... therapies ^17-20 The corticobasal syndrome (CBS) is characterized by a progressive asymmetric akinetic-rigid syndrome and cortical features including apraxia, cortical sensory loss and cognitive dysfunction. ¹ Although CBS was first described in individuals with corticobasal degeneration...

... manifestations of apraxia in a cohort of corticobasal syndrome patients (CBS) by use of cortical thickness. Twenty-six CBS patients were included in this cross-sectional study. The Goldenberg apraxia test (GAT) was applied. 3D-T1-weighted images were analyzed via the automated recon-all Freesurfer version 6.0...

... agreement. ³⁵ From a pathological perspective, large autopsy-proven studies have shown that patients presenting with both AOS and agrammatism, PPAOS and PAA are typically associated with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). ¹¹ But, less...

... differs according to the background pathology. Hence, detecting CBD pathology in CBS is extremely challenging. Corticobasal degeneration (CBD) is a rare neurodegenerative disorder characterized by neuronal loss and the predominance of hyperphosphorylated 4-repeat (4R) tau deposition in various brain...

.... Figure 1 Sankey plot of change in diagnosis between baseline ⁸ and study end point. 4RT = four-repeat tau; AD = Alzheimer’s disease; CBS = corticobasal syndrome; IDT = indeterminate; MSA-C = multiple system atrophy cerebellar variant; MSA-P = multiple system atrophy parkinsonian variant...

..., Lewy Body disease neuropathologic change, as well as chronic microvascular lesions, hippocampal sclerosis of aging, and cerebral amyloid angiopathy. In this study, the Condensed Protocol is updated to include frontotemporal lobar degeneration [FTLD] tau (corticobasal degeneration, progressive...

.../standard_publication_model ) Abstract 3R/4R-tau species are found in Alzheimer disease (AD) and ∼50% of Lewy body dementias at autopsy (LBD+tau); 4R-tau accumulations are found in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Digital image analysis techniques can elucidate patterns of tau...

... consecutively autopsied cases with progressive supranuclear palsy (n = 26), corticobasal degeneration (n = 12), globular glial tauopathy (n = 5), Alzheimer’s disease (n = 21) or Pick's disease (n = 6) and neurologically healthy controls (n = 36). Ten...

... Oyama; Kensuke Okada; Masahito Kubota; Hajime Okita; Masaki Takao; Masahiro Jinzaki; Jin Nakahara; Masaru Mimura; Daisuke Ito Tau imaging Alzheimer’s disease tauopathy progressive supranuclear palsy corticobasal degeneration One patient (#52) with PSP-CBS underwent PET scan with [¹⁸F]PM...

...) FIGURE 1. Schematic summary of training the model. Training and validation are performed using 1500 images of tau lesions. Images with a wide range of color, size, and morphology are annotated in each tau lesion. An image from a patient with corticobasal degeneration is predicted as an astrocytic...

... as a corticobasal syndrome. We sought to relate retention of the tau-PET tracer ¹⁸F-AV-1451 and structural magnetic resonance measures of regional atrophy to clinical features in clinically diagnosed and neuropathologically confirmed cases of corticobasal syndrome and to determine whether these vary...

[email protected] Abstract Mounting evidence suggests an association between cerebellar atrophy and cognitive impairment in the main frontotemporal dementia syndromes. In contrast, whether cerebellar atrophy is present in the motor syndromes associated with frontotemporal lobar degeneration (corticobasal syndrome...

... dementia (bvFTD) ( Rascovsky et al., 2011 ), primary progressive aphasia [with the non-fluent (nfvPPA) and semantic (svPPA) subtypes] ( Gorno-Tempini et al., 2011 ), progressive supranuclear palsy (PSP) ( Höglinger et al., 2017 ) or corticobasal syndrome (CBS) ( Armstrong et...

... motion. Our sample was drawn from a cohort of 69 healthy controls, and patients with idiopathic Parkinson’s disease (n = 35), progressive supranuclear palsy Richardson’s syndrome (n = 52) and corticobasal syndrome (n = 36). Participants underwent standardized T1-weighted...

... University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Abstract Distinct neuronal and glial tau pathologies define corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). Additional...

... in vivo volumetric and intrinsic connectivity imaging measures and post-mortem measures of neurodegeneration and tau inclusion burden. We assessed these relationships across brain regions and within individuals in patients with pathological diagnoses of progressive supranuclear palsy (PSP) or corticobasal...

... and corticobasal degeneration. The evidence base from in vivo and post-mortem human studies, and preclinical models, suggests new strategies to facilitate the development of symptomatic pharmacological treatments, in stratified populations. 5 7 2017 5 9 2017 3 10...

...) are critical for regulating homeostasis, behavior, and cognition. RF degenerates in tauopathies including Alzheimer disease (AD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Although the burden of phopho-tau inclusion is high across these diseases, suggesting a similar...

... 0,2,2,0 GOIs - WM + + ++ ++ − ++ ++ +++ +++ ++ 0,4,0,0 0,2,2,0 4,0,0,0 0,2,1,1 CBD = corticobasal degeneration; GAIs = globular astrocytic inclusions; GM = grey matter; GOIs = globular oligodendroglial inclusions; PiD = Picks disease; WM = white matter. Severity...

... sclerosis who lacked neurodegenerative disease-related pathology outside of the motor system. Patients with FTLD were distributed between FTLD-tau (34 patients: 10 corticobasal degeneration, nine progressive supranuclear palsy, eight Pick’s disease, three frontotemporal dementia with parkinsonism associated...