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W. Supanaranond, Y. Suputtamongkol, T.M.E. Davis, S. Pukrittayakamee, P. Teja-Isavadharm, H.K. Webster, N.J. White, Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria, Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 91, Issue 6, November-December 1997, Pages 694–696, https://doi.org/10.1016/S0035-9203(97)90528-9
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Abstract
Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QTc interval was prolonged by a mean of 12% (SD = 8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds.
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