Skip to results
Modify your search
NARROW
1-20 of 43
Keywords: tetrodotoxin
Journal Article
Tetrodotoxin-mediated inactivation of medial prefrontal cortex decreases wakefulness and rapid eye movement sleep, and increases slow-wave sleep in rat Get access
in
Sleep
Sleep, Volume 48, Issue 3, March 2025, zsae260, https://doi.org/10.1093/sleep/zsae260
Published: 06 November 2024
...Trent Groenhout; Sumegha Ponnaluri; Lana Sharba; Tiecheng Liu; Amanda Nelson; Viviane S Hambrecht-Wiedbusch; Giancarlo Vanini; Dinesh Pal Figure 1. Tetrodotoxin (156 µM) microinjection into the prelimbic region of the medial prefrontal cortex caused an immediate and lasting decrease in REM sleep...
Journal Article
Wheat germ agglutinin affinity chromatography enrichment and glyco-proteomic characterization of tetrodotoxin-binding proteins from the plasma of cultured tiger pufferfish (Takifugu rubripes)
Bioscience, Biotechnology, and Biochemistry, Volume 87, Issue 10, October 2023, Pages 1155–1168, https://doi.org/10.1093/bbb/zbad095
Published: 17 July 2023
.../standard_publication_model ) ABSTRACT Efficient enrichment of tetrodotoxin (TTX)-binding proteins from the plasma of cultured tiger pufferfish (Takifugu rubripes) was achieved by ammonium sulfate fractionation and wheat germ agglutinin (WGA) affinity chromatography. The enrichment efficiency was validated...
Journal Article
Aposematic coloration of Pacific newts (Taricha) provides a qualitatively but not quantitatively honest signal to predators
Biological Journal of the Linnean Society, Volume 139, Issue 1, May 2023, Pages 1–17, https://doi.org/10.1093/biolinnean/blad007
Published: 29 March 2023
... among amphibians, which are often protected by harmful toxins. Pacific newts (Taricha) are considered a model of aposematism because when threatened, they arch the head and tail upwards to expose a vivid orange ventrum against a dark dorsum. Given that newts are defended by tetrodotoxin (TTX...
Journal Article
FEATURED
Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Acute Toxicity of Tetrodotoxin in Rodents
Toxicological Sciences, Volume 187, Issue 1, May 2022, Pages 127–138, https://doi.org/10.1093/toxsci/kfac022
Published: 26 February 2022
... physiologically based kinetic model for tetrodotoxin. Abstract In this study, the ability of a new in vitro/in silico quantitative in vitro–in vivo extrapolation (QIVIVE) methodology was assessed to predict the in vivo neurotoxicity of tetrodotoxin (TTX) in rodents...
Journal Article
The geographic mosaic of arms race coevolution is closely matched to prey population structure
Evolution Letters, Volume 4, Issue 4, 1 August 2020, Pages 317–332, https://doi.org/10.1002/evl3.184
Published: 01 August 2020
... coevolution may influence local trait differences, phenotypic variation can also result from other factors, like historical biogeography and local environmental conditions. Common garter snakes (Thamnophis sirtalis) evolved resistance to tetrodotoxin (TTX), a deadly neurotoxin found in their prey...
Journal Article
Large-effect mutations generate trade-off between predatory and locomotor ability during arms race coevolution with deadly prey
Evolution Letters, Volume 2, Issue 4, 1 August 2018, Pages 406–416, https://doi.org/10.1002/evl3.76
Published: 01 August 2018
... cited. The moral rights of the named author(s) have been asserted. Antagonistic pleiotropy sodium channel (NaV1.4) trade-offs tetrodotoxin (TTX) Society for Integrative and Comparative Biology Grant-in-Aid of Research American Museum of Natural History 10.13039/100005835...
Journal Article
Convergent adaptation to dangerous prey proceeds through the same first-step mutation in the garter snake Thamnophis sirtalis Get access
in
Evolution
Evolution, Volume 71, Issue 6, 1 June 2017, Pages 1504–1518, https://doi.org/10.1111/evo.13244
Published: 01 June 2017
... to two independent outcomes of tetrodotoxin (TTX) resistance in separate geographic lineages of the common garter snake (Thamnophis sirtalis) that coevolved with toxic newts. Resistance is largely conferred by amino acid changes in the skeletal muscle sodium channel (NaV1.4...
