... the original work is properly cited. Abstract Identification of intrinsically disordered regions (IDRs) in proteins is essential for understanding fundamental cellular processes. The IDRs can be divided into long disordered regions (LDRs) and short disordered regions (SDRs) according to their lengths...

... Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Intrinsically disordered arginine-glycine (RG) repeat domains are enriched in multilayered biomolecular condensates such as the nucleolus. Caenorhabditis elegans nucleolar RG repeats are dispensable...

... in developing every step of OSA care will be necessary to eliminate racial disparities ultimately. health disparities race sleep-disordered breathing oximetry CPAP tonsillectomy National Institutes of Health 10.13039/100000002 HL082610 Over the past 40 years, care pathways for obstructive sleep apnea...

... that intelligent use of disorder in metamaterials leads to distributed damage during failure, resulting in enhanced fracture toughness with minimal losses of strength. Toughness depends on the level of disorder, not a specific geometry, and the confined lattices studied exhibit a maximum toughness enhancement...

... the autosomal recessive disorder Bloom Syndrome, characterized by predisposition to numerous types of cancer. Prior studies of Drosophila Blm mutants lacking helicase activity or protein have shown sensitivity to DNA damaging agents, defects in repairing DNA double-strand breaks (DSBs), female...

..., disorder [IDR], IEP, and coiled-coil region similarity) were filtered, finalists were analyzed to examine their structural organization. As described above, proteins with confirmed coiled-coil domains were put in a graphical overlay that combined coiled-coil and IDR prediction on a per-residue basis...

..., provided the original work is properly cited. Abstract The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide...

... These authors contributed equally to this work. Graphical Abstract Figure. This study delves into the regulation of phase separation in intrinsically disordered proteins (IDPs) by ATP and identified IDP conformational compaction a mechanism...

...Patrícia Jost; Ana Lurdes Conte; Adriana de Oliveira Lira; Fernando Pugliese; Juan Martin Palomo; Beatriz Quevedo; Daniela Garib CAPES – ‘Coordination for the Improvement of Higher Education Personnel’ Sleep-disordered breathing (SDB) describes upper airway (UA) dysfunction during sleep...

... for sensitivity analyses. A recording of a minimum duration of 4 hours, free of significant artifacts, was required for inclusion. obstructive sleep apnea sleep-disordered breathing white matter hyperintensities cerebral small vessel disease aging Statement of Significance Obstructive sleep apnea (OSA...

... assessing demographics and emotion regulation difficulties (Difficulties in Emotional Regulation Scale), inhibitory control (go/no-go task, food and general stimuli), working memory (N-Back Task, food and general stimuli), binge eating (Binge Eating Scale), and disordered eating (Eating Disorder...

... Personalized treatment options for OSA should take into consideration age and sex. Reducing loop gain could be a treatment objective for older patients with OSA. Graphical Abstract Graphical Abstract arousal threshold collapsibility older personalized medicine sleep disordered breathing women young...

...Jae Won Choi; Dae Lim Koo; Dong Hyun Kim; Hyunwoo Nam; Ji Hyun Lee; Seung-No Hong; Baekhyun Kim Graphical Abstract Graphical Abstract OSA machine learning sleep-disordered breathing radar deep learning Korea Medical Device Development Fund 10.13039/100019266 Corresponding author. Dong Hyun...

... condition in women and is associated with significant reproductive, metabolic, and psychological comorbidities ( 1 , 2 ). The associations between PCOS and mental health disorders, such as depression and anxiety, have been clearly established in multiple systematic reviews and meta-analyses ( 3...

... with intrinsically disordered regions (IDRs) ( Goh et al. 2015 ; Monette et al. 2020 , 2022 ; Beckwith et al. 2023 ; Kaddis Maldonado et al. 2023 ). These regions do not adopt a stable 3D structure but rather exist in a collection of structurally distinct conformers known as an ensemble ( Holehouse and Kragelund...

... TFs, focusing on the jasmonate (JA) and ethylene (ET) signaling pathways, with the key TFs MYC2/3/4 and EIN3/EIL1. This study revealed that JAZ10^CMID, the binding domain of the repressor involved in the desensitization of both TFs, is an intrinsically disordered region in the absence...

[email protected]. 2024 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract While bulimia nervosa (BN) and binge eating disorder (BED) are prevalent in military...

...-sensitivity C-reactive protein (hs-CRP) in adolescents/young adults with SDB. Sleep-disordered breathing (SDB) encompasses a range of clinical and subclinical conditions characterized by snoring and/or recurrent episodes of upper airway obstruction during sleep. It is known to be an independent risk factor...

... 2024 15 04 2024 Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2024. 2024 This work is written by (a) US Government employee(s) and is in the public domain in the US. Abstract Binge eating disorder (BED) is a public health concern that has...

... hypoventilation is characterized by increased alveolar partial pressure of carbon dioxide (PaCO2), leading to hypercapnia and acid-base disorders. The body compensates for these changes chronically by varying bicarbonate levels. Reduction in minute ventilation is a common feature of all chronic hypoventilation...