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Keywords: antiretroviral therapy
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Cardiovascular Hazards of Abacavir- Versus Tenofovir-Containing Antiretroviral Therapies: Insights From an Analysis of the REPRIEVE Trial Cohort
Emma Davies Smith and others
Open Forum Infectious Diseases, Volume 12, Issue 4, April 2025, ofaf177, https://doi.org/10.1093/ofid/ofaf177
Published: 21 March 2025
...) at entry. Overlap weights balanced biasing factors, including age, sex at birth, atherosclerotic cardiovascular disease risk, CD4 count, estimated glomerular filtration rate, and anchor antiretroviral therapy. Associations between entry NRTI and MACEs were estimated using a marginal Cox proportional...
Journal Article
Preswitch Regimens Associated With Weight Gain Among Persons With HIV who Switch to Integrase Inhibitor–Containing Regimens
Melissa Klein Cutshaw and others
Open Forum Infectious Diseases, Volume 12, Issue 3, March 2025, ofae752, https://doi.org/10.1093/ofid/ofae752
Published: 21 March 2025
...) is well documented. However, recent reports suggest that the observed weight gain among persons who switch to INSTIs may be associated with their preswitch regimen. Methods We conducted retrospective analyses of persons with HIV on antiretroviral therapy who switched to a second-generation INSTI...
Journal Article
Ethical issues surrounding the implementation of long-acting injectable antiretroviral therapy in sub-Saharan Africa
Deborah Ekusai-Sebatta and others
International Health, ihaf016, https://doi.org/10.1093/inthealth/ihaf016
Published: 13 March 2025
..., necessitating careful consideration of autonomy, access and equity, stigma, discrimination, sustainability and treatment adherence. cabotegravir ethics HIV injectable antiretroviral therapy rilpivirine sub-Saharan Africa National Institutes of Health 10.13039/100000002 P30A1027763 BO-1122 BO-0423...
Journal Article
Low levels of pertussis- and measles-specific IgG antibodies in 6-week-old HIV-exposed and -unexposed Malawian infants: implications for vaccination strategies and role of long term HIV therapy
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Silvia Baroncelli and others
Journal of Tropical Pediatrics, Volume 71, Issue 2, April 2025, fmaf013, https://doi.org/10.1093/tropej/fmaf013
Published: 10 March 2025
... highly prevalent, with more than 90% of children exposed in utero to HIV residing in these regions [ 16 ]. Globally, more than 81% of women living with HIV receive antiretroviral therapy (ART) during their pregnancy. However, their HIV-exposed uninfected (HEU) infants show immunological alterations...
Journal Article
Enhancing Hepatitis B Virus Vaccine Uptake and Immunity Through Long-Acting Antiretroviral Therapy Programmatic Synergy in the US South
Eudiah Ochieng and others
Open Forum Infectious Diseases, Volume 12, Issue 3, March 2025, ofaf096, https://doi.org/10.1093/ofid/ofaf096
Published: 19 February 2025
..., follow-up sAb+ Abbreviations: ART, antiretroviral therapy; cAb, core antibody; CAB/RPV, cabotegravir/rilpivirine; HBV, hepatitis B virus; sAb, surface antibody; sAg, surface antigen; vax, vaccination. aClassification at long-acting injectable ART initiation. Only...
Journal Article
Bone health in women living with HIV in Sub-Saharan Africa: antiretroviral therapy, lactation, and menopause
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Florence Nabwire
Journal of Bone and Mineral Research, Volume 40, Issue 4, April 2025, Pages 449–450, https://doi.org/10.1093/jbmr/zjaf015
Published: 05 February 2025
...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) African women bone health HIV lactation tenofovir-based antiretroviral therapy (ART) menopause In this issue of JBMR, Ó Breasail et al. 1 report substantial bone deficits in the peripheral skeleton among 40-60 yr old Zimbabwean women...
Journal Article
State-level variation in access to long-acting injectable antiretroviral therapy for HIV in the United States
Lauren C Zalla and others
Health Affairs Scholar, Volume 3, Issue 2, February 2025, qxaf016, https://doi.org/10.1093/haschl/qxaf016
Published: 29 January 2025
... injectable antiretroviral therapy (LAI-ART) is expected to improve health outcomes among persons with HIV. Yet, uptake has been slow and data on potential barriers to access are sparse. We used medication formulary data from state Medicaid and AIDS Drug Assistance Programs (ADAPs) to examine state-level...
