HCWs, with male nurses and nurse assistants at higher risk. Comorbidity was found between problem drinking and depression but not between problem drinking and burnout.
