... [email protected]. 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Objective Prior studies have reported the loss of α-smooth muscle actin (α...

..., distinct and redundant mechanisms of TGFβ isoforms in TAAD incidence and severity remain elusive. Objective Here we examined the biological role of TGFB2 in smooth muscle cell (SMC) differentiation and investigated how TGFB2 defects can lead to regional TAAD manifestations. Methods To characterize...

... dispersion term. We study bright solitary waves with smooth profiles that extend from the limit where the dependence of the dispersion coefficient on the wave intensity is negligible to the limit where the solitary wave becomes singular due to vanishing dispersion coefficient. We analyse and numerically...

... University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) contraction fertility oviduct progesterone receptor smooth muscle cell Eunice Kennedy Shriver National Institute of Child Health and Human Development 10.13039/100009633...

... in patients with diabetes or CKD. ⁹ Accumulating evidence indicates that vascular calcification is an active, highly regulated process. ^10–12 In this context, mediators regulate the underlying calcium phosphate deposition and transdifferentiation of vascular smooth muscle cells (VSMCs...

... [(smooth muscle tumors of uncertain malignant potential (STUMPs)] have been reported, with lung as the most common site. Herein, we describe pulmonary metastases of a uterine STUMP presenting as bullae in a female patient. Computed tomography revealed two pulmonary metastases in the left lung with several...

... from the aforementioned coefficient. To improve the computational complexity of the MLMC estimator in the case of highly oscillatory random fields we devise and implement a smoothing technique integrated into the circulant embedding method. This allows us to choose the coarsest mesh on the first level...

... Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Aims Vascular smooth muscle cells (VSMCs) are involved in the aetiology of atherosclerosis, but whether methyltransferase-like 3 (METTL3)–catalysed N⁶-methyladenosine (m⁶A...

... (ECs) and smooth muscle cells (SMCs) and explored their potential as biomarkers for human vascular disease. Methods and results Using high-throughput RNA sequencing and a de novo circRNA detection pipeline, we quantified the daily levels of 31 369 circRNAs in a 2-week differentiation...

... smooth muscle cell (α-SMA) antibody (Abcam, ab7817) and Fluorescein Isothiocyanate (FITC)-labeled Phalloidin (Solarbio, CA1620) staining. PASMCs were seeded onto coverslips for a period of 3 days. Subsequently, the cells were gently washed with phosphate-buffered saline (PBS) and then fixed using 4...

... and α-smooth muscle actin (α-SMA) in skin wound tissue in mice. Mouse skin fibroblasts (MSFs) stably transfected with Tet-on-Flag-RAMP1 overexpression (OE) and Tet-on-Flag control (Ctrl) lentiviruses were constructed for in vitro experiments. High mobility group AT-hook 1 (HMGA1) plasmids and α...

... PDE with smooth coefficients and right-hand side, and prove that it contains high-order approximations of all smooth PDE solutions. While the definition and the approximation properties of this space only require the governing PDE to have -smooth coefficients and right-hand side, being...

... and treatment of inguinal masses in AIS patients, emphasizing the need for further research and consensus in this area. androgen insensitivity syndrome (AIS) leiomyoma testis smooth muscle actin (SMA) Desmin Androgen insensitivity syndrome (AIS) is an X-linked disorder where an affected individual...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Strictures in inflammatory bowel disease, especially Crohn’s disease (CD), are characterized by increased intestinal wall thickness, which, according to recent accumulating data, is mainly attributed to the expansion of the intestinal smooth...

.... Piezo1 conditional knockout mice in vascular smooth muscle cells of MFS mice (MFS × CKO) was generated, and bioinformatics analysis and experiments in vitro and in vivo were performed to investigate the role of Piezo1 in MFS. Results PIEZO1 expression decreased...

... affect the smooth muscle cells (SMCs) comprising the vascular wall and the endothelial cells (ECs) lining the lumen. Pressure and flow are detected by mechanosensors in these cells and translated into appropriate responses to regulate blood pressure and flow. This review focuses on the role...

...—for further information please contact [email protected]. Abstract Background and Aims The role of vascular smooth muscle cells (SMCs) in atherosclerosis has evolved to indicate causal genetic links with the disease. Single cell RNA sequencing (scRNAseq) studies have identified multiple cell...

... smooth additive regression trees), an extension of gradient boosting machines with improved accuracy when the underlying function is smooth or the sample small or noisy. In extensive simulations, we find that the combination of smooth symmetric trees and of carefully designed priors gives SMARTboost...

... pathologies. However, its role in AVF remodeling, particularly concerning fibrotic remodeling, remains elusive. Methods MR expression and the phenotypes of vascular smooth muscle cells (VSMC) were assessed in dysfunctional AVF. The effects of MR on VSMC phenotypic switching were examined in vitro...

... Surveillance, Epidemiology, and End Results Program (SEER) website used to explore temporal effects of period and cohort on cancer incidence and mortality. It provides a graphical display of smoothed rates, and a C-P score that helps to assess the magnitude of the effect of cohort and period. This update...