Journal Article
EDITOR'S CHOICE
Predictors of Clinical Outcomes Among People With Human Immunodeficiency Virus and Tuberculosis Symptoms After Rapid Treatment Initiation in Haiti
Aaron Richterman and others
Open Forum Infectious Diseases, Volume 12, Issue 2, February 2025, ofaf031, https://doi.org/10.1093/ofid/ofaf031
Published: 20 January 2025
... predictors of clinical outcomes among people with human immunodeficiency virus (HIV) starting antiretroviral therapy (ART) in the modern era of rapid ART initiation. Methods We conducted a secondary analysis of a previously reported open-label randomized controlled trial of 2 rapid treatment initiation...
Journal Article
Real-world Rollout of Injectable Antiretrovirals for HIV Prevention and Treatment: Correlates of Early Adoption
Liza Koshy and others
Open Forum Infectious Diseases, Volume 12, Issue 2, February 2025, ofaf029, https://doi.org/10.1093/ofid/ofaf029
Published: 20 January 2025
... in real-world clinical settings. We characterized “early adopters” of injectable ART and PrEP in terms of social determinants of health. antiretroviral therapy HIV implementation long-acting injectable PrEP Long-acting injectable (LAI) antiretrovirals for HIV treatment (ART) and prevention (PrEP...
Journal Article
EDITOR'S CHOICE
Recent Antiretroviral Therapy Initiation Is Associated With Increased Mortality Risk in Human Immunodeficiency Virus–associated Cryptococcal Meningitis: An Analysis of Clinical Trial Data From Africa
Melanie Moyo and others
Clinical Infectious Diseases, ciae586, https://doi.org/10.1093/cid/ciae586
Published: 15 January 2025
... Therapy Induction Optimisation; ART, antiretroviral therapy; CFU, colony forming units; CSF, cerebrospinal fluid; 5FC, flucytosine; IQR, interquartile range. aThe AMBITION trial included 844 participants, 814 of whom were included in the intention to treat analysis after late exclusions...
Journal Article
Virologic Failure and Emergent Integrase Strand Transfer Inhibitor Drug Resistance With Long-Acting Cabotegravir for HIV Treatment: A Meta-analysis
Andrea Perez Navarro and others
Clinical Infectious Diseases, ciae631, https://doi.org/10.1093/cid/ciae631
Published: 26 December 2024
... cabotegravir integrase strand trasfer inhibitors drug resistance antiretroviral therapy Abstract Background The long-acting injectable regimen of cabotegravir plus rilpivirine (CAB/RPV) emerged as an alternative to oral standard-of-care integrase strand transfer inhibitor (INSTI)–based regimens...
Journal Article
EDITOR'S CHOICE
Patterns and Cofactors of Polyfunctional Mycobacteria-Specific T-Cell Response Restoration Following 6-Month Antiretroviral Treatment in Children With HIV
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Cheryl L Day and others
The Journal of Infectious Diseases, Volume 231, Issue 4, 15 April 2025, Pages 957–966, https://doi.org/10.1093/infdis/jiae630
Published: 18 December 2024
... antiretroviral therapy in children with HIV. These findings may explain persistent TB risk during early antiretroviral therapy among children with HIV. antiretroviral therapy CD4 T cell HIV immune reconstitution tuberculosis National Institute of Allergy and Infectious Diseases 10.13039/100000060...
Journal Article
Outcomes of HIV-infected children on antiretroviral therapy for at least 10 years at the Essos Hospital Centre, Cameroon: contributing to the elimination of paediatric AIDS in tropical settings
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Anne Esther Njom Nlend and others
Journal of Tropical Pediatrics, Volume 71, Issue 1, February 2025, fmae052, https://doi.org/10.1093/tropej/fmae052
Published: 13 December 2024
... <15 years versus 74% for those aged 15 and above [ 2 ]. HIV antiretroviral therapy long-term outcomes children Cameroon Abstract Evidence on long-term outcomes of children receiving antiretroviral therapy (ART) in low- and middle-income countries (LMICs) is of utmost importance to optimize...
