... via the Permissions link on the article page on our site–for further information please contact [email protected]. Abstract Gestation is a vulnerable window when exposure to per- and polyfluoroalkyl substances (PFAS) may impact child development and health. Epigenetic modification...

... pathogenesis and identifying potential therapeutic targets. Brain-specific epigenetics Alzheimer’s disease risk DNA methylation biomarkers Mendelian randomization Gene expression regulation University of Hawai'i Cancer Center Alzheimer’s disease (ad) is a devastating neurodegenerative disorder...

... improved performance in identifying cell-type-specific differential methylation CpGs. DNA methylation cell-type-specific differential CpGs bulk tissue epigenetics EWAS National Institute for Occupational Safety and Health 10.13039/100000125 National Institute of Aging U01OH012466...

... epigenetic changes, although the exact mechanisms remained unclear ( Shen et al., 2016 ; Ramakrishnan et al., 2022 ). However, the interplay of redox regulation with DNA methylation, histone methylation and deacetylation, and miRNA biogenesis has been reported ( Auverlot et al...

... for all genes, which were correlated with transcript level abundances. Differences in the occupancy of the profiled epigenetic marks between sexes were associated with differential gene expression between males and females. Finally, we found a significant enrichment of the permissive H4K16ac histone mark...

... into nucleosomes independently of DNA replication. Nucleosomes with canonical histones or histone variants can have differential epigenetic impact ( Henikoff and Smith 2015 ). Posttranslational modifications to the histone tails can occur at any point and help to regulate the chromatin structure and impact gene...

... variation for crop breeding, however the lethality of epigenetic mutants in crop species has hindered its investigation. Here, we exploit partial redundancy between homoeologues in polyploid wheat to generate viable mutants in the DNA methyltransferase 1-1 (MET1-1) gene with altered...

... and potential targeted therapeutic strategies for POI. In this review, we summarize the epidemiological characteristics of POI, as well as progress in genetic and epigenetic etiologies, and discuss advances in pharmacology and material science that will likely contribute to new interventions for ovarian aging...

[email protected] 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract In recent years, the study of bovine sperm epigenetics has garnered increasing...

...Anna-Lee C Thompson; Judith L M Wopereis; Yonas I Tekle; Laura A Katz Fig. 1. Graphical representation of microscopy techniques with applications to visualize epigenetic targets. Bolded and enlarged techniques are discussed in this review. Super-resolution methods can be adapted from widefield...

... permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Epigenetic silencing is essential for regulating gene expression and cellular diversity in eukaryotes. While DNA...

... residual promoter-proximal TF function in ATRT. Graphical abstract Graphical Abstract ATRT rhabdoid tumor epigenetics chromatin transcription factors Accepted Manuscript SWI/SNF complexes govern ontology-specific transcription factor function in MYC-subtype atypical teratoid rhabdoid tumor Cody L...

... change the DNA sequence of an organism. This powerful technology now fuels basic biology discovery and tangible crop improvement efforts. There is a less well understood layer of information encoded in genomes, known collectively as ‘epigenetics’, that impacts gene expression, without changing the DNA...

... and facial anomalies (ICF) syndrome inborn errors of immunity mass cytometry ZBTB24 epigenetics Accepted Manuscript In-depth immune profiling of a patient with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2 caused by a novel mutation in ZBTB24. Colleen M Roark1,2, Diana...

... hypothesis suggests that epigenetic adaptations occur in fetal DNA as a response to environmental influences. The review also emphasizes the role of the mechanism associated with possible epigenetic effects in the placenta, mediating the effects of maternal stress on the fetus, impacting gene expression...

... mechanism that depends on the generation of small RNA molecules that leads to the degradation of the targeted messenger RNAs (mRNAs). Nuclear RNAi is a unique process that triggers regulation through epigenetic alterations to the genome. This pathway has been extensively characterized in Caenorhabditis...

...René S Shahmohamadloo; John M Fryxell; Seth M Rudman; Henrique Teotonio; Jason Wolf Figure 1. A schematic diagram illustrates the experimental design testing transgenerational epigenetic inheritance (TEI) in Daphnia magna. Eight genotypes were initially reared on either a Chlorella-only...

... these epigenetic changes provide an adaptative advantage remains unclear. Here, we provide evidence that DNAme is required to regulate thermomorphogenesis in Arabidopsis. Hypomethylated drm1 drm2 cmt3 mutants and seedlings treated with 5-azacytidine to block DNAme exhibited reduced hypocotyl growth...

...-reuse-rights ) Abstract Study Objectives To investigate associations between adolescent sleep duration and timing, and blood leukocyte DNA methylation, one type of epigenetic modification that may respond to changes in sleep. Methods Cross-sectional epigenome-wide analysis of DNA methylation...

..., integrated gene annotation, and quantitative trait locus information. Furthermore, various “Explore” and “Browse” functions have been established for user-friendly access to omics information. PIGOME implemented several tools to visualize genomic variants, gene expression, and epigenetic signals of a given...