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Journal Article
Tekeda F Ferguson and others
Alcohol and Alcoholism, Volume 60, Issue 3, May 2025, agaf019, https://doi.org/10.1093/alcalc/agaf019
Published: 23 April 2025
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Published: 23 April 2025
Figure 1 Odds ratios were determined for PWH having pre-pandemic alcohol misuse on self-reported health-related behaviors during the COVID-19 stay-at-home directive. ( A ) Alcohol misuse increased the odds that participants consumed bread or grains, meat, and salty snacks on most days of the week (≥5 days).
Journal Article
Josefina Peláez-Zuberbuhler and others
Alcohol and Alcoholism, Volume 60, Issue 3, May 2025, agaf016, https://doi.org/10.1093/alcalc/agaf016
Published: 17 April 2025
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Published: 15 April 2025
Figure 1 Overview and general analysis of behavioral tasks. Pre-alcohol non-conflict (a), pre-alcohol conflict (b), and alcohol (c) tasks utilizing the RECORD setup where one of four solutions are dispensed into a bowl surrounded by LED lights per trial (40 trials per session). Setup of the experimental task
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Published: 15 April 2025
Figure 2 Sex differences during acute alcohol task performance. Approach rates for individual sessions for all rats ( n  = 10) in pre-alcohol non-conflict (a) and alcohol (b) tasks, separated by sex. For clarity, 10 representative sessions were randomly selected for visualization. (c) Compared to pre-alcohol
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Published: 15 April 2025
Figure 4 Sex-dependent effects of alcohol observed in proximal tasks. Approach rates for individual sessions for all rats (male = 10, female = 10) in proximal-post-alcohol non-conflict task (a) and distal-post-alcohol non-conflict task (b) separated by sex. For clarity, 10 representative sessions were random
Journal Article
Atanu Giri and others
Alcohol and Alcoholism, Volume 60, Issue 3, May 2025, agaf017, https://doi.org/10.1093/alcalc/agaf017
Published: 15 April 2025
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Published: 15 April 2025
Figure 3 Alcohol affects proximal cost benefit tasks. (a) Psychometric plots of approach rates for individual sessions of rats ( n  = 20) in proximal-post-alcohol non-conflict and proximal-post-alcohol conflict tasks. For clarity, 20 representative sessions were randomly selected for visualization. (b) Psych
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Published: 08 April 2025
Figure 2 Conceptual analytic moderated mediation model.
Journal Article
Karen Schelleman-Offermans and others
Alcohol and Alcoholism, Volume 60, Issue 3, May 2025, agaf012, https://doi.org/10.1093/alcalc/agaf012
Published: 08 April 2025
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Published: 08 April 2025
Graph 1 Probed interaction effect of perceived socio-economic disadvantage with social capital on natural log-transformed alcohol use disorder symptoms in moderation model. Footnote: * P  < .05; ** P  < .01; *** P  < .001.
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Published: 08 April 2025
Graph 4 Probed interaction effect of perceived socio-economic disadvantage with social capital on social motives in moderated mediation analysis. Footnote: * P  < .05; ** P  < .01; *** P  < .001.
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Published: 08 April 2025
Figure 1 Conceptual analytic moderated model.
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Published: 08 April 2025
Graph 2 Probed interaction effect of perceived socio-economic disadvantage with social capital on natural log-transformed coping motives in moderated mediation analysis. Footnote: * P  < .05; ** P  < .01; *** P  < .001.
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Published: 08 April 2025
Graph 3 Probed interaction effect perceived socio-economic disadvantage with social capital on enhancement motives in moderated mediation analysis. Footnote: * P  < .05; ** P  < .01; *** P  < .001.
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Published: 08 April 2025
Graph 5 Probed interaction effect of perceived socio-economic disadvantage with social capital on natural log-transformed conformity motives in moderated mediation analysis. Footnote: * P  < .05; ** P  < .01; *** P  < .001.
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Published: 07 April 2025
Figure 3 Alcohol metabolism and elimination. The major pathway of alcohol metabolism is the oxidative pathway in the liver which involves cytosolic ADH and, at elevated blood alcohol concentrations, CYP2E1, CYP1A2, to produce acetaldehyde, a highly reactive molecule. Acetaldehyde produced by ethanol oxidatio
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Published: 07 April 2025
Figure 6 Role of Cytochrome P4502E1 in ethanol-mediated carcinogenesis ( Seitz et al. 2024 , reproduction with permission). Ethanol induces CYP2E1 which activates a number of PCs to their ultimative carcinogenic metabolites. CYP2E1 also decreases RA resulting in a loss of cell differentiation leading to cell
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Published: 07 April 2025
Figure 2 Ethanol, CYP2E1, and acetaminophen metabolism. Acetaminophen (N-acetyl-p-aminophenol, APAP) is metabolized by CYP2E1 to generate the highly reactive electrophile, NAPQI, which is effectively captured under normal conditions by GSH and is cleared by biliary excretion. However, ingestion of a large do
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Published: 07 April 2025
Figure 4 CYP2E1 and metabolism of xenobiotics. CYP2E1 can metabolize a variety of substances including alcohol (to form acetaldehyde and ROS) which causes LPO and formation of MDA and 4-HNE. In addition CYP2E1 can metabolize procarcinogens to carcinogens; medications to harmless or harmful metabolites; halog