Skip to results
Modify your search
NARROW
1-20 of 20
Authors: Frank D Sistare
Journal Article
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies
Toxicological Sciences, Volume 188, Issue 1, July 2022, Pages 4–16, https://doi.org/10.1093/toxsci/kfac041
Published: 11 April 2022
Journal Article
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin
Toxicological Sciences, Volume 187, Issue 2, June 2022, Pages 219–233, https://doi.org/10.1093/toxsci/kfac030
Published: 14 March 2022
Journal Article
FEATURED
Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats
Toxicological Sciences, Volume 181, Issue 2, June 2021, Pages 148–159, https://doi.org/10.1093/toxsci/kfab038
Published: 09 April 2021
Journal Article
Mechanistic Investigations Support Liver Safety of Ubrogepant
Toxicological Sciences, Volume 177, Issue 1, September 2020, Pages 84–93, https://doi.org/10.1093/toxsci/kfaa093
Published: 24 June 2020
Journal Article
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline
Toxicological Sciences, Volume 177, Issue 1, September 2020, Pages 121–139, https://doi.org/10.1093/toxsci/kfaa094
Published: 19 June 2020
Journal Article
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury
Toxicological Sciences, Volume 177, Issue 1, September 2020, Pages 281–299, https://doi.org/10.1093/toxsci/kfaa088
Published: 19 June 2020
Journal Article
Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities Get access
Toxicological Sciences, Volume 175, Issue 1, May 2020, Pages 98–112, https://doi.org/10.1093/toxsci/kfaa026
Published: 02 March 2020
Journal Article
Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3 Get access
Toxicological Sciences, Volume 172, Issue 1, November 2019, Pages 155–166, https://doi.org/10.1093/toxsci/kfz186
Published: 12 August 2019
Journal Article
AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats Get access
Toxicological Sciences, Volume 171, Issue 1, September 2019, Pages 46–55, https://doi.org/10.1093/toxsci/kfz125
Published: 25 May 2019
Journal Article
Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity Get access
Toxicological Sciences, Volume 170, Issue 1, July 2019, Pages 180–198, https://doi.org/10.1093/toxsci/kfz079
Published: 23 March 2019
Journal Article
A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury Get access
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 110–125, https://doi.org/10.1093/toxsci/kfy282
Published: 28 November 2018
Journal Article
Response of Novel Skeletal Muscle Biomarkers in Dogs to Drug-Induced Skeletal Muscle Injury or Sustained Endurance Exercise Get access
Toxicological Sciences, Volume 156, Issue 2, April 2017, Pages 422–427, https://doi.org/10.1093/toxsci/kfw262
Published: 23 January 2017
Journal Article
Antibiotic-Induced Elevations of Plasma Bile Acids in Rats Independent of Bsep Inhibition Get access
Toxicological Sciences, Volume 157, Issue 1, May 2017, Pages 30–40, https://doi.org/10.1093/toxsci/kfx015
Published: 20 January 2017
Journal Article
Evaluation of the Relative Performance of 12 Urinary Biomarkers for Renal Safety Across 22 Rat Sensitivity and Specificity Studies Get access
Toxicological Sciences, Volume 138, Issue 1, March 2014, Pages 3–20, https://doi.org/10.1093/toxsci/kft330
Published: 21 December 2013
Journal Article
EDITOR'S CHOICE
A Performance Evaluation of Three Drug-Induced Liver Injury Biomarkers in the Rat: Alpha-Glutathione S-Transferase, Arginase 1, and 4-Hydroxyphenyl-Pyruvate Dioxygenase Get access
Toxicological Sciences, Volume 130, Issue 2, December 2012, Pages 229–244, https://doi.org/10.1093/toxsci/kfs243
Published: 07 August 2012
Journal Article
The Utility of Genetically Modified Mouse Assays for Identifying Human Carcinogens: A Basic Understanding and Path Forward Get access
Toxicological Sciences, Volume 77, Issue 2, February 2004, Pages 188–194, https://doi.org/10.1093/toxsci/kfh037
Published: 01 February 2004
Journal Article
Evaluation of the Tg.AC Assay: Specificity Testing with Three Noncarcinogenic Pharmaceuticals that Induce Selected Stress Gene Promoters in Vitro and the Inhibitory Effects of Solvent Components Get access
Toxicological Sciences, Volume 74, Issue 2, August 2003, Pages 271–278, https://doi.org/10.1093/toxsci/kfg141
Published: 01 August 2003
Journal Article
Selection of Drugs to Test the Specificity of the Tg.AC Assay by Screening for Induction of the gadd153 Promoter in Vitro Get access
Toxicological Sciences, Volume 74, Issue 2, August 2003, Pages 260–270, https://doi.org/10.1093/toxsci/kfg113
Published: 01 August 2003
Journal Article
Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity Get access
Toxicological Sciences, Volume 68, Issue 1, July 2002, Pages 9–17, https://doi.org/10.1093/toxsci/68.1.9
Published: 01 July 2002
Journal Article
Evaluation of in Vitro Reporter Gene Induction Assays for Use in a Rapid Prescreen for Compound Selection to Test Specificity in the Tg.AC Mouse Short-Term Carcinogenicity Assay Get access
Toxicological Sciences, Volume 57, Issue 1, September 2000, Pages 43–53, https://doi.org/10.1093/toxsci/57.1.43
Published: 01 September 2000
