.... We evaluated the expression of immunometabolism markers and matrix metalloproteinases (MMPs) in cells infected with M. bovis, and following HIF-1α inhibition in vitro. To understand the implications of HIF-1α inhibition on disease progression, mice at different infection stages were treated...

... Dendritic cells Immune tolerance Matrix metalloproteinases Signaling pathway β-catenin Nuclear factor kappa-B National Natural Science Foundation of China 10.13039/501100001809 81871583 Key R&D Program Projects of Zhejiang Province 2021C03072 Natural Science Foundation of Zhejiang...

...-like morphology. The key transcriptional regulators of EMT (SNAIL and ZEB1) and some EMT markers were upregulated at both RNA and protein levels in response to CDT/CdtB. CdtB increased the expression and proteolytic activity of matrix metalloproteinases, as well as cell migration. A range...

... due to CNS viral infection and conclude that the pathological accumulation of extracellular matrix components in the dentate gyrus and amygdala causes neuronal hyperexcitability and seizures by altering ionic homeostasis. matrix metalloproteinases minocycline hippocampus resting membrane potential...

... changes in altered mediators of airway tissue remodeling such as matrix metalloproteinases. Correspondence: Theodoros Kelesidis, MD, PhD, University of Texas Southwestern, 5323 Harry Hines Blvd, Room Y9.206, Dallas, TX 75390 ( [email protected] ). Potential conflicts of interest...

... of CTEPH development following an acute pulmonary embolism, several molecular studies have been carried out and reported [ 3 , 4 ]. Matrix metalloproteinases (MMPs) are an important group of proteins that play a crucial role in extracellular matrix (ECM) remodelling [ 5 ]. Due to the role of MMPs in ECM...

... in degradation of the neuromuscular junction (NMJ) and blocks neurotransmission between the pre- and postsynaptic structures, which are separated by a synaptic cleft. Matrix metalloproteinases (MMPs), enzymes that degrade and modify the extracellular matrix, play critical roles in regulating NMJ remodeling. We...

... of target compounds from various matrices using microwaves and solvents^{[ 10 ]}. pulmonary fibrosis exopolysaccharides matrix metalloproteinases Masson’s trichrome apoptosis Abstract Objectives The first goal of this study was to synthesize the silver nanoparticles Alcaligenes...

... : Central nervous system, MMPs : Matrix metalloproteinases, MSOD : Mitochondrial superoxide dismutase, PAI-1: Plasminogen activator inhibitor-1, PSH: Post stroke hyperglycaemia, ROS : Reactive oxygen species. pati Shams university Hospitals for 6 months and obtaining an Corresponding author: Dr_ayman81...

... RGD motif, upregulating matrix metalloproteinases and resulting in enhanced bacillary survival. 21 07 2020 31 01 2021 05 02 2021 29 04 2021 © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions...

... increased expression and activity of matrix-metalloproteinases (MMPs). We aimed to establish a novel adeno-associated virus (AAV)-based strategy for long-term expression of an AP-1 neutralizing RNA hairpin (hp) decoy oligonucleotide (dON) in the aorta to prevent aortic elastolysis in a murine model...

... procumbens extract on UV-B-induced matrix-metalloproteinase expression in human dermal fibroblasts . J Ethnopharmacol   2011 ; 137 : 427 – 433 . D'Orazio   J   et al.   UV radiation and the skin . Int J Mol Sci   2013 ; 14 : 12222 – 12248 . Liebel   F   et al.   Irradiation...

... in atherogenesis and cardiovascular diseases (CVD). Matrix metalloproteinases (MMPs) are genetically distinct but structurally related proteinases that can process almost all extracellular matrix components. Matrix degradation is also closely linked to the destructive inflammatory diseases. By decisive cleavages...

... of the brain has a pivotal role in the pathophysiology of major depressive disorder (MDD) and schizophrenia (SCZ). Matrix metalloproteinases (MMPs) are extracellular proteases involved in pro-inflammatory processes and interact with interleukin-6, which is increased in the cerebrospinal fluid (CSF) of patients...

... 211.39 20.1324 1323.7 22.6489 9297.37 13 926.6 5554.01 54.1057 SEGA19 13 639.8 14.6952 6709.02 585.136 343.333 0 538.378 50.7652 8770.36 21 080.9 4945.6 1068.74 MMPs, matrix metalloproteinases; SEGA, subependymal giant cell astrocytomas; TIMPs, tissue-inhibitors...

... have shown modest, short-term improvements in ejection fraction, but long-term cardiac remodelling is unabated. ^{9 , 10} Hence, a better adjuvant therapy is needed to prevent anthracycline cardiotoxicity. Matrix metalloproteinases (MMPs) are zinc-dependent proteases best...

... smooth muscle actin (α-SMA), Collagen I, III, matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9, respectively), tissue inhibitor of metalloproteinase 1 (TIMP-1), transforming growth factor-β1 (TGF-β1), phospho-Smad2 (p-Smad2), phospho-Smad3 (p-Smad3) and phospho-p38 (p-p38) were examined by Western...

.../standard_publication_model ) Abstract OBJECTIVES To summarize the present evidence for the association of matrix metalloproteinases (MMPs) with acute aortic dissection (AAD), we performed the first meta-analysis of all currently available case–control studies comparing circulating MMP levels between AAD patients...

... responsible for the reduction in mPDL-1 is unknown. Increased expression of matrix metalloproteinases (MMPs) has been reported in CD. Herein we observed that when compared to N- and ulcerative colitis (UC)-MFs, CD-MFs increase in LPS-inducible levels of MMP-7 and -9 with a significant increase in both basal...

..., a CD36 neutralizing antibody (CD36Ab) significantly inhibited macrophage phagocytic capacity. The combination of CXCL4 and CD36Ab did not have an additive effect, indicating that CXCL4 regulated phagocytosis through CD36 signalling. CXCL4 infusion significantly elevated infarct matrix metalloproteinase...