... blood-brain barrier National Institutes of Health 10.13039/100000002 R24OD031447 R24OD022005 Laminins are large molecular-weight glycoproteins that are major components of the extracellular matrix in the basement membrane [ 1 ]. The basic unit of laminins are heterotrimers that consist of three...

... H9c2 cells. Haematoxylin and eosin and Masson staining were performed to observe morphological differentiation and fibrosis in myocardial tissues. Evans blue staining was used to analyse blood–brain barrier (BBB) permeability. Behavioural experiments were conducted to assess the learning and cognitive...

... or in combination with other chemotherapeutic agents [ 7 ]. The mechanisms underlying CRCI are still not well defined, and the kidney function of such patients has not been reported. However, mechanisms of CRCI include direct neurotoxicity through disruption of the blood–brain barrier (BBB), decreased neuronal...

... cited. Abstract Blood–brain barrier peptides (BBBP) could significantly improve the delivery of drugs to the brain, paving the way for new treatments for central nervous system (CNS) disorders. The primary challenge in treating CNS disorders lies in the difficulty pharmaceutical agent’s face...

...Stuart A Grossman; Carlos G Romo; Xiaobu Ye; Brian Kral; Roy E Strowd; Glenn Lesser; Catalina Raymond; Michaella Iacoboni; Serena Desideri; Joy Fisher; Neeraja Danda; Benjamin M Ellingson Abstract Background The blood-brain barrier (BBB) severely limits the delivery of therapeutic agents...

... the history of GBS perinatal disease and its clinical presentation and treatment, as well as patient outcomes. We then present recently discovered GBS interactions at the blood–brain barrier that contribute to disease and inflammatory responses, and efforts to develop a broadly effective GBS vaccine. blood...

... significantly larger coverage volumes. However, in a follow-up analysis of individuals with a gross total resection who were in the CED arm, catheter positioning scores did not significantly impact PFS or OS. ⁵⁰ Table 3. Clinical Trials using Convection-Enhanced Delivery for Blood–Brain Barrier...

... system injuries, and mixed parenchymal and non-parenchymal disease. We summarized opinions on the clinical diagnosis, biomarkers, and pathological findings of NBD. Graphical Abstract Graphical Abstract neuro-Behçet’s disease biomarkers cerebrospinal fluid diagnosis blood–brain barrier...

.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Hypoxia triggers blood–brain barrier disruption and a strong microglial activation response around leaky cerebral blood vessels. These events...

... Brain metastasis remains an unmet clinical need in advanced cancers with an increasing incidence and poor prognosis. The limited response to various treatments is mainly derived from the presence of the substantive barrier, blood–brain barrier (BBB) and brain–tumour barrier (BTB), which hinders...

... drainage. The mechanisms underlying enlargement of perivascular spaces are not fully understood, but both increased inflammation and blood–brain barrier (BBB) permeability have been hypothesized to play a role. We investigated the relationship between perivascular spaces and both CNS and peripheral...

.../pages/standard-publication-reuse-rights ) Abstract Background and Hypothesis Angiogenesis triggered by inflammation increases BBB permeability and facilitates macrophage transmigration. In the midbrain, we have discovered molecular alterations related to the blood-brain barrier (BBB), including...

..., additional kidney-specific risk factors may contribute, such as uremic toxins, electrolyte imbalances, chronic inflammation, acid–base disorders or endocrine dysregulation. Traditional and kidney-specific risk factors may interact to cause damage to the blood–brain barrier, induce vascular damage...

... and in vivo assays using patient-derived DMG cultures to elucidate the mechanism of action of Napabucasin and its radiosensitizing properties. As penetration of systemic therapy through the blood-brain barrier (BBB) is a significant limitation to the success of DMG therapies, we explore focused ultrasound...

... bacterial components across the blood-brain barrier, initiating the physiologic changes involved in Alzheimer disease. In this review, we summarize recent data that support the relationship between vesicles secreted by periodontal pathogens to Alzheimer disease pathology. bacterial vesicles periodontitis...

..., systemic administration of this antibody lowered brain levels of complement activation products, and reduced neurodegeneration, synapse loss, and amyloid burden. neuroinflammation therapy drug delivery blood–brain barrier mouse model Alzheimer’s disease (AD) is the most prevalent neurodegenerative...

... This work is written by (a) US Government employee(s) and is in the public domain in the US. See the journal About page for additional terms. Abstract The blood-brain barrier (BBB) is an extensive capillary network that protects the brain from environmental and metabolic toxins while limiting drug delivery...

... is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Chronic hyperglycemia can result in damage to the hippocampus and dysfunction of the blood-brain barrier (BBB...

... and evaluated factors influencing NVU damage severity and timing of NVU effects resulting from ionizing radiation. Results Seventy-two rodents, 4 canines, 1 rabbit, and 5 human studies met inclusion criteria. Radiation increased blood-brain barrier (BBB) permeability, reduced endothelial cell number...

... unprovoked C-start escape responses) than their sibling controls. Live imaging of Ca²⁺ signaling revealed prolongued, strong signals sweeping through the brain, indicative of neuronal hyperactivity. While the resulting tadpole brain appeared grossly normal, the blood-brain barrier (BBB) was found...