Volume 127, Issue 1
May 2012
Cover image
Cover image
Cover illustration. This figure from Stansfield et al. (this issue pp. 277-295) demonstrates mechanisms of neurotoxicity that are induced by lead (Pb2+) exposure. The left side shows a normal functioning synapse (green arrows), and the right side demonstrates sites of toxicity induced by lead (red arrows).
ISSN 1096-6080
EISSN 1096-0929
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Volume 127, Issue 1, May 2012
REVIEW
Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 1–9, https://doi.org/10.1093/toxsci/kfs095
FORUM
Incorporating Nonchemical Stressors Into Cumulative Risk Assessments
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 10–17, https://doi.org/10.1093/toxsci/kfs088
BIOMARKERS OF TOXICITY
Ethanol Exposure Induces Upregulation of Specific MicroRNAs in Zebrafish Embryos
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 18–28, https://doi.org/10.1093/toxsci/kfs068
BIOTRANSFORMATION AND TOXICOKINETICS
CYP450-Dependent Biotransformation of the Insecticide Fipronil into Fipronil Sulfone Can Mediate Fipronil-Induced Thyroid Disruption in Rats
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 29–41, https://doi.org/10.1093/toxsci/kfs094
CARCINOGENICITY
Ethanol Disrupts Vascular Endothelial Barrier: Implication in Cancer Metastasis
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 42–53, https://doi.org/10.1093/toxsci/kfs087
The Hepatocarcinogenic Conazoles: Cyproconazole, Epoxiconazole, and Propiconazole Induce a Common Set of Toxicological and Transcriptional Responses
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 54–65, https://doi.org/10.1093/toxsci/kfs086
ENDOCRINE TOXICOLOGY
Cadmium-Induced Effects on Cellular Signaling Pathways in the Liver of Transgenic Estrogen Reporter Mice
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 66–75, https://doi.org/10.1093/toxsci/kfs077
Developmental Coexposure to Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers Has Additive Effects on Circulating Thyroxine Levels in Rats
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 76–83, https://doi.org/10.1093/toxsci/kfs089
ENVIRONMENTAL TOXICOLOGY
Prenatal Carbofuran Exposure Inhibits Hippocampal Neurogenesis and Causes Learning and Memory Deficits in Offspring
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 84–100, https://doi.org/10.1093/toxsci/kfs004
A Novel Aquaporin 3 in Killifish (Fundulus heteroclitus) Is Not An Arsenic Channel
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 101–109, https://doi.org/10.1093/toxsci/kfs078
Differential Inhibition of Electron Transport Chain Enzyme Complexes by Cadmium and Calcium in Isolated Rainbow Trout (Oncorhynchus mykiss) Hepatic Mitochondria
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 110–119, https://doi.org/10.1093/toxsci/kfs091
Poly(ADP-Ribose) Polymerase-1 Inhibition by Arsenite Promotes the Survival of Cells With Unrepaired DNA Lesions Induced by UV Exposure
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 120–129, https://doi.org/10.1093/toxsci/kfs099
GENETIC TOXICOLOGY
Different Sets of Translesion Synthesis DNA Polymerases Protect From Genome Instability Induced by Distinct Food-Derived Genotoxins
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 130–138, https://doi.org/10.1093/toxsci/kfs074
Sodium Arsenite ± Hyperthermia Sensitizes p53-Expressing Human Ovarian Cancer Cells to Cisplatin by Modulating Platinum-DNA Damage Responses
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 139–149, https://doi.org/10.1093/toxsci/kfs085
IMMUNOTOXICOLOGY
The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 150–158, https://doi.org/10.1093/toxsci/kfs080
Editor's Highlight: This paper reports an in vitro cell culture system from human donors for the prediction of the allergic potential of drugs. Naive T cells were cultured in the presence of a drug and tested for transformation of the naive phenotype into a memory phenotype. These results demonstrate a system that can predict possible drug allergy resulting in serious adverse effects in a system that does not utilize experimental animals.