Journal Article
Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels
Toxicological Sciences, Volume 155, Issue 1, January 2017, Pages 112–123, https://doi.org/10.1093/toxsci/kfw187
Published: 21 September 2016
... that exposure of microglia to the pyrethroid pesticides, permethrin and deltamethrin, would activate microglia and increase the release of TNF-α. BV2 cells or primary microglia were treated with 0–5 µM deltamethrin or permethrin in the presence or absence of tetrodotoxin (TTX), a VGSC blocker for 24–48 h. Both...
Journal Article
An overview on the origin and production of tetrodotoxin, a potent neurotoxin Get access
Journal of Applied Microbiology, Volume 119, Issue 4, 1 October 2015, Pages 907–916, https://doi.org/10.1111/jam.12896
Published: 01 October 2015
.../funder_policies/chorus/standard_publication_model ) Summary Tetrodotoxin (TTX) is a deadly neurotoxin which selectively inhibits Na+ activation mechanism of nerve impulse, without affecting the permeability of K+ ions. Because of this sodium channel blocking action, it is majorly being...
Journal Article
Characterization and evolutionary analysis of tributyltin‐binding protein and pufferfish saxitoxin and tetrodotoxin‐binding protein genes in toxic and nontoxic pufferfishes Get access
Journal of Evolutionary Biology, Volume 28, Issue 5, 1 May 2015, Pages 1103–1118, https://doi.org/10.1111/jeb.12634
Published: 01 May 2015
... Understanding the evolutionary mechanisms of toxin accumulation in pufferfishes has been long‐standing problem in toxicology and evolutionary biology. Pufferfish saxitoxin and tetrodotoxin‐binding protein (PSTBP) is involved in the transport and accumulation of tetrodotoxin and is one of the most intriguing...
Journal Article
RT-PCR- and MALDI-TOF Mass Spectrometry-Based Identification and Discrimination of Isoforms Homologous to Pufferfish Saxitoxin- and Tetrodotoxin-Binding Protein in the Plasma of Non-Toxic Cultured Pufferfish (Takifugu rubripes) Get access
Bioscience, Biotechnology, and Biochemistry, Volume 77, Issue 1, 23 January 2013, Pages 208–212, https://doi.org/10.1271/bbb.120701
Published: 23 January 2013
...Ryohei TATSUNO; Kenichi YAMAGUCHI; Tomohiro TAKATANI; Osamu ARAKAWA Biosci. Biotechnol. Biochem., 77 (1), 208 212, 2013 Note RT-PCR- and MALDI-TOF Mass Spectrometry-Based Identi cation and Discrimination of Isoforms Homologous to Pu er sh Saxitoxin- and Tetrodotoxin-Binding Protein in the Plasma...
Journal Article
Puffer fish poisoning in Bangladesh: clinical and toxicological results from large outbreaks in 2008 Get access
Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 105, Issue 2, February 2011, Pages 74–80, https://doi.org/10.1016/j.trstmh.2010.10.002
Published: 01 February 2011
...: [email protected] (U. Kuch). 23 5 2010 1 10 2010 1 10 2010 2010 Royal Society of Tropical Medicine and Hygiene Abstract Poisoning after eating puffer fish containing highly lethal tetrodotoxin (TTX) is widespread in Asia. In 2008, naïve inland populations in Bangladesh were exposed...
Journal Article
Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family
Molecular Biology and Evolution, Volume 25, Issue 6, June 2008, Pages 1016–1024, https://doi.org/10.1093/molbev/msn025
Published: 06 February 2008
... tetrodotoxin (TTX) and saxitoxin (STX) via parallel amino acid replacements across all 8 sodium channels present in teleost fish genomes. This resulted in diverse suites of coexisting sodium channel types that all confer varying degrees of toxin resistance, yet show remarkable convergence among genes...
