Volume 118, Issue 2, December 2010

TOXICOLOGICAL HIGHLIGHT

Metabolomics and Mechanisms: Sometimes the Fisher Catches a Big Fish

Glenn H. Cantor

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 321–323, https://doi.org/10.1093/toxsci/kfq297

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Review

Nephrotoxicity of Uranium: Pathophysiological, Diagnostic and Therapeutic Perspectives

Laura Vicente-Vicente and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 324–347, https://doi.org/10.1093/toxsci/kfq178

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Forum

Safety of Vitamins and Minerals: Controversies and Perspective

Madhu G. Soni and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 348–355, https://doi.org/10.1093/toxsci/kfq293

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ICH Guidelines: Inception, Revision, and Implications for Drug Development

Tao Wang and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 356–367, https://doi.org/10.1093/toxsci/kfq286

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BIOTRANSFORMATION AND TOXICOKINETICS

Exposure to Hexavalent Chromium Resulted in Significantly Higher Tissue Chromium Burden Compared With Trivalent Chromium Following Similar Oral Doses to Male F344/N Rats and Female B6C3F1 Mice

Bradley J. Collins and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 368–379, https://doi.org/10.1093/toxsci/kfq263

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Alterations in Hepatic mRNA Expression of Phase II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 Alpha

Hong Lu and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 380–390, https://doi.org/10.1093/toxsci/kfq280

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Functional Genetic Variants in the 3′-Untranslated Region of Sulfotransferase Isoform 1A1 (SULT1A1) and Their Effect on Enzymatic Activity

Xinfeng Yu and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 391–403, https://doi.org/10.1093/toxsci/kfq296

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CARCINOGENICITY

PPARα-Dependent Activation of Cell Cycle Control and DNA Repair Genes in Hepatic Nonparenchymal Cells

Aijuan Qu and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 404–410, https://doi.org/10.1093/toxsci/kfq259

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ENDOCRINE TOXICOLOGY

Effects and Mechanisms of Nonylphenol on Corticosterone Release in Rat Zona Fasciculata-Reticularis Cells

Ling-Ling Chang and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 411–419, https://doi.org/10.1093/toxsci/kfq274

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ENVIRONMENTAL TOXICOLOGY

Effect of Size Fractionation on the Toxicity of Amosite and Libby Amphibole Asbestos

Kelly E. Duncan and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 420–434, https://doi.org/10.1093/toxsci/kfq281

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GENETIC TOXICOLOGY

Emodin Triggers DNA Double-Strand Breaks by Stabilizing Topoisomerase II-DNA Cleavage Complexes and by Inhibiting ATP Hydrolysis of Topoisomerase II

Yan Li and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 435–443, https://doi.org/10.1093/toxsci/kfq282

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Caenorhabditis elegans Generates Biologically Relevant Levels of Genotoxic Metabolites from Aflatoxin B₁ but Not Benzo[a]pyrene In Vivo

Maxwell C. K. Leung and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 444–453, https://doi.org/10.1093/toxsci/kfq295

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IMMUNOTOXICOLOGY

An Integrated Genomic Analysis of Aryl Hydrocarbon Receptor-Mediated Inhibition of B-Cell Differentiation

K. Nadira De Abrew and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 454–469, https://doi.org/10.1093/toxsci/kfq265

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IN VITRO METHODS AND ALTERNATIVES TO ANIMALS

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man

Jochem Louisse and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 470–484, https://doi.org/10.1093/toxsci/kfq270

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Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

Ryan E. Morgan and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 485–500, https://doi.org/10.1093/toxsci/kfq269

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Role of Oxidative Metabolism in the Effect of Valproic Acid on Markers of Cell Viability, Necrosis, and Oxidative Stress in Sandwich-Cultured Rat Hepatocytes

Tony K. L. Kiang and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 501–509, https://doi.org/10.1093/toxsci/kfq294

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MOLECULAR TOXICOLOGY

Effects of 2-Bromoethanamine on TonEBP Expression and Its Possible Role in Induction of Renal Papillary Necrosis in Mice

Ana Andres-Hernando and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 510–520, https://doi.org/10.1093/toxsci/kfq261

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Effect of N-Acetyl Cysteine and α-Linolenic Acid on Sulfur Mustard Caused Impairment of In Vitro Endothelial Tube Formation

Dirk Steinritz and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 521–529, https://doi.org/10.1093/toxsci/kfq271

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The Glutaredoxin GLRX-21 Functions to Prevent Selenium-Induced Oxidative Stress in Caenorhabditis elegans

Kathleen L. Morgan and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 530–543, https://doi.org/10.1093/toxsci/kfq273

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Benzo[a]pyrene Inhibits Angiogenic Factors–Induced αvβ3 Integrin Expression, Neovasculogenesis, and Angiogenesis in Human Umbilical Vein Endothelial Cells

Ching-Hao Li and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 544–553, https://doi.org/10.1093/toxsci/kfq279

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Aryl Hydrocarbon Receptor Nuclear Translocator in Hepatocytes Is Required for Aryl Hydrocarbon Receptor–Mediated Adaptive and Toxic Responses in Liver

