... in schizophrenia and other neuropsychiatric disorders. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative in the early 2000s marked a pivotal moment for drug development, establishing consensus on methodology for treatment studies, including assessment strategies...

... This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Cognitive Impairment Associated with Schizophrenia study design enrichment methodology drug development...

... narcolepsy. histamine narcolepsy cataplexy drug development Abstracts CINP2024 digital devices or online as a kind of phenotype and is attracting attention as a means of future medical care, but there are not many cases applied to insomnia.(Kim et al., 2023, Lee et al., 2023) Aims & Objectives: Therefore...

... and mechanism of RS-D7 on the alleviation of MSA. Taking advantage of in vitro assays, in vivo efficacy tests, and proof- of-concept clinical trials in drug development, a series of experiments was conducted on RS-D7 in this study. Method In Experiment 1, enzymatic inhibition and cell-based inhibition assay...

... with the smallest difference | e i − e r i | . We then computed a Kaplan-Meier survival curve using the outcome data of the matched patients. National Cancer Institute 10.13039/100000054 5P30CA077598-23 clinical trials drug development external control arms...

... in specific POI-PROTAC-E3 interactions, thus offering invaluable insights and guidance for future pharmaceutical research. Availability and implementation The codes of our model are available at https://github.com/GuanyuYue/ET-PROTACs drug development PROTAC drug–target interaction cross modal deep...

... investments were concentrated in several therapeutic areas, including cancer. biopharmaceutical industry prescription drug policy investment in research and development drug development Arnold Ventures 10.13039/100014848 Recent public policies have raised concerns about their potential adverse impact...

... Summary Analyzing data from 17 IBD clinical trials with over 16 000 screened patients, we found a screen failure (SF) proportion of 44% for UC and 51% for CD. The primary cause of SF was inadequate clinical and/or endoscopic activity scores. IBD clinical trials drug development screen failure Key...

... and transmissibility, and antiviral natural products development of JEV. JEV bioactive natural products antiviral drug development Health Research Project of Shaanxi Province 2022D040 Shaanxi Provincial Education Department 10.13039/501100009103 22JK0545 Natural Science Basic Research Program...

... and translating these findings into practical medical applications. COVID-19 drug development medicinal plants molecular docking natural compounds phytoconstituents SARS-CoV-2 therapeutic modalities The new coronavirus SARS-CoV-2 that produced the coronavirus disease 2019 (COVID-19) pandemic has created...

..., and strategies to enhance drug development. antimicrobial drugs gonorrhea drug development antimicrobial resistance unmet need Center for Drug Evaluation and Research 10.13039/100022416 US FDA 10.13039/100000038 CARB-X 10.13039/100019590 US Department of Health and Human Services...

...Yue Li; Bingyan Liu; Jinyan Deng; Yi Guo; Hongbo Du Table 2 Several public databases used for drug development. Here we provide the name, brief description, url and references of these databases, aiming at facilitating related research Database name Description URL References...

... peptides have gained wide attention in the field of drug development. Cyclic peptides have shown prospects in the domains of anticancer, antibacterial, and antiviral drug discovery [ 8 ]. In anticancer research, cyclic peptide drugs play a pivotal role in impeding tumor growth and angiogenesis by actively...

... and implement methods that catalyze the translation of genomics knowledge into therapeutic advancements. The complexity and prevalence of B.C. therapeutics and clinical drug development are improved by applying genomic technology. At a time when personalized medicine is gaining relevance and healthcare costs...

... the need to expand biomarker profiling in combination with CTCs stratification for improved biomarker-driven drug development. Table 1. Descriptive analysis of the 644 patients eligible for the KNN analysis. All baseline features were equally balanced among pStage IV_aggressive and pStage...

... diseases drug development To address challenges with the development of inhaled antifungal therapies, the US Food and Drug Administration convened a workshop on 25 September 2020 to discuss clinical trial designs for both prophylaxis and treatment and strategies to streamline product development. Abstract...

..., Neovasc, Nobel Pharma, Horizon, International Drug Development Institute (IDDI), SVB Leerink, Medtronic, Regeneron, Wake Forest University, Recor, Janssen, and IDDI; payments from lectures from Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks...

... is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Seizure liability remains a significant cause of attrition throughout drug development. Advances in stem cell biology...

... approaches to this disease. This article reviews the literature on the medical management of high-risk localized and advanced GIST and provides an update on clinical trial approaches to this disease. sarcomas cancer diagnostics and molecular pathology new drug development and clinical pharmacology...

.... Regarding advances in drug development for the treatment of MM, differences in drug availability and accessibility in China and the rest of the world exist due to varying drug developmental stages and therapy types. The most widely used drug combinations are almost similar in China and other countries...