Journal Article
Toward Evidence-based Recommendations for Laboratory Monitoring for Adolescents and Adults on Antiretroviral Therapy
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William J Burman and Kellie L Hawkins
Clinical Infectious Diseases, ciae542, https://doi.org/10.1093/cid/ciae542
Published: 10 December 2024
... prominent national and international guidelines to compare recommendations for laboratory monitoring for persons on antiretroviral therapy. The United States Department of Health and Human Services guidelines recommend more frequent CD4 count, viral load, hematologic, renal, and liver tests than other...
Journal Article
Efficacy and Safety of Switching to Daily Bictegravir Plus Lenacapavir From a Complex HIV Treatment Regimen: A Randomized, Open-Label, Multicenter Phase 2 Study (ARTISTRY-1)
Karam Mounzer and others
Clinical Infectious Diseases, Volume 80, Issue 4, 15 April 2025, Pages 881–888, https://doi.org/10.1093/cid/ciae522
Published: 26 November 2024
... page on our site—for further information please contact [email protected]. Abstract Background Complex antiretroviral therapy (ART) regimens, such as those requiring multiple tablets, several doses per day, or both, can negatively affect quality of life and treatment adherence among...
Journal Article
Effect of Micronutrients on HIV-Related Clinical Outcomes Among Adults Living With HIV on Antiretroviral Therapy: Systematic Review and Meta-analysis
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Elile Monisola Okoka and others
Nutrition Reviews, nuae171, https://doi.org/10.1093/nutrit/nuae171
Published: 22 November 2024
...) globally, with consequences for their health and clinical outcomes. Previous reviews of the influence of micronutrient supplementation on HIV outcomes were conducted in the pre–highly active antiretroviral therapy (pre-HAART) era or included both HAART-naive and HAART-experienced individuals; thus...
Journal Article
Human Immunodeficiency Virus 1 Low-Level Viremia Predicts Viral Failure in Participants on Antiretroviral Therapy in the Swiss HIV Cohort Study
Caroline Lanz and others
Clinical Infectious Diseases, ciae569, https://doi.org/10.1093/cid/ciae569
Published: 21 November 2024
... was met for all covariables. The introduction of combination antiretroviral therapy (ART) in the mid-1990s greatly reduced morbidity and mortality rates associated with human immunodeficiency virus (HIV) type 1 viral infection [ 1 ]. Plasma viral loads become undetectable in most people with HIV (PWH...
Journal Article
Rates and determinants of COVID-19 vaccine uptake among people living with HIV in Federal Capital Territory, Nigeria
Victoria Peter Etuk and others
Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 119, Issue 3, March 2025, Pages 210–220, https://doi.org/10.1093/trstmh/trae094
Published: 19 November 2024
... immunodeficiency virus (PLHIV) in Federal Capital Territory (FCT), Nigeria. Methods This was a cross-sectional study among PLHIV attending antiretroviral therapy clinics in FCT, Nigeria. We utilized an interviewer-administered, semi-structured questionnaire to collect data on COVID-19 vaccine uptake. Vaccine...
Journal Article
Determinants of antiretroviral therapy adherence among people living with HIV in a poor urban setting in Ghana: a hospital-based cross-sectional study
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Evelyn Adjei-Mensah and others
Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 119, Issue 2, February 2025, Pages 135–144, https://doi.org/10.1093/trstmh/trae091
Published: 06 November 2024
..., antiretroviral therapy (ART) continues to be the primary mode of managing HIV, transforming it from a formerly lethal disease to a less severe one. Adherence to ART can be impacted by several factors, including poor quality of care. Methods A quantitative cross-sectional study design was used to assess...
Journal Article
Impact of Dolutegravir Plus Lamivudine as First-line Antiretroviral Treatment on the Human Immunodeficiency Virus Type 1 Reservoir and Inflammatory Markers in Peripheral Blood
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Lucía Bailón and others
The Journal of Infectious Diseases, Volume 231, Issue 3, 15 March 2025, Pages 600–610, https://doi.org/10.1093/infdis/jiae530
Published: 28 October 2024
... is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background To compare the effects of first-line antiretroviral therapy (ART) with dolutegravir plus lamivudine (DTG...
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