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Journal Article
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Improved robustness to gene tree incompleteness, estimation errors, and systematic homology errors with weighted TREE-QMC
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Yunheng Han and Erin K Molloy
Systematic Biology, syaf009, https://doi.org/10.1093/sysbio/syaf009
Published: 25 February 2025
... code for weighted TREE-QMC is available on Github: ( https://github.com/molloy-lab/TREE-QMC ) species trees summary methods quartets gene tree error homology error missing data Accepted Manuscript Improved robustness to gene tree incompleteness, estimation errors, and systematic homology errors...
Journal Article
Estimating hypothetical estimands with causal inference and missing data estimators in a diabetes trial case study
Camila Olarte Parra and others
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Biometrics
Biometrics, Volume 81, Issue 1, March 2025, ujae167, https://doi.org/10.1093/biomtc/ujae167
Published: 28 January 2025
... the estimators. We discuss various considerations relevant when choosing an estimation approach, including computational time, how to handle missing data, whether to include post intercurrent event data in the analysis, whether and how to adjust for additional time-varying confounders, and whether and how...
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High-dimensional multiple imputation (HDMI) for partially observed confounders including natural language processing-derived auxiliary covariates
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Janick Weberpals and others
American Journal of Epidemiology, kwaf017, https://doi.org/10.1093/aje/kwaf017
Published: 22 January 2025
.... HDMI approaches may decrease bias in studies where confounder missingness depends on unobserved factors. Missing data Confounding EHR NLP Real-World Evidence ORIGINAL UNEDITED MANUSCRIPT High-dimensional multiple imputation (HDMI) for partially observed confounders including natural language...
Journal Article
Correction to: “Canonical causal diagrams to guide the treatment of missing data in epidemiologic studies”
Margarita Moreno-Betancur and others
American Journal of Epidemiology, Volume 194, Issue 3, March 2025, Pages 877–880, https://doi.org/10.1093/aje/kwae406
Published: 17 January 2025
... Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. causal inference directed acyclic graphs missing data missing at random missing not at random multiple...
Journal Article
Weighted Q-learning for optimal dynamic treatment regimes with nonignorable missing covariates
Jian Sun and others
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Biometrics
Biometrics, Volume 81, Issue 1, March 2025, ujae161, https://doi.org/10.1093/biomtc/ujae161
Published: 07 January 2025
..., it can lead to nonignorable missing pseudo-outcomes in the earlier stages. We provide a detailed illustration of this unique missing data problem with DTRs caused by backward-induction-induced nonignorable missing pseudo-outcomes in Section 2.3 . In this research, we aim to address the issue...
Journal Article
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Adjusting for Selection Bias Due to Missing Eligibility Criteria in Emulated Target Trials
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Luke Benz and others
American Journal of Epidemiology, kwae471, https://doi.org/10.1093/aje/kwae471
Published: 26 December 2024
... of bariatric surgery on microvascular outcomes among a cohort of severely obese patients with Type II diabetes mellitus (T2DM). Target trial emulation missing data selection bias electronic health records inverse probability weighting ORIGINAL UNEDITED MANUSCRIPT American Journal of Epidemiology Submitted...
Journal Article
Unlocking the power of multi-institutional data: Integrating and harmonizing genomic data across institutions
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Yuan Chen and others
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Biometrics
Biometrics, Volume 80, Issue 4, December 2024, ujae146, https://doi.org/10.1093/biomtc/ujae146
Published: 16 December 2024
... through extensive simulation studies. The extracted latent features from the Bridge model consistently excel in predicting patient survival across six cancer types in GENIE BPC data. cancer genomics data integration dimension reduction missing data precision oncology systematic biases NIH 10.13039...
Journal Article
BAMITA: Bayesian multiple imputation for tensor arrays
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Ziren Jiang and others
Biostatistics, Volume 26, Issue 1, 2025, kxae047, https://doi.org/10.1093/biostatistics/kxae047
Published: 14 December 2024
.... There is a growing literature on missing data imputation for tensors. However, existing methods give a point estimate for missing values without capturing uncertainty. We propose a multiple imputation approach for tensors in a flexible Bayesian framework, that yields realistic simulated values for missing entries...
Journal Article
Estimating marginal treatment effect in cluster randomized trials with multi-level missing outcomes
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Chia-Rui Chang and Rui Wang
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Biometrics
Biometrics, Volume 80, Issue 4, December 2024, ujae135, https://doi.org/10.1093/biomtc/ujae135
Published: 04 December 2024
... interest lies in the estimation of and inference about the parameters in the marginal mean model with link function , where targets the marginal treatment effect. When there is no missing data, an estimator of can be obtained by solving the following estimating equation (Liang and Zeger...
Journal Article
Recoverability of causal effects under presence of missing data: a longitudinal case study
Anastasiia Holovchak and others
Biostatistics, Volume 26, Issue 1, 2025, kxae044, https://doi.org/10.1093/biostatistics/kxae044
Published: 16 November 2024
... cited. Summary Missing data in multiple variables is a common issue. We investigate the applicability of the framework of graphical models for handling missing data to a complex longitudinal pharmacological study of children with HIV treated with an efavirenz-based regimen as part of the CHAPAS-3 trial...