Manabu Nukaya and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 554–563, https://doi.org/10.1093/toxsci/kfq305

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NANOTOXICOLOGY

Clearance Kinetics of Fullerene C₆₀ Nanoparticles from Rat Lungs after Intratracheal C₆₀ Instillation and Inhalation C₆₀ Exposure

Naohide Shinohara and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 564–573, https://doi.org/10.1093/toxsci/kfq288

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Oxidative Stress, Inflammation, and DNA Damage in Rats after Intratracheal Instillation or Oral Exposure to Ambient Air and Wood Smoke Particulate Matter

Pernille Høgh Danielsen and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 574–585, https://doi.org/10.1093/toxsci/kfq290

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NEUROTOXICOLOGY

Characterization of Developmental Neurotoxicity of As, Cd, and Pb Mixture: Synergistic Action of Metal Mixture in Glial and Neuronal Functions

Asit Rai and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 586–601, https://doi.org/10.1093/toxsci/kfq266

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Chronic Ethanol Exposure Alters the Levels, Assembly, and Cellular Organization of the Actin Cytoskeleton and Microtubules in Hippocampal Neurons in Primary Culture

Ana M. Romero and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 602–612, https://doi.org/10.1093/toxsci/kfq260

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SKN-1/Nrf2 Inhibits Dopamine Neuron Degeneration in a Caenorhabditis elegans Model of Methylmercury Toxicity

Natalia VanDuyn and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 613–624, https://doi.org/10.1093/toxsci/kfq285

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Prenatal Polycyclic Aromatic Hydrocarbon Exposure Leads to Behavioral Deficits and Downregulation of Receptor Tyrosine Kinase, MET

Liu Sheng and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 625–634, https://doi.org/10.1093/toxsci/kfq304

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PCB-47, PBDE-47, and 6-OH-PBDE-47 Differentially Modulate Human GABA_A and α₄β₂ Nicotinic Acetylcholine Receptors

Hester S. Hendriks and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 635–642, https://doi.org/10.1093/toxsci/kfq284

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REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

HIGHLIGHTED ARTICLE:

Ethylene Glycol Monomethyl Ether–Induced Toxicity Is Mediated through the Inhibition of Flavoprotein Dehydrogenase Enzyme Family

Makoto Takei and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 643–652, https://doi.org/10.1093/toxsci/kfq211

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Adding Insult to Injury: Effects of Xenobiotic-Induced Preantral Ovotoxicity on Ovarian Development and Oocyte Fusibility

Alexander P. Sobinoff and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 653–666, https://doi.org/10.1093/toxsci/kfq272

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Stimulatory Effects of Propylthiouracil on Pregnenolone Production through Upregulation of Steroidogenic Acute Regulatory Protein Expression in Rat Granulosa Cells

Mei-Chih Chen and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 667–674, https://doi.org/10.1093/toxsci/kfq302

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Embryotoxicant-Specific Transcriptomic Responses in Rat Postimplantation Whole-Embryo Culture

Joshua F. Robinson and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 675–685, https://doi.org/10.1093/toxsci/kfq292

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Teratogen-Induced Oxidative Stress Targets Glyceraldehyde-3-Phosphate Dehydrogenase in the Organogenesis Stage Mouse Embryo

Ava E. Schlisser and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 686–695, https://doi.org/10.1093/toxsci/kfq287

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RESPIRATORY TOXICOLOGY

Deviations from Haber’s Law for Multiple Measures of Acute Lung Injury in Chlorine-Exposed Mice

Gary W. Hoyle and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 696–703, https://doi.org/10.1093/toxsci/kfq264

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Risk assessment

Analysis of the CYP1A1 mRNA Dose-Response in Human Keratinocytes Indicates that Relative Potencies of Dioxins, Furans, and PCBs Are Species and Congener Specific

Carrie H. Sutter and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 704–715, https://doi.org/10.1093/toxsci/kfq262

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SYSTEMS TOXICOLOGY

Formaldehyde: Integrating Dosimetry, Cytotoxicity, and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound

Melvin E. Andersen and others

Toxicological Sciences, Volume 118, Issue 2, December 2010, Pages 716–731, https://doi.org/10.1093/toxsci/kfq303

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Erratum

Erratum

Toxicological Sciences, Volume 118, Issue 2, December 2010, Page 732, https://doi.org/10.1093/toxsci/kfq321

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COVER

Cover

Toxicological Sciences, Volume 118, Issue 2, December 2010, Page NP, https://doi.org/10.1093/toxsci/kfq350

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Standing Materials

Editorial Board

Toxicological Sciences, Volume 118, Issue 2, December 2010, Page NP, https://doi.org/10.1093/toxsci/kfq351

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Subscriptions

Toxicological Sciences, Volume 118, Issue 2, December 2010, Page NP, https://doi.org/10.1093/toxsci/kfq352

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Contents

Toxicological Sciences, Volume 118, Issue 2, December 2010, Page NP, https://doi.org/10.1093/toxsci/kfq353

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