Journal Article
Functional Expression of Ion Channels in Mesenchymal Stem Cells Derived from Umbilical Cord Vein Get access
in
Stem Cells
Stem Cells, Volume 25, Issue 8, August 2007, Pages 2044–2052, https://doi.org/10.1634/stemcells.2006-0735
Published: 24 May 2007
...% of hUC-MSCs. Elevation of external potassium ion concentration increased the Kir current amplitude and positively shifted its reversal potential. In addition, inward Na+ current (INa) was found in these cells (∼30%); the current was blocked by tetrodotoxin and verapamil...
Journal Article
Miniature Synaptic Currents Become Neurotoxic to Chronically Silenced Neurons Get access
Cerebral Cortex, Volume 17, Issue 6, June 2007, Pages 1292–1306, https://doi.org/10.1093/cercor/bhl037
Published: 11 July 2006
...Ianai Fishbein; Menahem Segal © The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected] 2007 Abstract When deprived of spontaneous ongoing network activity by chronic exposure to tetrodotoxin (TTX...
Journal Article
Antinociceptive effects of tetrodotoxin (TTX) in rodents
BJA: British Journal of Anaesthesia, Volume 96, Issue 6, June 2006, Pages 761–768, https://doi.org/10.1093/bja/ael096
Published: 04 May 2006
...J. Marcil; J.-S. Walczak; J. Guindon; A. H. Ngoc; S. Lu; P. Beaulieu pain, inflammatory pain, neuropathic pain, visceral sodium channel blocker, tetrodotoxin Pain is the most common symptom encountered in clinical practice. The use of currently available drugs to treat pain is often associated...
Journal Article
Ion Channels in Mesenchymal Stem Cells from Rat Bone Marrow Get access
in
Stem Cells
Stem Cells, Volume 24, Issue 6, June 2006, Pages 1519–1528, https://doi.org/10.1634/stemcells.2005-0307
Published: 16 February 2006
...+ current (Ito). In addition, tetrodotoxin (TTX)-sensitive sodium current (INa.TTX) and nifedipine-sensitive L-type Ca2+ current (ICa.L) were found in a small population of rat MSCs. Moreover, reverse transcription-polymerase chain reaction revealed the molecular...
Journal Article
Influence of Tetrodotoxin Inactivation of the Central Nucleus of the Amygdala on Sleep and Arousal Get access
in
Sleep
Sleep, Volume 28, Issue 8, August 2005, Pages 923–930, https://doi.org/10.1093/sleep/28.8.923
Published: 01 August 2005
... with electrodes for recording the electroencephalogram (EEG) and electromyogram (EMG), and with guide cannulae aimed into CNA. Sleep was recorded for 22 h (10 h light, 12 h dark) following microinjections of tetrodotoxin (TTX: 5.0 ng/0.2 µl given unilaterally [TTXUH] or bilaterally [TTXBH], and 2.5 ng/0.1 µl...
Journal Article
Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons Get access
in
Brain
Brain, Volume 128, Issue 9, September 2005, Pages 2189–2199, https://doi.org/10.1093/brain/awh574
Published: 15 June 2005
... Module TTX = tetrodotoxin VGlut-1 = glutamate transporter-1 VZ = ventricular zone A hallmark of neurons is the ability to generate action potentials, i.e. excitability ( Reh, 2002 ). Neuronal excitability depends on four factors ( Hodgkin and Huxley, 1952 ; Spitzer et al., 2002 ): (i...
Journal Article
Co‐localization of sodium channel Nav1.6 and the sodium–calcium exchanger at sites of axonal injury in the spinal cord in EAE Get access
in
Brain
Brain, Volume 127, Issue 2, February 2004, Pages 294–303, https://doi.org/10.1093/brain/awh032
Published: 01 February 2004
... channels and NCX in axonal degeneration in neuroinflammatory disorders has been suggested by the protective effect of low doses of the sodium channel blockers lidocaine and flecainide ( Kapoor et al., 2003 ) and tetrodotoxin (TTX) ( Garthwaite et al., 2002 ) and of the NCX blocker...
