... Objectives The pathobiology of restless legs syndrome (RLS) remains poorly understood, complicating effective treatment. This observational cross-sectional study aimed to identify a cerebrospinal fluid proteomic signature of RLS and to explore sex-specific differences in cerebrospinal fluid proteomics...

... a self-administered questionnaire and health checkup data. We defined insomnia based on the International Classification of Sleep Disorders, third edition, sleep apnea syndrome (SAS) with a simple 4-variable screening tool, and restless legs syndrome (RLS) with RLS/Willis-Ekbom disease diagnostic...

... of the patients had any additional significant medical or neurological disorder; therefore, none was taking other medications acting on the central nervous system. The score at the International Restless Legs Syndrome Study Group rating scale (IRLS) [ 19 ] was also obtained. We retrospectively recruited 66...

... of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Restless legs syndrome (RLS) is a sleep disorder characterized by an irresistible urge to move the legs, with pathogenesis involving genetic...

... Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria [ 23–25 ]. In total, we recruited 113 patients with RLS and 45 age and sex-matched controls for serologic α-syn assessments. Controls were often patients’ spouses or other non-genetically related people accompanying the patients. We collected...

... was to characterize LMM in restless legs syndrome (RLS) in order to better evaluate their impact on the neurophysiology of the disorder and, therefore, the possible clinical implications. Methods Consecutive, drug-free patients diagnosed with RLS and controls, aged 18 years or more, were retrospectively enrolled...

...Christopher J Earley; Diego García-Borreguero; Mark Falone; John W Winkelman Abstract Study Objectives Iron therapy is associated with improvements in restless legs syndrome (RLS). This multicenter, randomized, double-blind study evaluated the effect of intravenous ferric carboxymaltose (FCM...

... mutation, identified as Meis1^R272H (MEIS1 point mutation) mice, and characterized their phenotype. Since females are more prone to develop RLS, we focused on female mice. Abstract Restless legs syndrome (RLS) is a neurological disorder characterized by uncomfortable...

... underlying restless legs syndrome (RLS), neuroleptic-induced akathisia, and opioid withdrawal. These three conditions also share other clinical components suggesting some overlap in their pathophysiology. Recent prospective studies demonstrate the frequent incidence of RLS-like symptoms during opioid...

... and sleep-related disorders; however, its role in restless legs syndrome (RLS) is unclear. We hypothesized that similarly, in RLS the diffusivity in glymphatic system is decreased. Here, we aimed to evaluate glymphatic system functionality in patients with RLS, compare it to healthy controls, and analyze...

...-endorphin and perhaps Met-enkephalin, due to the non-selectivity of the methodology they employed. We did a review of the literature for relevant articles published in English in PubMed using the following terms: ‘Autopsy AND Restless Legs Syndrome’, Post-mortem’ AND Restless Legs Syndrome’, ‘Animal models...

.... Abstract Study Objectives The purpose of this study was to evaluate the efficacy and safety/tolerability of bilateral high-frequency tonic motor activation (TOMAC) in patients with medication-refractory restless legs syndrome (RLS). Methods RESTFUL was a multicenter, randomized, double-blind, sham...

... (TOMAC) for treatment of medication-refractory moderate-to-severe primary restless legs syndrome (RLS). Methods In the parent study (RESTFUL), adults with refractory RLS were randomized to active TOMAC or sham for 4 weeks followed by 4 weeks of open-label active TOMAC. In the extension study, earlier...

...Tae-Joon Kim; Min Hye Kim; Jung Hwan Kim; Jin-Sun Jun; Jung-Ick Byun; Jun-Sang Sunwoo; Jung-Won Shin; Sung-Min Gho; Chul-Ho Sohn; Ki-Young Jung Table 1. Clinical characteristics of 31 patients with restless legs syndrome Items Values in mean ± SD or number (%) Demographic factors...

... In addition to sensorimotor symptoms, hyperarousal is another main presentation of restless legs syndrome (RLS) and leads to fragmented sleep, insomnia, and daytime sleepiness. Moreover, interrupted sleep architecture is also recorded in patients with epilepsy. The interaction between RLS and epilepsy has...

...Jonathan Yeung Laiwah; John W Winkelman restless legs syndrome RLS augmentation dopamine agonist gabapentin opioid Figure 2. CGI-S at initial and final visits in Responders and Non-Responders. DAs were discontinued successfully in 59% (n = 29/49) of Responders compared to 36...

... Objectives To evaluate alterations of global and local structural brain connectivity in patients with restless legs syndrome (RLS). Methods Patients with primary RLS and healthy controls were recruited at a sleep center where they underwent diffusion tensor imaging (DTI) of the brain. We calculated...

... compiled a list of candidate gene variants by searching PubMed for genetic association studies published between 1996 and January 4, 2022. The search term “genetics AND restless legs syndrome” returned 383 publications. These were screened manually to identify case–control association studies in which...

... difference in the prevalence of cerebral palsy, Ehlers-Danlos Syndrome, ADHD, parasomnias, and depression between the three groups though there was a trend toward higher rates of comorbid ADHD (p = .06) in the PLMD group. Table 1. Demographic characteristics of RSD, Restless Legs Syndrome group...

... Restless legs syndrome (RLS) is common among patients with end-stage kidney disease (ESKD) and is associated with poor outcomes. Several recently published studies had focused on pharmacological and non-pharmacological treatments of RLS, but an updated meta-analysis has not been conducted. Methods...