... responses among participants without cerebrospinal fluid (CSF) determined amyloid pathology (A-; cognitively normal [CN], n=83) and those with amyloid pathology (A+, n=202), further stratified into preclinical (CN with A+, n=72) and mild cognitive impairment (MCI with A+, n=130). Participants were drawn...

... an autoimmune process targeting the hypothalamic hypocretin-producing neurons. Aiming to add clues to the latter hypothesis, we investigated circulating cell-free mitochondrial DNA (ccf-mtDNA) levels in cerebrospinal fluid (CSF), a possible biomarker for neurodegeneration, neuroinflammation or immune activation...

... and the limited sensitivity of conventional diagnostic tests. Although serum (1→3)-β-d-glucan (BDG) and galactomannan (GM) assays are FDA-approved for the diagnosis of invasive fungal infections (IFIs), their effectiveness in cerebrospinal fluid (CSF) remains underexplored, and optimal cutoff values...

... publications have addressed the influence or predictability of cognitive performance. This led us to perform retrospective data analysis to find prognostic biomarkers with a focus on correlation with cognitive performance. We looked at neurodegeneration markers from cerebrospinal fluid, including neurofilament...

... cysts and compared to cerebrospinal fluid (CSF) reference ranges. Data are shown as mean values for each cyst type (n = 2 glioependymal, n = 2 arachnoid). P-values were calculated using an unpaired t-test. There were no statistically significant differences between...

... with DCI onset. Methods Twelve aSAH patients were enrolled. Leukocyte populations and cytokine levels were analyzed in cerebrospinal fluid (CSF) and peripheral blood (PB) on days 3, 5, 7, 10, and 14 post-aSAH. Peripheral blood mononuclear cells (PBMCs) were collected and their cytokine production...

... Abstract intracranial pressure cerebrospinal fluid pressure hydrocephalus head position body position National Brain Appeal 10.13039/100015873 Brain health depends critically on the regulation of intracranial pressure (ICP). ICP reflects the force exerted within the skull by the volumes of the brain...

... system lymphoma (CNSL), is a rare subtype of non-Hodgkin lymphoma, primarily affecting the brain and spinal cord. Most therapeutic systemic agents have limited penetration of the blood-brain and blood-cerebrospinal fluid barrier, with the latter potentially promoting a treatment sanctuary for cancer...

... the various components of cerebrospinal fluid dynamics. The results underline important caveats for its use in patients with acute brain injury wherein the estimated values differ from the measured ones. Overall, additional metrics describing the cerebrovascular system or the underlying disease have...

... cerebrospinal fluid without the involvement of neural tissue. Neurosurgical intervention is necessary in the newborn period since survival in advancing ages is often impossible. Therefore, meningoceles are rarely reported in adulthood. Here, we discussed a case of a 23-year-old female who presented...

... of these factors for humans is unclear. We examined five previously identified brain rejuvenation factors in cerebrospinal fluid of adults with autosomal dominant forms of frontotemporal dementia and sporadic Alzheimer’s disease. Our frontotemporal dementia cohort included 100 observationally followed adults...

... system injuries, and mixed parenchymal and non-parenchymal disease. p-NBD is pathologically characterized by perivasculitis presenting with cerebrospinal fluid (CSF) pleocytosis, elevated total protein, and central nervous system (CNS) infiltration of macrophages and neutrophils, which are subdivided...

... Key Points There are substantial differences in the glioma cerebrospinal fluid (CSF) proteome across anatomical sites. Resection has a significant temporal impact on the glioma CSF proteome. Longitudinal CSF can be acquired for early pharmacodynamic evaluation of systemic therapies...

...-hydroxyglutarate (D-2-HG) levels in cerebrospinal fluid (CSF). Panel A: Paired comparisons of D-2-HG levels between lumbar and intracranial CSF samples from IDH-mutant gliomas (n = 14 pairs) with a significant increase in intracranial levels (P = .0001). Panel B: Paired comparisons between lumbar and intracranial...

... arterial line. Distal injections—microspheres injected into the distal (distal perfusion) arterial line. CBP: cardiopulmonary bypass; CSF: cerebrospinal fluid; CSF ×3: increase of cerebrospinal fluid pressure to ×3 from the baseline; DP: distal perfusion; IQR: interquartile range; SD: standard deviation...

... helps regulate the brain’s glymphatic system, and that heart failure can disrupt glymphatic system homeostasis. See Harrison ( https://doi.org/10.1093/brain/awaf054 ) for a scientific commentary on this article. cerebrospinal fluid cardiovascular disease cerebral blood flow Swedish Research Council...

[email protected] Dear Editor, Chronic pain in spinal muscle atrophy (SMA) is common. ¹ Mechanistic studies are lacking, hampering the development of mechanism-specific treatments. This exploratory study examined the association of the metabolic profile of the cerebrospinal fluid (CSF) of patients...

... that biological characteristics such as age and sex have on cortisol levels across compartments is also limited. Objective To assess the relationships of cortisol levels across cerebrospinal fluid (CSF), saliva, and plasma (total and free) compartments and describe the effects of age and sex...

...⁺ T cells in ALS. Graphical Abstract Graphical Abstract amyotrophic lateral sclerosis cerebrospinal fluid single-cell RNA sequencing T-cell receptor clonality Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the brain and spinal...

... of the neural cell niche or in the presence of cerebrospinal fluid and under various spatial conditions (microprinting). The neuroprotective properties of DFATs were assessed using the coculture method with the ischemically damaged nerve tissue. Graphical Abstract Graphical Abstract DFATs micropatterning...