... stable to proteolytic processing by caspase-3; truncation is evidenced by the TauC-3 antibody. The entorhinal cortex showed high sensitivity to neurodegeneration and pathological tau processing. In Alzheimer's disease, pathological tau processing is characterized by post-translational changes...

... preceding dementia that would facilitate the development of preventative and therapeutic interventions for Alzheimer’s disease. To this end, we developed a 3D virtual reality task sensitive to the activity of grid cells in the entorhinal cortex, which is the region that first exhibits neurofibrillary...

... [email protected] Abstract Functional magnetic resonance imaging faces inherent challenges when applied to deep-brain areas in rodents, e.g. entorhinal cortex, due to the signal loss near the ear cavities induced by susceptibility artifacts and reduced sensitivity induced by the long distance from...

... II entorhinal cortex (ERC) cell clusters ( Hyman et al. 1986 ; Braak and Braak 1991 , 1992 ; Braak and Del Trecidi 2015 ; Braak and Del Tredici 2015 ; Kaufman et al. 2018 ). Tau pathology can be seen initiating in these neurons even in young adults, with tangles appearing even in middle age...

.../ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Recent models of Alzheimer’s disease suggest the nucleus basalis of Meynert (NbM) as an early origin of structural degeneration followed by the entorhinal cortex (EC...

... object-location memory paradigm to assess the effect of Levodopa, a dopamine precursor, on grid-like activity in the entorhinal cortex. We found that Levodopa impaired grid cell-like representations in a sample of young adults (n = 55, age = 26–35 years) in a novel environment, accompanied...

... for the initiation and propagation of synaptic dysfunction along the entorhinal–hippocampal circuit. Here, using chronic EEG recordings, we show that a single injection of extracellular vesicles carrying β-amyloid into the mouse entorhinal cortex could trigger alterations in the cortical and hippocampal activity...

... into three tissue classes: gray matter, white matter, and cerebrospinal fluid, then summed to obtain the total brain volume. Graphical Abstract Graphical Abstract aging dementia neurodegenerative disorders chronotype entorhinal cortex temporal lobe cognitive decline memory impairment cohort study...

... in rodents suggest that gradients of temporal dynamics in the hippocampus and entorhinal cortex support this integration. In humans, gradients of representation are observed, such that granularity of information represented increases along the long axis of the hippocampus. The neural underpinnings...

... neural processes serving reward frequency versus magnitude maximization that can have clinical translational utility to optimize decision-making. reward expected value melioration memory entorhinal cortex orbitofrontal cortex National Institutes of Health 10.13039/100000002 University...

... entorhinal cortex observed in a matched control group. Impairments in spatial and relational cognition associated with schizophrenia may thus arise from disrupted grid firing patterns in entorhinal cortex. schizophrenia entorhinal cortex grid cells spatial memory Leverhulme Doctoral Training Programme...

...Chu-Chung Huang; Edmund T Rolls; Chih-Chin Heather Hsu; Jianfeng Feng; Ching-Po Lin Key questions we asked in humans were as follows. Is the hippocampal system mainly hierarchical, with the entorhinal cortex a gateway to and from the hippocampus, and direct connections mainly between each...

... (DHA, including lysophosphatidylcholine DHA) and APOE ε4 genotyping. Relative regional brain volumes were calculated and linear regression models were fitted to examine DHA associations with brain volume. APOE genotype modulated serum DHA associations with entorhinal cortex volume...

... of AD markers in the memory-associated entorhinal cortex (ERC) of seven SuperAgers compared with six age-matched cognitively average normal control individuals. Amyloid plaques and NFTs were visualized using Thioflavin-S histofluorescence, 6E10, and PHF-1 immunohistochemistry. Unbiased stereological...

... of entorhinal and neocortical degeneration, calling into question a prevailing view of Alzheimer’s disease pathogenesis. Alzheimer’s disease basal forebrain NbM entorhinal cortex nucleus basalis of Meynert Alzheimer’s disease neuropathology progresses in stages, with certain brain regions affected...

... showed that this induction requires input from the entorhinal cortex. Somatic SP colocalized with α-Actinin2, a known binding partner of SP. Finally, ultrastructural analysis revealed SP immunoprecipitate on dense plates linking cytoplasmic and perinuclear ER cisterns; these structures were absent...

... been implicated in the pathophysiology of human temporal lobe epilepsy (TLE). The different nuclei of this complex structure are interconnected and share reciprocal connections with the hippocampus and other brain structures, partly via the entorhinal cortex. Expression of GABA_A receptor...

... ) for a scientific commentary on this article. Entorhinal cortex is affected early in Alzheimer’s disease and is critical for navigation. Using immersive virtual reality, Howett et al. reveal navigational deficits in biomarker-positive patients with mild cognitive impairment. Navigational deficits are more...

... for second derivative and smoothed with a triangular kernel of length 3 ( Freeman and Nicholson 1975 ). The entorhinal cortex (EC) and hippocampus are critically involved in spatial navigation and learning and memory ( Buzsaki and Moser 2013 ; Moser et al. 2015 ). The EC receives and processes information...

...Ryota Sakurai; Robert Bartha; Manuel Montero-Odasso Figure 1. Coronal T₁-weighted magnetic resonance imaging after skull stripping in one participant showing example masks of the segmented hippocampus (yellow), parahippocampal gyrus (light blue), and entorhinal cortex (pink). Full...