... thus appears to have a limited role in zebrafish neural development. alternative splicing microexon compensation neural development Intramural Research Program 10.13039/100030692 National Institute for Child Health and Human Development 1ZIAHD008884-15 The diversity of cell types...

... was absent from 461 feline genomes, and genotypes at the PAX3:c.937C>T variant perfectly co-segregated with DBE, deafness and minimal white spotting in the Dutch line cats, however it was not found in DBE cats of the Topaz lineage. Felis catus whole-genome sequence neural development...

...Harold A Burgess; Edward A Burton zebrafish disease models neuroanatomy neural development CRISPR transgenics Correspondence addresses: Bldg 6B, Room 3B-308, 6 Center Drive, Bethesda, MD 20892, USA (HAB). E-mail: [email protected]; and 7015 BST3, 3501 Fifth Ave, Pittsburgh, PA 15213...

...-based model apoptosis cell migration cell proliferation cortical layer formation neural development Biological tissue often exhibits complex anatomical features that are shared across many species. One well-known example is the layered distribution of different cell types seen in the mammalian...

... identifies overrepresented annotations for neural development, microtubules, cytoskeleton, transcriptional regulation, and synapses. The same annotation categories, with the exception of transcriptional regulation, are overrepresented among the mRNAs that distinguish INP3 cells, but many of the mRNAs differ...

... cerebral cortex disease modeling embryonic stem cells GABAergic interneuron induced pluripotent stem cells neural development transplantation National Institute of Mental Health 10.13039/100000025 R01MH066912 F31NS108622 5F30MH105045 The cerebral cortex functions by an intricate mix...

... are related in the context of the lifetime neural development of human cognition and whether the neural network for reading is universal or different across languages. Our findings showed that a common network of left frontal and occipital regions typically involved in reading Chinese was recruited across all...

... through pathways regulated by Egr1, IGFBP3, TFPI2, and ADM. PAMAM dendrimers human neural progenitor cells neural development nano toxicology Dendrimers are at the forefront of research in nanoscience because of several interesting macromolecular system properties, such as their precise architecture...

... et al. 2015 ). planar cell polarity formin cytoskeleton neural development noncanonical Wnt signaling IN multicellular organisms, epithelia are polarized along the apical–basal axis as well as within the epithelial plane, imparting cells with a sense of direction. The latter polarity, planar...

... with abnormal child neural development during the first 7 years of life. These findings reinforce the importance of the early environment for neurodevelopment generally, and expand knowledge regarding the domains of neurodevelopment affected by environmental conditions. Further work is needed to determine...

... and neural developmental features of DS etiology and provide proof of concept for using DS iPSCs to test corrective therapeutic strategies for DS in vitro. Our results indicate that disease-specific iPSCs are indeed able to model phenotypes of complex human diseases in vitro. DS iPSCs thus...

... to advance our understanding of disease mechanisms. Likewise, studies of human embryonic and NSCs are helping to decipher the normal functions of AD-related genes; revealing intriguing roles in neural development. Neurodegeneration Transplantation Disease modeling Induced pluripotent stem cell...

...) displayed an increased rate of apoptosis in the Alkbh1^−/− NPCs when compared with wild-type cells. Whole-genome expression analysis and chromatin immunoprecipitation revealed that ALKBH1 regulates both directly and indirectly, a subset of genes required for neural development...

...Roman Bauer; Frederic Zubler; Andreas Hauri; Dylan R. Muir; Rodney J. Douglas Cx3D provides a sophisticated framework for simulating neural development in 3-dimensional (3D) space ( Zubler and Douglas 2009 ). Neurons are composed of discrete physical components such as spheres (somata) and chains...

... to effect the generation of a desired neural subtype. Embryonic stem cells Neural differentiation Serotonergic neurons Tissue-specific expression Lineage commitment Neural development Depending on the intended average integration number in the population (= mean occurrence of infection; MOI...

.... Neural development Embryonic stem cells Calcium signaling FGF/Erk pathway Nnat BMP pathway KCL start-up fund and a Taiwanese government (the Ministry of National Defense) fund MRC Career Development Fellowship G120/782 Charles Wolfson Charitable Trust During mouse embryogenesis...

... is that epigenetic mechanisms contribute to all levels of the hierarchical control of OR gene expression, especially the repressive events that seem to be necessary to achieve the singularity of OR gene choice. chromatin remodeling epigenetics olfaction olfactory receptor neural development A fundamental...

... after decapitation and the gonads were checked to ensure that all individuals included in the final sample were accurately sexed and had reached sexual maturity. By only including sexually mature individuals at the spawning season, we could control for the effect of neural development that can occur...

... antigens Fluorescence-activated cell sorting Immunomagnetic cell separation Cell therapy Parkinson disease Neural lineage Neural development Current neuronal differentiation protocols of human embryonic stem cells (hESC) are able to enrich for particular cell subtypes [ 1 – 3 ]. However...

... throughout 1 y of life for neural development. (n-3) fatty acids docosahexaenoic acid neural development The rationale for this study was that at ∼6 mo of age, infants are beginning to be fed semisolid foods and thus are likely to have a reduction in dietary DHA as reflected in decreased blood DHA levels...