... of genetic MCT8 deficiency, a major cause of X-linked intellectual disability. thyroxine tri-iodothyronine cretinism myelination hypothyroidism European Research Council 10.13039/501100000781 2019-WATCH-810331 Deutsche Forschungsgemeinschaft 10.13039/501100001659 MU-3743/1-1 CRC/TR296...

... fortification iodine iodine deficiency goiter cretinism Food fortification is a public health strategy that is widely implemented to prevent and control micronutrient deficiencies. Iodine deficiency is one of the most common micronutrient deficiencies and, as of 2015, approximately 2 billion people were...

... is the condition of endemic cretinism, described from the Middle Ages and characterized in its fully developed form by severe brain damage, deaf mutism and a spastic state of the hands and feet. The demonstration of the prevention of cretinism in a double-blind controlled trial with injections of iodized oil...

... supplementation of infants may reduce infant mortality in populations at risk for iodine deficiency. infants mortality iodine deficiency goiter cretinism This study suggests that there may be a possible differential effect of treatment according to gender. Nutritional and immunological differences between...

..., Beltsville, MD 20705. glutathione peroxidase Keshan disease thyroxine goiter cretinism RDA Workshop: New Approaches, Endpoints and Paradigms for RDAs of Mineral Elements Deliberations...

...: experts who have the scientific knowledge and tech nological know-how, food producers and marketers cretinism intellectual impairment who are able to create demand and deliver improved iodine deficiency public health thyroid hormone...

... intracellular GSH peroxidase activity, selenium deficiency may increase hydrogen peroxide (H₂O₂) supply and lead over several weeks to the thyroid atrophy observed in myxoedematous cretins. By improving thyroid hormone synthesis and by decreasing peripheral thyroxin (T₄...

... for several decades. The evidence is also strong that iodine supplementation is effective in preventing both varieties of endemic cretinism, provided it is given before conception; early fetal and infant death may also be prevented. However, the reason for the variation in prevalence of the different types...

... protein-energy malnutrition. However, specific nutrients have crucial roles. Iodine deficiency is the most important and widespread nutrient deficiency; it causes endemic cretinism, associated with deaf-mutism and cerebral palsy. Iodine deficiency during pregnancy causes both maternal and fetal...

... Ubangi, mean serum TSH for a given serum T₄ was approximately twice as high for children aged < 15 y than for those aged 16–25 y. The high frequency of myxedematous cretins observed in Ubangi very probably result from both severe iodine and selenium deficiency together with thiocyanate...

... T Diplock, and Jacques E Du,nont ABSTRACT Studies were performed to assess the role of Guinea-neurological cretinism is more common than is myx- combined selenium and iodine deficiency in the etiology of en- edematous cretinism (6). demic...

... in embryonic tissues demic cretin. Am J C/in Nuir Suppl 1993;57:280S-5S. before onset of fetal thyroid function and if so, KEY WORDS Thyroxine, 3.5,3’-triiodothyronine, cretin- are they of maternal...

... effect on neuroblast multiplication and, if so, this many millions living in a system of subsistence agri could be important in the pathogenesis of the neurological culture in Latin America, Asia, and Africa, iodine de form of endemic cretinism. The assessment of the full ficiency will persist...

..., they support the possibility that correction of iodine deficiency may improve mental performance in school age children, particularly girls. Endemic goiter cretinism iodine deficiency intelligence testing iodized oil thyroid The effects of oral iodized oil...

... congenital hypothyroidism, and in severe form, the irreversible brain damage associated with cretinism. Moderate iodine deficiency in pregnancy is associated with lower learning capacity, reduced IQ, hearing impairment, and increased risk of attention deficit disorder. Pregnant women should take a daily...

... and selenium. TH deficiency during development causes intellectual disability. Extreme lack of iodine, and hence lack of TH, causes a particularly severe form known as cretinism. However, even mild iodine deficiency during pregnancy can have a detrimental effect on the child's cognitive development...

... rapidly reverse the neurologic symptoms. Thyroid disease thyroxine hypothyroidism thyrotoxicosis muscle loss depressed consciousness myxedema coma thyroid stimulating hormone (TSH) congenital hypothyroidism cretinism intellectual disability cerebellar ataxia tremor choreoathetosis Autoimmune...

... discovered in the village of Willendorf, Austria in 1908 C.E.), with various forms of morbid obesity, and others, such as the Starving Buddha (a 2nd century B.C.E. bronze statue located in the Lahore Museum), that depict Kwashiorkor, cretinism, scurvy, pellagra, and other ravages...

.... Treatment of these latter etiologies requires administration of thyroid hormone. cretinism hypothyroidism congenital iodine deficiency thyroid hormone synthesis intellectual disability brain thyroid hormone rectorswe Congenital hypothyroidism Cretinism Hypothyroidism congenital Intellectual...