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High-Impact Research from Virus Evolution

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Explore a collection of the most read and most cited articles making an impact in Virus Evolution published within the past two years. This collection will be continuously updated with the journal's leading articles so be sure to revisit periodically to see what is being read and cited.

Also discover the articles being discussed the most on digital media by exploring this Altmetric report pulling the most discussed articles from the past year.

Most cited

Fitness effects of mutations to SARS-CoV-2 proteins
Jesse D Bloom and Richard A Neher
Virus Evolution, Volume 9, Issue 2, 2023, vead055, https://doi.org/10.1093/ve/vead055
Knowledge of the fitness effects of mutations to SARS-CoV-2 can inform assessment of new variants, design of therapeutics resistant to escape, and understanding of the functions of viral proteins. However, experimentally measuring effects of mutations is challenging: we lack tractable lab assays for many SARS-CoV-2 ...
High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe—Why trends of virus evolution are more difficult to predict
Alice Fusaro and others
Virus Evolution, Volume 10, Issue 1, 2024, veae027, https://doi.org/10.1093/ve/veae027
Since 2016, A(H5Nx) high pathogenic avian influenza (HPAI) virus of clade 2.3.4.4b has become one of the most serious global threats not only to wild and domestic birds, but also to public health. In recent years, important changes in the ecology, epidemiology, and evolution of this virus have been reported, with an ...
Evolution of anelloviruses from a circovirus-like ancestor through gradual augmentation of the jelly-roll capsid protein
Anamarija Butkovic and others
Virus Evolution, Volume 9, Issue 1, 2023, vead035, https://doi.org/10.1093/ve/vead035
Anelloviruses are highly prevalent in diverse mammals, including humans, but so far have not been linked to any disease and are considered to be part of the ‘healthy virome’. These viruses have small circular single-stranded DNA (ssDNA) genomes and encode several proteins with no detectable sequence similarity to proteins ...
Highly pathogenic avian influenza H5N1 virus infections in pinnipeds and seabirds in Uruguay: Implications for bird–mammal transmission in South America
Gonzalo Tomás and others
Virus Evolution, Volume 10, Issue 1, 2024, veae031, https://doi.org/10.1093/ve/veae031
The highly pathogenic avian influenza viruses of clade 2.3.4.4b have caused unprecedented deaths in South American wild birds, poultry, and marine mammals. In September 2023, pinnipeds and seabirds appeared dead on the Uruguayan Atlantic coast. Sixteen influenza virus strains were characterized by real-time reverse ...
A collection of Trichoderma isolates from natural environments in Sardinia reveals a complex virome that includes negative-sense fungal viruses with unprecedented genome organizations
Saul Pagnoni and others
Virus Evolution, Volume 9, Issue 2, 2023, vead042, https://doi.org/10.1093/ve/vead042
Trichoderma genus includes soil-inhabiting fungi that provide important ecosystem services in their interaction with plants and other fungi, as well as biocontrol of fungal plant diseases. A collection of Trichoderma isolates from Sardinia has been previously characterized, but here we selected 113 isolates, ...
Discovery and genome characterization of six new orthoparamyxoviruses in small Belgian mammals
Marie Horemans and others
Virus Evolution, Volume 9, Issue 2, 2023, vead065, https://doi.org/10.1093/ve/vead065
In the future, zoonotic spillover events are expected to occur more frequently. Consequences of such events have clearly been demonstrated by recent outbreaks of monkeypox, Ebola virus, and the well-known severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Virus discovery has proven to be an important tool in the ...
Multiple introductions and country-wide spread of DENV-2 genotype II (Cosmopolitan) in Brazil
Tiago Gräf and others
Virus Evolution, Volume 9, Issue 2, 2023, vead059, https://doi.org/10.1093/ve/vead059
Dengue virus serotype 2, genotype Cosmopolitan (DENV-2-GII), is one of the most widespread DENV strains globally. In the USA, DENV-2 epidemics have been dominated by DENV-2 genotype Asian-American (DENV-2-GIII), and the first cases of DENV-2-GII were only described in 2019, in Peru, and in 2021 in Brazil. To gain new ...
Genomic surveillance and evolutionary dynamics of type 2 porcine reproductive and respiratory syndrome virus in China spanning the African swine fever outbreak
Zhiyong Wu and others
Virus Evolution, Volume 10, Issue 1, 2024, veae016, https://doi.org/10.1093/ve/veae016
Porcine reproductive and respiratory syndrome virus (PRRSV) poses a serious threat to the pig industry in China. Our previous study demonstrated that PRRSV persists with local circulations and overseas imports in China and has formed a relatively stable epidemic pattern. However, the sudden African swine fever (ASF) ...
Origin, genomic diversity and evolution of African swine fever virus in East Asia
Genyang Xin and others
Virus Evolution, Volume 9, Issue 2, 2023, vead060, https://doi.org/10.1093/ve/vead060
Since 2018, the outbreaks of genotype II African swine fever virus (ASFV) in China and several eastern Asian countries have caused a huge impact on the local swine industry, resulting in huge economic losses. However, little is known about the origin, genomic diversity, evolutionary features, and epidemiological history of ...
Newly identified lineages of porcine hemagglutinating encephalomyelitis virus exhibit respiratory phenotype
Wan-Ting He and others
Virus Evolution, Volume 9, Issue 2, 2023, vead051, https://doi.org/10.1093/ve/vead051
Swine pathogens have a long history of zoonotic transmission to humans, occasionally leading to sustained outbreaks or pandemics. Through a retrospective epidemiological study of swine populations in China, we describe novel lineages of porcine hemagglutinating encephalomyelitis virus (PHEV) complex coronaviruses (CoVs) ...

