... of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Abstract Aims Tetrahydrobiopterin (BH₄) is a critical determinant of the biological function of endothelial nitric oxide...

... by endothelial NOS [ 26 ] and is a measure of redox balance. We have previously demonstrated elevated plasma phenylalanine in children and adults with falciparum malaria [ 13 ]. In addition, we showed that systemic levels of urinary tetrahydrobiopterin (BH₄), an essential cofactor required...

...Gillian Douglas; Ashley B Hale; Jyoti Patel; Surawee Chuaiphichai; Ayman Al Haj Zen; Victoria S Rashbrook; Lucy Trelfa; Mark J Crabtree; Eileen McNeill; Keith M Channon Abstract Aims GTP cyclohydrolase I catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4...

...). Tetrahydrobiopterin (BH₄), synthesized by its rate-limiting enzyme – GTP cyclohydrolase I (GTPCH I) via a de novo pathway, is an essential cofactor for NOS. The production of NO can be accelerated by BH₄ through stabilizing the binding between NOS and its substrates. Although...

... by Oxford University Press. All rights reserved. For permissions, please email: [email protected] 2016 Abstract Background and Aims: Guanosine triphosphate cyclohydrolase [GCH1] governs the production of the enzyme cofactor tetrahydrobiopterin [BH4] which is essential for biogenic amine...

... vessel wall, NO is mainly formed in endothelial cells from l-arginine by enzymatic activity of endothelial NO synthase (eNOS). ^{10 , 11} It is well established that tetrahydrobiopterin (BH₄) is an essential cofactor for allosteric and redox activation of eNOS enzymatic...

... rate and response to exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required cofactor for enzymes with roles in cardiac autonomic function, including tyrosine hydroxylase and nitric oxide synthase. Synthesis of BH4 is regulated by GTP cyclohydrolase I (GTPCH...

...Yanti Octavia; Natascha L. Assman; An L. Moens © The Author 2011. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved 2011 Tetrahydrobiopterin Cardiopulmonary bypass Myocardial function Endothelial function Nitric oxide...

... vehicle-treated animals served as controls. Fig. 1 Timeline of the experiment. Schematic representation of the experiment timeline (CPB: cardiopulmonary bypass, BH4: tetrahydrobiopterin). The dogs were premedicated with propionylpromazine and anesthetized with pentobarbital (15 mg kg⁻¹...

...-adenine-dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), and (6R-)5,6,7,8-tetrahydrobiopterin (BH₄). All NOS bind calmodulin and contain haem. Neuronal NOS (nNOS, NOS I) is constitutively expressed in central and peripheral neurons...

..., serotonin) may cause the ultradian sleep-wake rhythm. Sepiapterin reductase deficiency hypersomnia melatonin ultradian sleep-wake rhythm tetrahydrobiopterin serotonin SEPIAPTERIN REDUCTASE DEFICIENCY (SRD) IS A RARE, AUTOSOMAL, RECESSIVE, METABOLIC DISORDER THAT RESULTS FROM MUTATIONS...

... tetrahydrobiopterin (BH₄) emerging as a critical determinant of NO synthesis. ⁶ Indeed, in the absence of adequate levels of BH₄, NOS3 becomes uncoupled from l-arginine oxidation and, instead, molecular oxygen is reduced to form superoxide anion (O₂...

... renal perfusion with DCFH-DA and diaminorhodamine-4M acetoxymethyl ester with l-arginine. The dimeric form of eNOS was measured by low-temperature sodium dodecyl sulfate–polyacrylamide gel electrophoresis. Serum tetrahydrobiopterin (BH4) concentrations were determined by high-performance liquid...

.... All rights reserved. For Permissions, please email: [email protected] 2007 Abstract Background. Chronic treatment with candesartan cilexetil (C) improves the outcome of rats after 5/6 nephrectomy (Nx). Tetrahydrobiopterin (BH4), an essential cofactor for appropriate...

...) or Dex (10 μg/rat/d) (David Bull Laboratories, Mulgrave, Victoria, Australia) was diluted in sterile saline and injected subcutaneously daily. Folic acid (0.04 g/L, around 5 mg/rat/d) (Sigma-Aldrich, St. Louis, MO) was added to tap water for drinking. 6R-tetrahydrobiopterin (10 g/L) (Schircks...

... BH₄ is decreased during CPB leading to an uncoupling of NOS which could be improved by BH₄ administration. Tetrahydrobiopterin (BH₄) is an essential cofactor of nitric oxide biosynthesis. Decreased levels of BH₄ lead to an uncoupling of NO synthase (NOS), with a shift...

.... Hermann T. Kober L. Torp-Pedersen C. Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects Am J Physiol Heart Circ Physiol 2003 285 2 H875 H882 [5] Khoo J.P. Zhao L. Alp N.J. Bendall J.K. Nicoli T...

... Society. 2006 Abstract Tyrosine hydroxylase (TH), an iron-containing enzyme, catalyzes the first and rate-limiting step of catecholamine biosynthesis, and requires tetrahydrobiopterin (BH4) as a cofactor. We found that preincubation of recombinant human TH with BH4 results in the irreversible...

...-Arg), the co-factor tetrahydrobiopterin (H₄B) or molecular oxygen may lead to lower NO levels, which enhances the development of adhesion phenotype. METHODS: We utilized high-performance liquid chromatography (HPLC) and immunoprecipitation with nitrotyrosine antibody to determine the levels...

...Yoko Tanaka; Noriko Nakagawa; Seiki Kuramitsu; Shigeyuki Yokoyama; Ryoji Masui AFRPT, 2-amino-5-formylamino-(6β)-ribosylamino-4(3H)-pyrimidinone 5′-triphosphate BH₄, tetrahydrobiopterin DRPT, 2,5-diamino-(6β)-ribosylamino-4(3H)-pyrimidinone 5′-triphosphate FapyG, 2,6...