Volume 126, Issue 2, April 2012

Forum

Identification and Characterization of Adverse Effects in 21^st Century Toxicology

Douglas A. Keller and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 291–297, https://doi.org/10.1093/toxsci/kfr350

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BIOMARKERS OF TOXICITY

Antifungal Miconazole Induces Cardiotoxicity Via Inhibition of APE/Ref-1-Related Pathway in Rat Neonatal Cardiomyocytes

Kyung-Jong Won and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 298–305, https://doi.org/10.1093/toxsci/kfr347

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Editor's Choice

Metabolic Profiling of the Rat Liver After Chronic Ingestion of Alpha-Naphthylisothiocyanate Using In Vivo and Ex Vivo Magnetic Resonance Spectroscopy

Bhavana S. Solanky and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 306–316, https://doi.org/10.1093/toxsci/kfs019

Editor's Highlight: This study demonstrated that hepatobiliary toxicity could be characterized in a living animal noninvasively by ³¹P magnetic resonance spectroscopy. These results demonstrate the feasibility of following toxicity biomarkers longitudinally in the same animal, resulting in better studies that can associate biomarkers with various liver injury patterns while reducing the number of animals needed in toxicology studies.

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BIOTRANSFORMATION AND TOXICOKINETICS

Pharmacokinetics of Melamine and Cyanuric Acid and Their Combinations in F344 Rats

Cristina C. Jacob and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 317–324, https://doi.org/10.1093/toxsci/kfr348

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Rat Brain CYP2B-Enzymatic Activation of Chlorpyrifos to the Oxon Mediates Cholinergic Neurotoxicity

Jibran Y. Khokhar and Rachel F. Tyndale

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 325–335, https://doi.org/10.1093/toxsci/kfs029

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CARCINOGENICITY

Identification and Pathway Mapping of Furan Target Proteins Reveal Mitochondrial Energy Production and Redox Regulation as Critical Targets of Furan Toxicity

Sabrina Moro and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 336–352, https://doi.org/10.1093/toxsci/kfs005

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ENDOCRINE TOXICOLOGY

The Anabolic Androgenic Steroid Fluoxymesterone Inhibits 11β-Hydroxysteroid Dehydrogenase 2–Dependent Glucocorticoid Inactivation

Cornelia Fürstenberger and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 353–361, https://doi.org/10.1093/toxsci/kfs022

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ENVIRONMENTAL TOXICOLOGY

Proinflammatory Adhesion Molecules Facilitate Polychlorinated Biphenyl–Mediated Enhancement of Brain Metastasis Formation

Eszter Sipos and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 362–371, https://doi.org/10.1093/toxsci/kfr349

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GENETIC TOXICOLOGY

Mechanism of Inhibition of the ATPase Domain of Human Topoisomerase IIα by 1,4-Benzoquinone, 1,2-Naphthoquinone, 1,4-Naphthoquinone, and 9,10-Phenanthroquinone

Deepak Gurbani and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 372–390, https://doi.org/10.1093/toxsci/kfr345

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Inherent and Benzo[a]pyrene-Induced Differential Aryl Hydrocarbon Receptor Signaling Greatly Affects Life Span, Atherosclerosis, Cardiac Gene Expression, and Body and Heart Growth in Mice

Joanna S. Kerley-Hamilton and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 391–404, https://doi.org/10.1093/toxsci/kfs002

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Dose-Response Assessment of Naphthalene-Induced Genotoxicity and Glutathione Detoxication in Human TK6 Lymphoblasts

Leslie Recio and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 405–412, https://doi.org/10.1093/toxsci/kfs012

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IMMUNOTOXICOLOGY

Differential Gene Expression Responses Distinguish Contact and Respiratory Sensitizers and Nonsensitizing Irritants in the Local Lymph Node Assay

David Adenuga and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 413–425, https://doi.org/10.1093/toxsci/kfs071

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IN VITRO METHODS AND ALTERNATIVES TO ANIMALS

Novel Application of Human Neurons Derived from Induced Pluripotent Stem Cells for Highly Sensitive Botulinum Neurotoxin Detection

Regina C. M. Whitemarsh and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 426–435, https://doi.org/10.1093/toxsci/kfr354

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Intracellular Pb²⁺ Content Monitoring Using a Protein-Based Pb²⁺ Indicator

Tai-Yu Chiu and De-Ming Yang

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 436–445, https://doi.org/10.1093/toxsci/kfs007