Most read

Research Article
FluMut: a tool for mutation surveillance in highly pathogenic H5N1 genomes
Edoardo Giussani and others
Virus Evolution, Volume 11, Issue 1, 2025, veaf011, https://doi.org/10.1093/ve/veaf011
Over the past century, Influenza A virus (IAV) has caused four of the five reported pandemics, all of which originated from viruses possessing genome segments of avian origin. The recent spread of highly pathogenic avian influenza (HPAI) viruses, particularly the clade 2.3.4.4b A(H5N1) subtype, has led to an alarming ...
Research Article
High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe—Why trends of virus evolution are more difficult to predict
Alice Fusaro and others
Virus Evolution, Volume 10, Issue 1, 2024, veae027, https://doi.org/10.1093/ve/veae027
Since 2016, A(H5Nx) high pathogenic avian influenza (HPAI) virus of clade 2.3.4.4b has become one of the most serious global threats not only to wild and domestic birds, but also to public health. In recent years, important changes in the ecology, epidemiology, and evolution of this virus have been reported, with an ...
Research Article
Genomic variants and molecular epidemiological characteristics of dengue virus in China revealed by genome-wide analysis
Bangyao Sun and others
Virus Evolution, Volume 11, Issue 1, 2025, veaf013, https://doi.org/10.1093/ve/veaf013
Since its first academic record in 1978, dengue epidemics have occurred in all provinces of China, except Xizang. The epidemiological and molecular features of the whole genome of dengue virus (DENV) have not yet been completely elucidated, interfering with prevention and control strategies for dengue fever in China. Here, ...
Research Article
Recently reported SARS-CoV-2 genomes suggested to be intermediate between the two early main lineages are instead likely derived
Jonathan E Pekar and others
Virus Evolution, Volume 11, Issue 1, 2025, veaf008, https://doi.org/10.1093/ve/veaf008
Understanding the genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the outset of the coronavirus disease 2019 pandemic can provide insight into the circumstances leading to its emergence. Early SARS-CoV-2 genomic diversity has been classified into two distinct viral lineages, denoted “A” ...
Research Article
Improvements in RNA and DNA nanopore sequencing allow for rapid genetic characterization of avian influenza
Albert Perlas and others
Virus Evolution, Volume 11, Issue 1, 2025, veaf010, https://doi.org/10.1093/ve/veaf010
Avian influenza virus (AIV) currently causes a panzootic with extensive mortality in wild birds, poultry, and wild mammals, thus posing a major threat to global health and underscoring the need for efficient monitoring of its distribution and evolution. We here utilized a well-defined AIV strain to systematically ...
Research Article
Sequence analysis of the hepatitis D virus across genotypes reveals highly conserved regions amidst evidence of recombination
Shruti Chowdhury and others
Virus Evolution, Volume 11, Issue 1, 2025, veaf012, https://doi.org/10.1093/ve/veaf012
Sequence diversity of the hepatitis D virus (HDV) may impact viral clearance, contributing to the development of chronic infection. T-Cell-induced selection pressure and viral recombination can induce diversity throughout the viral genome including coding and noncoding regions, with the former potentially impacting viral ...
Research Article
Evolutionary trajectory of diverse SARS-CoV-2 variants at the beginning of COVID-19 outbreak
Jia-Xin Lv and others
Virus Evolution, Volume 10, Issue 1, 2024, veae020, https://doi.org/10.1093/ve/veae020
Despite extensive scientific efforts directed toward the evolutionary trajectory of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans at the beginning of the COVID-19 epidemic, it remains unclear how the virus jumped into and evolved in humans so far. Herein, we recruited almost all adult coronavirus ...
Research Article
Geographic origin and evolution of dengue virus serotypes 1 and 3 circulating in Africa
Sindiso Nyathi and others
Virus Evolution, Volume 11, Issue 1, 2025, veae116, https://doi.org/10.1093/ve/veae116
Despite the increasing burden of dengue in Kenya and Africa, the introduction and expansion of the virus in the region remain poorly understood. The objective of this study is to examine the genetic diversity and evolutionary histories of dengue virus (DENV) serotypes 1 and 3 in Kenya and contextualize their circulation ...
Research Article
Fitness effects of mutations to SARS-CoV-2 proteins
Jesse D Bloom and Richard A Neher
Virus Evolution, Volume 9, Issue 2, 2023, vead055, https://doi.org/10.1093/ve/vead055
Knowledge of the fitness effects of mutations to SARS-CoV-2 can inform assessment of new variants, design of therapeutics resistant to escape, and understanding of the functions of viral proteins. However, experimentally measuring effects of mutations is challenging: we lack tractable lab assays for many SARS-CoV-2 ...
Research Article
Evolutionary dynamics and molecular epidemiology of H1N1 pandemic 2009 influenza A viruses across swine farms in Denmark
Sophie George and others
Virus Evolution, Volume 11, Issue 1, 2025, veaf014, https://doi.org/10.1093/ve/veaf014
Transmission of influenza A viruses (IAVs) between pigs and humans can trigger pandemics but more often cease as isolated infections without further spread in the new host species population. In Denmark, a major pig-producing country, the first two detections of human infections with swine-like IAVs were reported in 2021. ...
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