Chronic Administration of Belatacept, a T-cell Costimulatory Signal Blocker, in Cynomolgus Monkeys
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 159–168, https://doi.org/10.1093/toxsci/kfs081
Epigenetic Alterations May Regulate Temporary Reversal of CD4+ T Cell Activation Caused by Trichloroethylene Exposure
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 169–178, https://doi.org/10.1093/toxsci/kfs093
IN VITRO METHODS AND ALTERNATIVES TO ANIMALS
Circulating Factors Induce Coronary Endothelial Cell Activation Following Exposure to Inhaled Diesel Exhaust and Nitrogen Dioxide in Humans: Evidence From a Novel Translational In Vitro Model
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 179–186, https://doi.org/10.1093/toxsci/kfs084
Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 187–198, https://doi.org/10.1093/toxsci/kfs083
MOLECULAR TOXICOLOGY
Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 199–215, https://doi.org/10.1093/toxsci/kfs069
In Ovo Effects of Perfluorohexane Sulfonate and Perfluorohexanoate on Pipping Success, Development, mRNA Expression, and Thyroid Hormone Levels in Chicken Embryos
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 216–224, https://doi.org/10.1093/toxsci/kfs072
The Novel Antibacterial Compound Walrycin A Induces Human PXR Transcriptional Activity
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 225–235, https://doi.org/10.1093/toxsci/kfs073
Fibrodysplasia Induced in Dog Skin by a Matrix Metalloproteinase (MMP) Inhibitor—A Mechanistic Analysis
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 236–245, https://doi.org/10.1093/toxsci/kfs075
Histone Deacetylase 6 Associates With Ribosomes and Regulates De Novo Protein Translation During Arsenite Stress
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 246–255, https://doi.org/10.1093/toxsci/kfs070
NANOTOXICOLOGY
Distribution, Elimination, and Biopersistence to 90 Days of a Systemically Introduced 30 nm Ceria-Engineered Nanomaterial in Rats
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 256–268, https://doi.org/10.1093/toxsci/kfs067
NEUROTOXICOLOGY
Early Exposure to 2,2′,4,4′,5-Pentabromodiphenyl Ether (BDE-99) Affects Mating Behavior of Zebra Finches
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 269–276, https://doi.org/10.1093/toxsci/kfs076
Dysregulation of BDNF-TrkB Signaling in Developing Hippocampal Neurons by Pb2+: Implications for an Environmental Basis of Neurodevelopmental Disorders
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 277–295, https://doi.org/10.1093/toxsci/kfs090
REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
Gestational Exposure to BDE-99 Produces Toxicity Through Upregulation of CYP Isoforms and ROS Production in the Fetal Rat Liver
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 296–302, https://doi.org/10.1093/toxsci/kfs082
Concentration-Response Analysis of Differential Gene Expression in the Zebrafish Embryotoxicity Test Following Flusilazole Exposure
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 303–312, https://doi.org/10.1093/toxsci/kfs092
LETTER TO EDITOR
What It Means to Be Global
Toxicological Sciences, Volume 127, Issue 1, May 2012, Pages 313–314, https://doi.org/10.1093/toxsci/kfs079
COVER
COVER
Toxicological Sciences, Volume 127, Issue 1, May 2012, Page NP, https://doi.org/10.1093/toxsci/kfs145
STANDING MATERIAL
EDITORIAL BOARD
Toxicological Sciences, Volume 127, Issue 1, May 2012, Page NP, https://doi.org/10.1093/toxsci/kfs037
SUBSCRIPTIONS
Toxicological Sciences, Volume 127, Issue 1, May 2012, Page NP, https://doi.org/10.1093/toxsci/kfs038
TABLE OF CONTENTS
Toxicological Sciences, Volume 127, Issue 1, May 2012, Page NP, https://doi.org/10.1093/toxsci/kfs039
