... than mood changes, changes in energy and motor activity are the vital symptoms in mania and depression. This multi-dimensionality and heterogeneity within the bipolar disorder spectrum pose significant challenges for understanding its illness course and making clinical decisions. Efforts to address...

... by a cluster of abnormal behaviors including hyperactivity, impulsivity, reduced despair/depression-like behavior, hypersensitivity to low dose of amphetamine, memory deficits, and decreased prepulse inhibition, which are reminiscent of mania. Furthermore, the hyperactivity of Sapap4 KO mice could...

.... bidirectional suicide register schizophrenia mania/epidemiology An important relationship between psychosis and self-harm has been recognised since the early 1900s, when Eugen Bleuler described the “suicidal drive” as the “most serious of all schizophrenic symptoms.”  ¹ Since that time, dozens...

..., career at the Birmingham and Midland Hospital for Women, Barker was committed to Holloway Sanatorium in Virginia Water with a diagnosis of ‘Chronic Mania’. Barker’s story sheds new light on the pressures placed on early women doctors to succeed, as well as the troubled internal dynamics...

... is not available, on expert opinion. The literature suggests that depression rather than mania is the most challenging phase ( Manning, 2005 ). If subsyndromal, the presence of residual symptoms impose a greater risk of relapse ( Keller et al., 1992 ), greater disability, and poorer overall outcome ( Tohen et al...

...-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Abstract Background Several currently available animal models reproduce select behavioral facets of human mania as well...

.../funder_policies/chorus/standard_publication_model ) Abstract Background Brain structural and functional changes in bipolar disorder (BD) are well-established findings, but it is uncertain whether these changes are already present in first episode mania (FEM). Methods We compared 31 FEM subjects, with 31...

... fashion and displayed antimanic efficacy in a behavioral assay of mania. casein glycomacropeptide branched-chain amino acids dopamine depletion serotonin depletion tyrosine depletion tryptophan depletion mania Significance Statement Casein glycomacropeptide (CGMP) is a peptide that lacks...

... and positive) in close others; and that symptoms lasted for a duration of “2–3 days” or more. This was chosen because the DSM 4-day threshold excludes many individuals with bipolar disorder II ²³ and fits the ICD-10 requirement for hypomania to have lasted for a “few days.” cannabis mania...

... report on the psychometric properties of the 16-item Concise Associated Symptom Tracking Scale self-report scale and its clinical utility. Methods The 5-domain (irritability, anxiety, mania, insomnia, and panic) structure of Concise Associated Symptom Tracking Scale was validated with confirmatory...

... impairment is not a clinical mark of mania, it is important to emphasize that bipolar patients show cognitive damage ( Rolstad et al., 2016 ) and prefrontal alterations ( Blumberg et al., 1999 ) compared with healthy control groups. Amodeo and colleagues (2017) demonstrated that ouabain induces cognitive...

.../mania diffusion tensor imaging reward processing nucleus accumbens amygdala medial orbitofrontal cortex Bipolar disorder is associated with significant work impairment, high rates of divorce and substance abuse, a 10-year earlier mortality rate, and elevated suicidality ( Angst et al...

... not permit such a unified approach. bipolar disorder anticonvulsants antidepressants antipsychotics evidence-based guidelines lithium mania bipolar depression mood stabilizers treatment clinical trials All members of the workgroup made formal declarations of interest that are included at the end...

... ). The first study investigating the efficacy of lithium against acute mania was conducted in 1971, but it did not follow a methodology that is accepted today as scientific standard ( Stokes et al., 1971 ). Since then 4 placebo-controlled RCTs using modern clinical trial methodology starting in 1994 have been...

... the word “lypemania.” Finally, Jean-Pierre Falret (1794–1870) and Jules Gabriel Francois Baillarger (1809–1890) established the connection between depression and mania and gave it the name of “folie circulaire” or “folie à double forme,” but it was Emil Kraepelin (1856–1926) who established manic...

... of lack of knowledge where further focused research is necessary. BD anticonvulsants antidepressants antipsychotics evidence-based guidelines lithium mania bipolar depression mood stabilizers treatment The first 3 papers of the International College of Neuropsychopharmacology (CINP) guidelines...

..., was evident in FEBP. Similar to chronic patients, cognitive functions in FEBP lie intermediate between FES and healthy controls. Neurodevelopmental factors are likely to play a significant role not only in schizophrenia but also in BP. bipolar disorder cognition/mania psychosis schizophrenia In contrast...

... with the Hamilton Depression Rating Scale, 17-item version ( Hamilton, 1967 ), and the Young Mania Rating Scale ( Young et al, 1978 ) to characterize the severity of depressive and manic symptoms, respectively. The healthy control group was recruited from the local population and participants did not have...

...-order goals. The findings extend a functional neuroanatomical account of disorders characterized by clinically impulsive decision-making, and provide targets for evaluating interventions that foster self-control. bipolar disorder mania reward striatum accumbens risk Impulsive and risky decision...

... species are classified into the four subgenera supported by our phylogenetic study. nomenclature systematics tulip mania typification Come tiptoe through the tulips with me (A. Dubin, 1929 ) Tulipa L. (Liliaceae) is a genus of bulbous monocots with, depending on the author, 50–60 (Van...