Volume 108, Issue 2, April 2009

TOXICOLOGICAL HIGHLIGHT

Safety Evaluation of Silver Nanoparticles: Inhalation Model for Chronic Exposure

Saber M. Hussain and John J. Schlager

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 223–224, https://doi.org/10.1093/toxsci/kfp032

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Review

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification

Yazen Alnouti

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 225–246, https://doi.org/10.1093/toxsci/kfn268

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BIOTRANSFORMATION AND TOXICOKINETICS

ANIT-Induced Intrahepatic Cholestasis Alters Hepatobiliary Transporter Expression via Nrf2-Dependent and Independent Signaling

Yuji Tanaka and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 247–257, https://doi.org/10.1093/toxsci/kfp020

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The Effect of Plasma Lipids on the Pharmacokinetics of Chlorpyrifos and the Impact on Interpretation of Blood Biomonitoring Data

Ezra R. Lowe and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 258–272, https://doi.org/10.1093/toxsci/kfp034

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CARCINOGENICITY

Multiple Genes Exhibit Phenobarbital-Induced Constitutive Active/Androstane Receptor–Mediated DNA Methylation Changes during Liver Tumorigenesis and in Liver Tumors

Jennifer M. Phillips and Jay I. Goodman

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 273–289, https://doi.org/10.1093/toxsci/kfp031

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Molecular Signatures of N-nitroso Compounds in Caco-2 Cells: Implications for Colon Carcinogenesis

Dennie G. A. J. Hebels and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 290–300, https://doi.org/10.1093/toxsci/kfp035

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ENDOCRINE TOXICOLOGY

Hexachlorobenzene Triggers Apoptosis in Rat Thyroid Follicular Cells

Florencia Chiappini and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 301–310, https://doi.org/10.1093/toxsci/kfp016

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Developmental Exposure to Chlorpyrifos Induces Alterations in Thyroid and Thyroid Hormone Levels Without Other Toxicity Signs in Cd1 Mice

Simona De Angelis and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 311–319, https://doi.org/10.1093/toxsci/kfp017

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ENVIRONMENTAL TOXICOLOGY

Influence of Dietary Coexposure to Benzo(a)pyrene on the Biotransformation and Distribution of ¹⁴C-Methoxychlor in the Channel Catfish (Ictalurus punctatus)

Beatrice A. Nyagode and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 320–329, https://doi.org/10.1093/toxsci/kfp018

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Dioxin-Sensitive Proteins in Differentiating Osteoblasts: Effects on Bone Formation In Vitro

Donatella Carpi and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 330–343, https://doi.org/10.1093/toxsci/kfp021

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Bisphenol A Disrupts Notch Signaling by Inhibiting Gamma-Secretase Activity and Causes Eye Dysplasia of Xenopus laevis

Kazunobu Baba and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 344–355, https://doi.org/10.1093/toxsci/kfp025

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IMMUNOTOXICOLOGY

N-Acetyl Cysteine Mediates Protection from 2-Hydroxyethyl Methacrylate Induced Apoptosis via Nuclear Factor Kappa B–Dependent and Independent Pathways: Potential Involvement of JNK

Avina Paranjpe and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 356–366, https://doi.org/10.1093/toxsci/kfp010

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Alterations of Cytokines and MAPK Signaling Pathways are Related to the Immunotoxic Effect of Perfluorononanoic Acid

Xuemei Fang and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 367–376, https://doi.org/10.1093/toxsci/kfp019

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Involvement of Blimp-1 and AP-1 Dysregulation in the 2,3,7,8-Tetrachlorodibenzo-p-dioxin–mediated Suppression of the IgM Response by B Cells

Dina Schneider and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 377–388, https://doi.org/10.1093/toxsci/kfp028

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IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Embryonic Stem Cell Test Remastered: Comparison between the Validated EST and the New Molecular FACS-EST for Assessing Developmental Toxicity In Vitro

Roland Buesen and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 389–400, https://doi.org/10.1093/toxsci/kfp012

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Reactivity Profiling: Covalent Modification of Single Nucleophile Peptides for Skin Sensitization Risk Assessment

Maja Aleksic and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 401–411, https://doi.org/10.1093/toxsci/kfp030

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NEUROTOXICOLOGY

Neonatal Exposure to PFOS and PFOA in Mice Results in Changes in Proteins which are Important for Neuronal Growth and Synaptogenesis in the Developing Brain

Niclas Johansson and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 412–418, https://doi.org/10.1093/toxsci/kfp029

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REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Inhibiting the Teratogenicity of the Immunosuppressant Leflunomide in Mice by Supplementation of Exogenous Uridine

Ryou Fukushima and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 419–426, https://doi.org/10.1093/toxsci/kfp022

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Bisphenol A Exposure Induces Apoptosis and Upregulation of Fas/FasL and Caspase-3 Expression in the Testes of Mice

Yuan-Jie Li and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 427–436, https://doi.org/10.1093/toxsci/kfp024

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Evaluation of Endocrine Disrupting Effects of Nitrate after In Utero Exposure in Rats and of Nitrate and Nitrite in the H295R and T-Screen Assay

Pernille Reimer Hansen and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 437–444, https://doi.org/10.1093/toxsci/kfp023

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Proapoptotic Effects of Lindane on Mouse Primordial Germ Cells

Gina La Sala and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 445–451, https://doi.org/10.1093/toxsci/kfp027

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RESPIRATORY TOXICOLOGY

Highlighted Article

Subchronic Inhalation Toxicity of Silver Nanoparticles

Jae Hyuck Sung and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 452–461, https://doi.org/10.1093/toxsci/kfn246

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Critical Role of MARCO in Crystalline Silica–Induced Pulmonary Inflammation

Sheetal A. Thakur and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 462–471, https://doi.org/10.1093/toxsci/kfp011

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Sintered Indium-Tin-Oxide (ITO) Particles: A New Pneumotoxic Entity

Dominique Lison and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 472–481, https://doi.org/10.1093/toxsci/kfp014

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SYSTEMS TOXICOLOGY

Hepatobiliary Disposition of Thyroid Hormone in Mrp2-Deficient TR⁻ Rats: Reduced Biliary Excretion of Thyroxine Glucuronide Does Not Prevent Xenobiotic-Induced Hypothyroidism

Lloyd Lecureux and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 482–491, https://doi.org/10.1093/toxsci/kfp026

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Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714

Bo Feng and others

Toxicological Sciences, Volume 108, Issue 2, April 2009, Pages 492–500, https://doi.org/10.1093/toxsci/kfp033

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Erratum

Erratum

Toxicological Sciences, Volume 108, Issue 2, April 2009, Page 501, https://doi.org/10.1093/toxsci/kfp042

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