... will facilitate any type of experiment using antibody detection of proteins that would benefit from enhanced sensitivity. Drosophila vGlut synaptic vesicle epitope tag FlyBase National Institutes of Health 10.13039/100000002 2R01GM115510 Proteins mediate biological function. To understand...

... trigger like light. Here, we give an overview of such methods developed and used in the nematode Caenorhabditis elegans. cell ablation optogenetics chemical ablation channelrhodopsins animal rhodopsins photosensitizer laser ablation genetic ablation hyperpolarization synaptic vesicle...

... (both familial and sporadic). Synaptopathies are diseases resulting from physiological dysfunction of synapses, and define the earliest stages in multiple neuronal diseases, with synapse loss a key feature in dementia. At the presynapse, the process of synaptic vesicle recruitment, fusion and recycling...

...://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/ ). Abstract Synaptic vesicle (SV) exocytosis is orchestrated by protein machineries consisting of the SNARE complex, Ca²⁺ sensors, and their partners. Secretagogin (SCGN) is a Ca²⁺-binding protein involved in multiple forms of vesicle...

... to the AZ ( Figure 1 K and M), while SV2A-labeled gold particles accumulated near the AZ ( Figure 1 L and N). For each SIP or synaptic vesicle, we measured the shortest distance to the AZ in SV2B- or SV2A-labeled sections ( Figure 1 H and I). If SV2 is assumed to be present on every vesicle throughout...

... function and how information is processed to generate behavior. Here, we describe and characterize smFLAG-vGlut, a conditional marker of glutamatergic synaptic vesicles for the Drosophila model system. smFLAG-vGlut is validated for functionality, conditional expression, and specificity...

... are not limited to missense alleles; rather, they are a property of most or all severe cha-1 hypomorphs. We suggest that our data are consistent with a model of ChAT protein physically, but not covalently, associated with synaptic vesicles; and there is a temperature-dependent equilibrium between vesicle...

... characteristic (ROC), we analyzed the risk factors and diagnostic power for discriminating PD from HC and PPS. Results We identified 1333 genes that were significantly different between PD and HCs based on seven microarray datasets. The identified MEturquoise module is related to synaptic vesicle trafficking...

... This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Abstract The release of neurotransmitters from synaptic vesicles (SVs) at pre...

... ) Abstract Synaptic vesicles (SVs) transmit signals by releasing neurotransmitters from specialized synaptic regions of neurons. In the synaptic region, SVs are tightly clustered around small structures called active zones. The motor KIF1A transports SVs outward through axons until they are captured...

...-specific manner. Abstract Synaptotagmin 1 (SYT1) is a critical mediator of fast, synchronous, calcium-dependent neurotransmitter release and also modulates synaptic vesicle endocytosis. This paper describes 11 patients with de novo heterozygous missense mutations in SYT1. All mutations...

.... The unusual combination of structural features in VPMdm synapses is likely to contribute significantly to the high efficacy, strength, and plasticity of these thalamocortical synapses. dendritic spines serial electron microscopy somatosensory synaptic vesicle pool thalamus Long-range projection neurons...

.... However, cholesterol depletion using methyl-β-cyclodextrin (MβCD) sensitized synaptic vesicle protein 2 and BoNT/A. Also...

...) on the postsynaptic muscle surface ( Figure 1A ). AZs are readily identifiable by electron microscopy (EM) as electron-dense T-bar structures ( Feeney et al. 1998 ) ( Figure 1A ). The precise matching of AZ to GluR cluster has allowed optical imaging of synaptic vesicle (SV) release at individual release...

... potential; TTX, tetrodotoxin; Vhold, holding potential. Embryonic stem cells Dopamine Electrophysiology Synaptic vesicle Quantum dots NIH 10.13039/100000002 DA025143 OD008761 NS075893 As one of the major neurotransmitters, dopamine (DA) plays an important role in various brain functions including...

... and function by status epilepticus, which could contribute to the development of the chronic epileptic state and may represent a potential new target for antiepileptic therapies. epilepsy neurotransmitter release hippocampus synaptic vesicle recycling mossy fibre terminals Rats and mice 1–2 months post...

...^−/−) mice. Electron microscopy revealed that there were significantly greater numbers of readily releasable synaptic vesicles present in Ctsd^−/− mice than in wild-type control mice as early as postnatal day 16. The size of this synaptic vesicle pool continued to increase with disease...

..., in part, by the Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary Faculty of Medicine, Calgary, Alberta, Canada. Copyright © 2010 by the American Association of Neuropathologists, Inc. 2010 Abstract To assess the synaptic vesicle protein synaptophysin...

[email protected]. 2010 Abstract Synaptic vesicle protein 2A (SV2A) has been identified as the binding site for the antiepileptic drug levetiracetam and is thought to decrease neuronal excitability. Since knockout of SV2A in mice leads to seizures, we hypothesized that a reduction in SV2A expression promotes...

[email protected] 30 6 2005 4 10 2005 23 10 2005 Drug abuse exocytosis plasticity psychostimulant schizophrenia sensitization synaptic vesicle © 2006 Collegium Internationale Neuropsychopharmacologicum 2006 ARTICLE International Journal of Neuropsychopharmacology (2006), 9, 751–759. Copyright f...