...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Despite decades of advancements in diagnostic MRI, 30%–50% of temporal lobe epilepsy (TLE) patients remain categorized as ‘non-lesional’ (i.e. MRI negative) based on visual assessment by human experts. MRI-negative patients face diagnostic...

... neurological disorders including Alzheimer’s, Parkinson’s and Epilepsy. Here, we investigate alpha rhythm slowing in individuals with refractory temporal lobe epilepsy compared with healthy controls, using scalp EEG and magnetoencephalography. We retrospectively analysed data from 17 (46) healthy controls...

... an abstract non-social synonym judgement task with items matched to the social concepts for lexical frequency, imageability and semantic diversity. ^{32 , 72} behavioural variant frontotemporal dementia semantic dementia social concept temporal lobe epilepsy trans-diagnostic Medical Research...

... Abstract Convolutional neural networks (CNN) show great promise for translating decades of research on structural abnormalities in temporal lobe epilepsy into clinical practice. Three-dimensional CNNs typically outperform two-dimensional CNNs in medical imaging. Here we explore for the first time whether...

... year post-surgery using both the ILAE and Engel classification scales. ^{18 , 19}   Table 1 shows clinical information for all patients. Abstract Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order to lateralize...

... dementia temporal lobe epilepsy Corresponding author: Matthew A. Rouse, MRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge CB2 7EF, United Kingdom. 01223 766166. Email: [email protected] 20 04 2024 24 07 2024 26 07 2024 © The Author(s...

...Nigel P Pedersen; Ashley Raghu; Veeresh Kumar N Shivamurthy; Joshua J Chern; Robert E Gross; Jon T Willie; Raymond J Dingledine; Ammar Kheder The piriform cortex (PC) has garnered significant attention in the context of medial temporal lobe epilepsy (mTLE), primarily driven by three key lines...

... relevant feature. Here, we exploited the exponent of the aperiodic component of the power spectrum of the electroencephalography (EEG) signal, as a non-invasive and cost-effective proxy of the E/I balance. We recorded resting-state activity with high-density EEG from 67 patients with temporal lobe epilepsy...

[email protected] Abstract Considering the growing age of the world population, the incidence of epilepsy in older adults is expected to increase significantly. It has been suggested that late-onset temporal lobe epilepsy (LO-TLE) may be neurodegenerative in origin and overlap with Alzheimer’s disease (AD). Herein...

.... Abstract Temporal lobe epilepsy is a brain network disorder characterized by alterations at both the structural and the functional levels. It remains unclear how structure and function are related and whether this has any clinical relevance. In the present work, we adopted a novel methodological approach...

..., the underlying mechanism remains elusive. Methods We studied HRV, spontaneous recurrent seizures, and depression-like behaviors in different phases of pilocarpine-induced temporal lobe epilepsy (TLE) in mice. Single-cell RNA sequencing analysis was used to identify various nerve cell subsets in TLE mice...

... and cerebellar volumes were based on the probabilistic atlas from Freesurfer. Matrices were calculated based on the partial correlations between node volumes controlling for ICV. Abstract The relationship between temporal lobe epilepsy and psychopathology has had a long and contentious history with diverse...

...-mail: [email protected] Robyn M Busch and Lamis Yehia contributed equally to this work. Abstract Memory dysfunction is prevalent in temporal lobe epilepsy, but little is known about the underlying pathophysiological etiologies. Here, we use spatial quantitation to examine differential expression...

... and generalized than hypothesized by the lesion model. ^{4 , 5} For example, patients with temporal lobe epilepsy (TLE) demonstrate impairments in domains that are not typically associated with temporal lobe damage (i.e. executive function) and those with frontal lobe epilepsy demonstrate impairments...

...; Friedrich Woermann; Jan Bauer; Christian G Bien Anna R. Tröscher, Katharina M. Mair, Jan Bauer and Christian G. Bien contributed equally to this work. Tröscher et al. show that in patients with GAD65 antibody-associated temporal lobe epilepsy, cytotoxic T cells attack and kill neurons...

.... Abstract Together with hippocampus, the amygdala is important in the epileptogenic network of patients with temporal lobe epilepsy. Recently, an increase in amygdala volumes (i.e. amygdala enlargement) has been proposed as morphological biomarker of a subtype of temporal lobe epilepsy patients without MRI...

... relationship to seizures and memory loss. leucine-rich glioma-inactivated 1 (LGI1) autoantibodies limbic encephalitis autosomal-dominant lateral temporal lobe epilepsy k_v1 channels Institut National pour la Science et la Recherche Médicale 10.13039/501100001677 Agence Nationale de la...

... science, Caciagli et al. identify impaired activation of attentional and executive areas and impaired default-mode deactivation as key neural processes mediating cognitive impairment and capture distinct functional signatures in frontal versus temporal lobe epilepsy. frontal lobe epilepsy...

... that patients use this cognitive ability when deciding between various treatment options, but this assumption has not been robustly tested. The temporal lobes are key contributors to this ‘future thinking’ and its building blocks include cognitive functions commonly impaired in temporal lobe epilepsy...

.../chorus/standard_publication_model ) Abstract Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has been widely used as an effective treatment for refractory temporal lobe epilepsy. Despite its promising clinical outcome, the exact mechanism of how ANT-DBS alleviates seizure...