... cited. Abstract Background Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory deficit and has emerged as a growing global health concern. Phosphodiesterase-8 (PDE8) is a cAMP-specific hydrolase and its correlation with AD pathogenesis remains underexplored. Here...

... intolerance in SA/SA male mice. lipid droplets cAMP dependent kinase peroxisome proliferator-activated receptor alpha insulin receptor substrate 2 ACCEPTED MANUSCRIPT 1 Transcriptional response to fasting studied in the liver of mice that express phosphorylation 2 resistant perilipin 5 3 Corinne E Bovee 1...

... in the infection. Furthermore, we identified pulmonary nonimmune cells as an important source of increased CRAMP levels as the infection progressed and CRAMP production drove mortality. These insights emphasize the age-specific role of CRAMP in influenza viral pathogenesis. anti-microbial peptide CRAMP/CAMP...

... University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Context In 2023, we employed Dexcom G6 for real-time continuous glucose monitoring (rt-CGM); it showed high usefulness but unsatisfactory accuracy in summer camp (camp...

... in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract The spatiotemporal interplay between the second messenger cyclic AMP (cAMP) and its main effector, protein kinase A (PKA), is crucial for the pleiotropic nature...

... adenosine monophosphate (cAMP) contributes to CB and sympathetic responses to CIH. Our findings show that CIH increases cAMP levels in the CB, a response absent in Adcy3, Cth (encoding CSE), and Olfr78 null mice. CBs from Cth and Olfr78 mutant mice lacked a persulfidation...

... for ADORA_2A and ADORA_2B was assessed, and messenger RNA (mRNA) analysis was performed. Cyclic ADO monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) were quantified both in rat vagina smooth muscle cells (rvSMCs) and in vaginal tissues with increasing doses of ADO. Outcomes...

...Aristides Hadjinicolaou; Mylène Dandavino; David D’Arienzo; Kimberley Kaspy; Elisa Ruano Cea Boot-camp Boot camp Curriculums Programs Resident Residency Transition Residency training includes several critical clinical transition...

... Magmatic Province and the Deccan Traps with rock samples location. The preserved volume of the CAMP (map adapted from Marzoli et al., 2018 ) is volumetrically dominated by intrusive rocks, whereas the preserved volume of the Deccan (map adapted from Marzoli et al., 2022...

... within the broader economic context of persistent and fluctuating resource demands. Nor did employment and livelihood activities provide a linear pathway to self-reliance, as refugee households faced economic backslides due to shocks. In refugee camp contexts, where residents often remain excluded from...

... exclusively in female mice, which may be associated with cAMP-PKA/Epac2 pathway. Our study findings underscore the therapeutic potential of targeting PDE7A as a promising treatment modality for alcohol use disorder, aiming to facilitate translational research for gender-specific clinical interventions...

.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Members of the phosphodiesterase 4 (PDE4) enzyme family regulate the availability of the secondary messenger cyclic adenosine monophosphate (cAMP...

.../standard-publication-reuse-rights ) Abstract Background This study was designed to assess stress levels and related factors during the coronavirus disease 2019 (COVID-19) epidemic among individuals in centralized quarantine camps in Wenzhou, China. Methods The survey was conducted using...

.... Furthermore, the protein kinase A (cAMP-dependent protein kinase) inhibitor H89 completely attenuated fustin-induced downregulation of phosphorylated myosin phosphatase targeting subunit 1, which is involved in dephosphorylation of MLC2. In a mouse model, administration of fustin suppressed tumor growth...

...Elizabeth Robinson-Self Abstract German-language concentration camp poetry has been frequently criticized for its formal failings, particularly its lack of innovation and overreliance on traditional forms. In this article, I undertake close readings of three formally conventional texts: Alfred...

... of TRPV1 to capsaicin but diminished that to eugenol. OR51E2 also showed similar effects. Based on the susceptibility to the OR's modulatory effects, various TRPV1 ligands could be classified into capsaicin and eugenol types. Activation of OR51E1 enhanced cAMP production. In addition, forskolin exhibited...

... showed an increased population in G₁/G₀ phase. Among four CI mutants, ndh51Δ/Δ and goa1Δ/Δ displayed aberrant cell cycle patterns correlated with previously reported cAMP/PKA downregulation. Specifically, nuo1Δ/Δ and nuo2Δ/Δ mutants exhibited...

... is an integral part of a cell-intrinsic pathway that couples cell density information with prosurvival signalling thereby regulating the appropriate number of peripheral T cells. coronin T cells cell population size regulation T cell homeostasis immunodeficiency cAMP-Ca²⁺ signalling T cells...

...-specific flocculation (Matsuzawa et al.   2013 ). Current understanding of the glucose-sensing cAMP-PKA pathway is illustrated in Figure  2 . This pathway has mostly been elucidated by the Hoffman group (Byrne and Hoffman 1993 ; Hoffman 2005 ). The glucose signal is mainly transferred through...

... G_i/o class G proteins. Dibutyryl cyclic-AMP, sodium salt (10 μm; Tocris Bioscience, MN, USA) was applied as exogenous cAMP. Dopamine (10 μm; Tocris Bioscience, MN, USA) was used to stimulate D₂-like DA receptors for the activation of G_i/o class G proteins...