... via the Permissions link on the article page on our site—for further information please contact [email protected]. lipopolysaccharide toll-like receptors cytokine mouse Abstract Background Lipopolysaccharide (LPS), a constituent of the Gram-negative bacterial cell wall, activates Toll...

... and in vivo. Methods Venous blood and self-reported health data were collected from 56 and 73 Norwegian drilling waste workers, respectively. Immunological effects were assessed as Toll-like receptor (TLR) activation potential of personal air samples in vitro and biomarker expression in workers’ plasma...

... Abstract toll-like receptors pathogen-associated molecular patterns monocytes neonates cytokines Department of Biotechnology, Ministry of Science and Technology, India (DBT) BT/PR30219/MED/15/189/2018 DBT-National Institutes of Health (NIH) DBT-Biotechnology Industry Research Assistance...

... TLR ligand. diabetes hyperglycemia immunometabolism innate immunity macrophages monocytes toll-like receptors Hyperglycemia (HG) is a key factor in diabetes pathology as it provides the biochemical environment for detrimental inflammatory responses that consequently lead to the development...

... and medical subject headings related to the following terms: “erectile dysfunction”, “international index of erectile function”, “Peyronie’s disease”, “obesity”, “diabetes mellitus” “macrophages”, “phosphodiesterase type 5 inhibitors”, “polyphenols”, “stem cells”, “toll-like receptors”, “interleukin...

... for the development of immune paralysis. In our cohort, pDCs were identified as the most robust subset to predict 30-d mortality. Plasmacytoid dendritic cells predict survival at the intensive care unit. critical care dendritic cells plasmacytoid dendritic cells SIRS Toll-like receptors Association...

... to HC. (D) No significant differences in TLR1 mRNA levels were detected between SZ and HC. n.s., not significant; TLR, toll-like receptor level, ***significant at P ≤ .005, two-sided. A chi-square test of independence was performed to examine the relation between diagnosis (control...

...Michael J Hurley; Elisa Menozzi; Sofia Koletsi; Rachel Bates; Matthew E Gegg; Kai-Yin Chau; Hervé M Blottière; Jane Macnaughtan; Anthony H V Schapira toll-like receptors free fatty acid receptors short-chain fatty acids enteroendocrine cells microbiome Aligning Science Across Parkinson’s...

... of monocyte-derived DCs (Mo-DCs) from patients with limited cutaneous SSc (lcSSc), diffuse cutaneous SSc (dcSSc) and healthy controls (HCs) after stimulation with toll-like receptor (TLR) agonists. Also, using co-culture assays, we analysed T cell subpopulations after contact with autologous TLR-activated Mo...

... such as imiquimod. These TLRs signal through nuclear factor κB, leading to pro-inflammatory cytokine release. Abstract SSc is an autoimmune disease that has features of vascular abnormalities, inflammation and skin and lung fibrosis. Toll-like receptors (TLRs) are sentinel receptors that serve to recognize...

... Toll-like receptor (TLR)–associated chronic inflammation in fish, the underlying mechanism is not well understood. Objectives This study aimed to explore the role of Tlr22 in the innate immunity of large yellow croaker and investigate the anti-inflammatory effects of DHA on Tlr22-triggered...

... immune genes, the current understanding of the phenomenon in non-MHC immune genes is far from solid. In this review, we focus on Toll-like receptors (TLRs), innate immune genes directly involved in pathogen recognition and immune response activation, as there is a growing body of research...

... will have imposed differential selective pressures on the penguin immune system. At the front line of pathogen detection and response, the Toll-like receptors (TLRs) provide insight into host evolution in the face of microbial challenge. TLRs respond to conserved pathogen-associated molecular patterns...

.... Figure 4. Associations of plasma triglyceride concentration with the presence of TLR3*1 (A) and TLR3*11 (B) nucleotide sequence variants. Means ± SE are shown and sample sizes are reported for each group. Abstract Toll-like receptors (TLRs) are a crucial component of vertebrate innate immune response...

... was the significant decline in the immunohistochemical abundance of podocin and the significant upregulation of smoothening in the aging camels’ kidneys. However, the nonsignificant changes have reported for nephrin, calbindin, autophagy 5 (ATG5), aquaporin 1, and toll-like receptor 9. Furthermore, the mRNA...

..., and colon. Inflammatory grade was assessed by histopathology, immunohistochemistry, and chemokine analysis. The expression of Toll-like receptors (TLR) in mucosa was immunohistochemically evaluated. Antibody levels against bacterial ligands (lipopolysaccharide [LPS] and flagellin) were measured in sera...

... are degraded during an inflammatory response. LPS nonsense mediated decay post-transcriptional regulation RNA decay toll-like receptors Cancer Institute NSW 10.13039/501100001171 Western Sydney University Women’s fellowship South West Sydney Research Grant CINSW Future Research Leader...

... in both mice and humans. These studies never achieved full resistance to tumor relapse. Herein, we describe a repetitive RM-1 murine tumor rechallenge model for recurrence in humans. Using this newly developed model, we show that priming with tumor antigen-pulsed, Toll-like receptor (TLR)2 ligand...

...Virag Sharma; Nikolai Hecker; Felix Walther; Heiko Stuckas; Michael Hiller; Meredith Yeager Corresponding author: E-mail: [email protected] . innate immunity toll-like receptors TLR5 flagellin gene loss Toll-like receptor (TLR) proteins are an important component of the innate immune...

.... 2012 ; Sallaberry-Pincheira et al. 2016 ). Increasingly, however, the Toll-like receptors (TLRs) are recognized as important monogenic determinants of disease-resistance phenotypes, and are therefore important operands for natural selection ( Grueber et al. 2014 ). Toll-like receptors are the best...