... group. Furthermore, hypoxia-inducible factor (HIF) 1 mRNA and protein expression were decreased, indicating reoxygenation in this group. In conclusion, SQAP improved hypoxic conditions in tumor tissue and may elicit a radiosensitizing effect in malignant mesothelioma models. malignant pleural...

... play a key role in immunological-cell-mediated arterial remodelling. In this study, we clarified the role of macrophage-derived hypoxia-inducible factor (HIF-1α) in vascular remodelling. Methods and results Wire-induced femoral arterial injury was inflicted in mice lacking the macrophage-specific...

... in the cloned LO promoter. Treatment of rat lung fibroblasts (RFL6) with CoCl₂ (Co, 10–100 μM), a chemical hypoxia reagent, enhanced LO mRNA expression and promoter activities. Overexpression of LO was associated with upregulation of hypoxia-inducible factor (HIF)-1α at mRNA levels in cobalt (Co...

... by viability studies. After dexmedetomidine treatment, p-AKT, hypoxia-inducible factor (HIF)-1α, vascular endothelial growth factor (VEGF) and RTP801 expression were measured. Key findings Three hours of OGD decreased cell viability to 48.8%, which was reversed to 67.4% by 1 µm...

... as Tie2 in leptomeningeal SWS blood vessels. Intriguingly, these factors are known to be transcriptionally induced by hypoxia-inducible factor (HIF). The HIF system has emerged as the key regulatory system of responses to hypoxia. Immunohistochemical analysis demonstrated markedly elevated nuclear HIF-1α...

... Preconditioning Hypoxia-inducible factor (HIF) Ischemic injury to the myocardium due to the spectrum of coronary occlusion events known as acute coronary syndromes account for a large proportion of all hospital admissions and of all causes of death in western society. Despite several recent successful advances...

... of these tumors; specifically within those patients with this genetic disorder. autosomal dominant Von Hippel-Lindau hemangioblastomas retinal hemangioblastomas pheochromocytomas VHL tumor suppressor gene hypoxia inducible factor (HIF) VEGF (vascular endothelial growth factor) Familial central nervous...