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MOLECULAR TOXICOLOGY

Antibody-Mediated Inhibition of Fibroblast Growth Factor 19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys

Rama Pai and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 446–456, https://doi.org/10.1093/toxsci/kfs011

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NANOTOXICOLOGY

Effects of Silver Nanoparticles on Primary Mixed Neural Cell Cultures: Uptake, Oxidative Stress and Acute Calcium Responses

Andrea Haase and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 457–468, https://doi.org/10.1093/toxsci/kfs003

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Zeta Potential and Solubility to Toxic Ions as Mechanisms of Lung Inflammation Caused by Metal/Metal Oxide Nanoparticles

Wan-Seob Cho and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 469–477, https://doi.org/10.1093/toxsci/kfs006

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Cadmium Associated With Inhaled Cadmium Oxide Nanoparticles Impacts Fetal and Neonatal Development and Growth

Jason L. Blum and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 478–486, https://doi.org/10.1093/toxsci/kfs008

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NEUROTOXICOLOGY

Differential Effects of 20 Non–Dioxin-Like PCBs on Basal and Depolarization-Evoked Intracellular Calcium Levels in PC12 Cells

Wendy T. Langeveld and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 487–496, https://doi.org/10.1093/toxsci/kfr346

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Repeated Exposure to Sublethal Doses of the Organophosphorus Compound VX Activates BDNF Expression in Mouse Brain

Jose M. Pizarro and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 497–505, https://doi.org/10.1093/toxsci/kfr353

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Differing Effects of Toxicants (Methylmercury, Inorganic Mercury, Lead, Amyloid β, and Rotenone) on Cultured Rat Cerebrocortical Neurons: Differential Expression of Rho Proteins Associated With Neurotoxicity

Masatake Fujimura and Fusako Usuki

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 506–514, https://doi.org/10.1093/toxsci/kfr352

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Efficacy Assessment of Various Anticholinergic Agents Against Topical Sarin-Induced Miosis and Visual Impairment in Rats

Ariel Gore and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 515–524, https://doi.org/10.1093/toxsci/kfs009

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Synthesis and In Vitro and In Vivo Inhibition Potencies of Highly Relevant Nerve Agent Surrogates

Edward C. Meek and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 525–533, https://doi.org/10.1093/toxsci/kfs013

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Functional Rehabilitation of Cadmium-Induced Neurotoxicity Despite Persistent Peripheral Pathophysiology in the Olfactory System

Lindsey A. Czarnecki and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 534–544, https://doi.org/10.1093/toxsci/kfs030

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REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Differences in Radiation Sensitivity of Recovery of Spermatogenesis Between Rat Strains

Mahmoud Abuelhija and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 545–553, https://doi.org/10.1093/toxsci/kfs021

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RESPIRATORY TOXICOLOGY

Aryl Hydrocarbon Receptor (AhR) Regulates Silica-Induced Inflammation But Not Fibrosis

Celine A. Beamer and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 554–568, https://doi.org/10.1093/toxsci/kfs024

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SYSTEMS TOXICOLOGY

DNA Double-Strand Breaks and DNA Recombination in Benzene Metabolite–Induced Genotoxicity

Emily W. Y. Tung and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 569–577, https://doi.org/10.1093/toxsci/kfs001

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Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model

Eric F. Lock and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 578–588, https://doi.org/10.1093/toxsci/kfs023

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TRANSLATIONAL RESEARCH IN TOXICOLOGY

Protein Phosphatase 2A Regulates Innate Immune and Proteolytic Responses to Cigarette Smoke Exposure in the Lung

Alison M. Wallace and others

Toxicological Sciences, Volume 126, Issue 2, April 2012, Pages 589–599, https://doi.org/10.1093/toxsci/kfr351

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Standing Materials

EDITORIAL BOARD

Toxicological Sciences, Volume 126, Issue 2, April 2012, Page NP, https://doi.org/10.1093/toxsci/kfs034

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SUBSCRIPTIONS

Toxicological Sciences, Volume 126, Issue 2, April 2012, Page NP, https://doi.org/10.1093/toxsci/kfs035

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TABLE OF CONTENTS

Toxicological Sciences, Volume 126, Issue 2, April 2012, Page NP, https://doi.org/10.1093/toxsci/kfs036

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COVER

COVER

Toxicological Sciences, Volume 126, Issue 2, April 2012, Page NP, https://doi.org/10.1093/toxsci/kfs116

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