Journal Article
Gentrius: Generating Trees Compatible With a Set of Unrooted Subtrees and its Application to Phylogenetic Terraces
Olga Chernomor and others
Molecular Biology and Evolution, Volume 41, Issue 11, November 2024, msae219, https://doi.org/10.1093/molbev/msae219
Published: 21 October 2024
...Olga Chernomor; Christiane Elgert; Arndt von Haeseler; Andrey Rzhetsky Table 1 Summary for biological datasets ID Species group Sp. Loci Missing data (%) Max locus coverage Sp. min coverage Stand size Total CPU time D1 Snails 62 1027 37 58 (94%) 0 1 2 s D2...
Journal Article
Sparse inference of the human haematopoietic system from heterogeneous and partially observed genomic data
Gianluca Sottile and others
Journal of the Royal Statistical Society Series C: Applied Statistics, Volume 74, Issue 1, January 2025, Pages 204–228, https://doi.org/10.1093/jrsssc/qlae052
Published: 14 October 2024
... haematopoietic system multiple Gaussian graphical models missing data University of Palermo 10.13039/501100004913 (FFR2022) and (FFR2023) Research Projects of National Relevance B53D23009480006 Research Projects of National Relevance C53D23002580006 Italian Ministry of University...
Journal Article
A stableness of resistance model for nonresponse adjustment with callback data
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Wang Miao and others
Journal of the Royal Statistical Society Series B: Statistical Methodology, Volume 87, Issue 2, April 2025, Pages 433–456, https://doi.org/10.1093/jrsssb/qkae097
Published: 14 October 2024
... estimation missing data paradata semiparametric efficiency National Key R&D Program of China 10.13039/501100012166 2022YFA1008100 National Natural Science Foundation of China 10.13039/501100001809 12292983 12071015 Ministry of Education, Singapore 10.13039/501100001459...
Journal Article
Seismic data interpolation with a recurrent inference mechanism
Huimin Sun and others
Journal of Geophysics and Engineering, Volume 21, Issue 6, December 2024, Pages 1636–1650, https://doi.org/10.1093/jge/gxae092
Published: 12 September 2024
.... Especially, the recovery of aliased and consecutively missing data is incredibly challenging. To solve this problem, we propose a novel framework for seismic interpolation using a recurrent inference mechanism (SIRIM). Integrating the advantages of supervised and unsupervised learning paradigms, we build...
Journal Article
Inference for extreme spatial temperature events in a changing climate with application to Ireland
Dáire Healy and others
Journal of the Royal Statistical Society Series C: Applied Statistics, Volume 74, Issue 2, March 2025, Pages 275–299, https://doi.org/10.1093/jrsssc/qlae047
Published: 04 September 2024
... the study domain, which is much larger than the change in mean temperature levels over this time window. We illustrate how these characteristics result in increased spatial coverage of the events that exceed critical temperatures. climate change extreme values heatwaves missing data nonstationarity...
Journal Article
Analyses using multiple imputation need to consider missing data in auxiliary variables
Paul Madley-Dowd and others
American Journal of Epidemiology, kwae306, https://doi.org/10.1093/aje/kwae306
Published: 27 August 2024
... variable did not have a large influence on the magnitude of bias reduction. Under missing outcome mechanism 3 (outcome missingness caused by the exposure only; Figure 2G-I ), no bias was observed when the auxiliary missingness data did not depend on any other variable (Plot G). When the auxiliary...
Journal Article
Software application profile: tpc and micd—R packages for causal discovery with incomplete cohort data
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Ryan M Andrews and others
International Journal of Epidemiology, Volume 53, Issue 5, October 2024, dyae113, https://doi.org/10.1093/ije/dyae113
Published: 26 August 2024
... packages are freely available on the Comprehensive R Archive Network (CRAN). Their source code is also available on GitHub ( https://github.com/bips-hb/micd ; https://github.com/bips-hb/tpc ). Causal discovery R cohort studies missing data longitudinal data National Institutes of Health 10.13039...
Journal Article
Balancing efficacy and computational burden: weighted mean, multiple imputation, and inverse probability weighting methods for item non-response in reliable scales
Andrew Guide and others
Journal of the American Medical Informatics Association, Volume 31, Issue 12, December 2024, Pages 2869–2879, https://doi.org/10.1093/jamia/ocae217
Published: 13 August 2024
... available responses, but potentially overlook missing data intricacies. Advanced methods like multiple imputation (MI) address broader missing data, but demand increased computational resources. Researchers frequently use survey data in the All of Us Research Program (All of Us...
Journal Article
A novel deep machine learning algorithm with dimensionality and size reduction approaches for feature elimination: thyroid cancer diagnoses with randomly missing data
Onder Tutsoy and Hilmi Erdem Sumbul
Briefings in Bioinformatics, Volume 25, Issue 4, July 2024, bbae344, https://doi.org/10.1093/bib/bbae344
Published: 15 July 2024
... for recognizing the benign and malignant cases. However, it can be a disadvantage as well, if the input data is not pre-processed properly before training the machine learning algorithms. Figure 4 presents the percentages of the missingness in the data. Figure 4 Missingness data percentages, a) from low, b...
Journal Article
Multimodal subtypes identified in Alzheimer’s Disease Neuroimaging Initiative participants by missing-data-enabled subtype and stage inference
Mar Estarellas and others
Brain Communications, Volume 6, Issue 4, 2024, fcae219, https://doi.org/10.1093/braincomms/fcae219
Published: 25 June 2024
... biomarkers derived from structural MRI. In this study, we adapted the Subtype and Stage Inference algorithm to handle missing data, enabling the application of Subtype and Stage Inference to multimodal data (magnetic resonance imaging, positron emission tomography, cerebrospinal fluid and cognitive tests...
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