... ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract We report the discovery of a short, large amplitude X-ray flare from AT2019vcb (aka Tormund), a tidal disruption event...

... genome duplication (WGD) events generate potent new genomic resources for rewiring existing genetic regulatory networks. Studying WGDs in vertebrates is of considerable importance to understand vertebrate evolution. Recent studies have shown that different invertebrate lineages, including...

..., provided the original work is properly cited. ABSTRACT Many studies employ the analysis of time-to-event data that incorporates competing risks and right censoring. Most methods and software packages are geared towards analyzing data that comes from a continuous failure time distribution. However, failure...

... benefits of interventions and public health and programmatic messaging tailored to older adults living with frailty. respiratory syncytial virus respiratory syncytial virus infection influenza frailty older adults major clinical events outcomes ACCEPTED MANUSCRIPT Open Forum Infectious Diseases MAJOR...

... to improve the prediction of severe TRT in this vulnerable population. prediction models geriatric assessment adverse events chemotherapy cancer geriatric oncology systematic review older people This systematic review analysed 12 studies involving 90,819 participants, identifying 15 prediction models...

..., provided the original work is properly cited. Abstract Objectives Home-based phototherapy (HP) has gained traction as an alternative to hospital-based treatment for neonatal hyperbilirubinemia, but the safety of this practice remains unclear. This study aimed to identify adverse events (AEs) associated...

... of sudden cardiac death (SCD). Implantable cardioverter-defibrillators (ICDs) are critical for SCD prevention, but risk stratification remains challenging. Objective To evaluate the predictive performance of conventional risk factors for arrhythmic events in HCM patients with ICDs. Methods We...

... heat stress, with generalizations in the European policy context. stochastic frontier analysis technical efficiency production risk heat stress dairy farming weather events Farmers globally are facing an increasing number of challenges, including extreme weather events due to the ongoing climate...

... , 28 , 29 , 47 , 50 ] of tocilizumab reported SAEs. All studies involved hospitalized patients; reporting periods ranged from 5 to 90 days. Risk of bias was low in 5 studies; the rest had a moderate or unclear risk of bias. Table 1. Serious Adverse Events in Studies of Tocilizumab...

... the TriNetX database. Exposures included treatment with finerenone, SGLT2i or a combination of both. The primary outcome was major adverse kidney events (MAKE). Secondary outcomes included all-cause mortality, major adverse cardiac events (MACE) and end-stage renal disease (ESRD). Results A total of 853...

... rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. opioids opioid use disorder methadone buprenorphine adverse events National...

... [email protected]. Accepted Manuscript Abstract Background and Aims: Climate change, particularly the increased frequency of extreme climatic events, poses significant challenges to the biodiversity and functionality of semi-natural grasslands. However, the response of plant functional traits of grassland...

.... Methods This prospective 2-center observational study enrolled children with confirmed or suspected gram-positive CNSIs. Clinical outcomes and adverse events were compared between linezolid-treated patients and a matched vancomycin cohort. Population pharmacokinetic (PopPK) modeling with nonlinear mixed...

..., Systematic Coronary Risk Evaluation (SCORE)2, Predicting Risk of cardiovascular disease EVENTs (PREVENT)-cardiovascular disease (CVD) and PREVENT-atherosclerotic cardiovascular disease (ASCVD) equations in predicting cardiovascular (CV) risk among individuals with chronic inflammatory rheumatic diseases...

... care (BSC) versus placebo plus BSC. Here we report detailed safety data from FRESCO-2 including an analysis of treatment-related adverse events of special interest (AESIs). Patients and methods Patients with mCRC eligible for FRESCO-2 had received all standard chemotherapies and prior anti-VEGF...

... switching from TDF- to TAF-based regimens, with no impact on obesity or metabolic clinical events [ 15 ]. In addition, the TANGO trial [ 16 ] reinforced the idea that the adverse metabolic effects of TAF might be absent, as it revealed that switching from TAF-containing regimens to DTG + 3TC led to weight...

... emitters (ECLEs) are a rare class of galaxy that exhibit strong, high-ionization iron coronal emission lines in their spectra. In some cases, these lines are transient and may be the result of tidal disruption event (TDEs). To test this connection, we calculate the rate of variable ECLEs (vECLEs...

..., patients 0 to 18 years at KD diagnosis, minimum follow-up >1 year, and ≥10 patients included. Of 5072 articles, 181 were included. Cardiovascular events and mortality were extracted and pooled for analysis. Meta-analyses and meta-regression analyses were performed. The primary outcome of interest...

... foundational role in shaping Chinese civilization. early Zhou epic sacrifice culture war culture family relationship map events map the Book of Songs Abstract The aim of this article is to discuss the characteristics of the culture of the Zhou Dynasty of China and try to find out some...

...-rights ) Abstract Background In 2010, the World Health Organization (WHO) increased the recommended doses of first-line tuberculosis (TB) drugs for children. In this systematic review, we aimed to determine the proportion of children who developed adverse events (AEs) on first-line TB treatment...