... of adults with newly-treated HTN using linked EHR+claims data from OneFlorida+ Consortium. We included Florida Medicaid & Medicare-recipients diagnosed with HTN and prescribed ≥1 first-line antihypertensive during 2013-2020. We used generalized linear models to estimate differences in total therapeutic...

... therapeutic response and optimise outcomes in patients with Crohn’s disease (CD). We aimed to describe the durability of anti-TNF therapy in patients with CD receiving escalated anti-TNF therapy, along with overall durability of anti-TNF treatment between patients managed with a proactive versus reactive...

... on the use of innate immune signalling for modulation of cell fate by mRNA therapeutics. All other authors have nothing to disclose. 06 09 2024 10 12 2024 06 02 2025 08 04 2025...

... immunotherapy therapeutic vaccine immune checkpoint inhibitors Intramural Program of the Center for Cancer Research National Cancer Institute 10.13039/100000054 NIH 10.13039/100000002 ZIA BC 010666 Cooperative Research and Development Agreements Lessons learned In this small study...

... rabies in Milwaukee in 2004, the approach dubbed the “Milwaukee protocol” has been aggressively promoted as an effective therapy. The protocol has included therapeutic (induced) coma, ketamine, ribavirin, and amantadine and details of the protocol have changed over time. Over the past 2 decades...

... studies reporting the intervention effect on the same outcome were included in the pairwise meta-analysis. Studies that did not have a control group (active inert control or usual care) or did not compare an alternate domain of therapeutic lifestyle changes were excluded from the analysis and were...

... dysfunction, critically impeding wound repair. We developed a multifunctional hydrogel (DPFI) engineered for sequential therapeutic actions, including antibacterial, anti-inflammatory, antioxidant, pro-vascularization/epithelialization, and glycemic-regulating properties, to address these complications...

... University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Objectives To determine the value of on-site deep learning-based CT-derived fractional flow reserve (CT-FFR) for therapeutic management and adverse clinical outcomes...

..., contributed to XRT-resistance. Combining trametinib-rapamycin with XRT significantly enhanced therapeutic efficacy in PDX models and prevented or delayed resistance development. Conclusion PI3K-mTOR activation promotes the development of XRT-resistance in pediatric BRAF^V600E...

...—for further information please contact [email protected]. Abstract The mental health of young adults is well recognized as requiring serious attention in research and consequently health policy. At the same time, social media has been demonstrated to create therapeutic and non-therapeutic...

... panels. Graphical Abstract Graphical Abstract JAK inhibitors flow cytometry STAT cytokines therapeutic drug monitoring Takeda Canada 10.13039/100016040 More than 200 germline mutations, somatic mutations, and polymorphisms in JAK and STAT genes are linked to human diseases...

... Therapeutics. 2025 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( https://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work...

... wall of the left ventricle. Therapeutic drug monitoring did not reveal excessive midostaurin plasma levels, and hence, initially suspected drug interaction with posaconazole administered for antifungal prophylaxis was considered less likely to be causative. After discontinuing midostaurin, clinical...

... simulation, and personalized medicine are summarized. This review aims to offer perspectives and directions for understanding the mechanisms of intestinal health and disease as well as for developing innovative therapeutic strategies. organoid intestinal disease personalized medicine therapeutic strategy...

..., residents, staff, and researchers collaborated to develop, implement, and evaluate therapeutic recreation programming in a permanent supportive housing facility for older people with experiences of homelessness (n=68). Research Design and Methods A community advisory group ‘The Exchange,’ co-designed...

... ]. Abstract Objectives Studies supporting therapeutic drug monitoring to biopharmaceuticals in SLE are scarce. We aimed to assess anti-drug antibody (ADA) occurrence in belimumab-treated SLE patients and associations between belimumab concentrations and clinical response, serological outcomes and adverse...

... ) pediatric inflammatory bowel disease infliximab therapeutic dose monitoring Children’s Medical and Research Foundation, Ireland Address correspondence to: Emily Stenke, MB, BCh, BAO, PhD, National Centre for Pediatric Gastroenterology, Children's Health Ireland at Crumlin Cooley Road, Dublin 12, Ireland...

... countries. Poor outcomes are associated with undernutrition. Nutritional supplementation may be beneficial. We examined the effect of supplementation with lipid-based ready-to-use therapeutic food (RUTF) on the body composition of children with severe pneumonia. Non-severely malnourished children (6–59...

... of target enzymes within the folate, pyrimidine, and purine pathways, leading to MTX’s anti-proliferative effects in leukemia. Additionally, MTX’s sustained activity promotes the accumulation of anti-inflammatory adenosine, believed to mediate its therapeutic effects in IMIDs. In (pediatric) IBD...

... the potential to improve disease control and survival in patients with HCC with PVTT. hepatocellular carcinoma thrombosis radiotherapy tyrosine kinase inhibitors immune checkpoint inhibitors therapeutic chemoembolization Liver cancer is the sixth leading site and the third common cause of mortality among...