...Sabrina M Wölfel; Catherine N Widmann; Sergio Castro-Gomez; Patrick Weydt; Pawel Tacik; Michael T Heneka The treatment of amyotrophic lateral sclerosis consists mainly of symptomatic management of distressing symptoms. In addition, riluzole and edavarone have been shown to have a disease-delaying...

..., please email: [email protected] 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Amyotrophic Lateral Sclerosis (ALS...

... in population biobanks. In this study, we aimed to identify proteins related to Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and amyotrophic lateral sclerosis by leveraging large-scale genetic and proteomic data. We performed a two-sample cis Mendelian randomization study by selecting...

... role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer’ s. Expert Opin Ther Targets, 25(5), pp. 401-414. amyotrophic lateral sclerosis sigma-1 receptor fluvoxamine Abstracts CINP2024 In contrast, bath application of retigabine (5 & micro;M), a Kv7 channel...

... degradation of lipids, malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine (8-OHdG). ¹³ Both MDA and 8-OHdG are oxidative stress markers, with some suggestive evidence that these markers are increased in people living with amyotrophic lateral sclerosis. ¹⁷ Given the emerging evidence...

..., distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Spinal muscular atrophy and amyotrophic lateral sclerosis are devastating neurodegenerative diseases characterized by motor neuron loss. Although these 2 disorders have distinct genetic origins, recent studies...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease, with most sporadic cases lacking clear genetic causes. Abnormal pre-mRNA splicing is a fundamental mechanism in neurodegenerative diseases. For example, TAR DNA-binding protein...

... the original work is properly cited. Abstract Nerve conduction F-wave studies contain crucial information about subclinical motor dysfunction that can be used to diagnose patients with amyotrophic lateral sclerosis (ALS). However, F-wave responses are highly variable in morphology, making waveform...

... Neuroinflammation impacts on the progression of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. Specialized pro-resolving mediators trigger the resolution of inflammation. We investigate the specialized pro-resolving mediator blood profile and their receptors’ expression in peripheral blood...

...Sara Simão; Lucas L Naumann; Mamede de Carvalho; Miguel Oliveira Santos; Isabel Pavão Martins European Union's Horizon 2020 GA101017598 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with heterogenous presentations ranging from pure motor manifestations to frontotemporal...

... signalling and impaired neuromuscular junction formation. Overexpressing C21ORF2 in mutant motor neurons restores ciliary function, suggesting a potential avenue for intervention. ALS C21ORF2 CFAP410 motor neuron disease primary cilia amyotrophic lateral sclerosis KU Leuven 10.13039...

..., distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, which still lacks effective disease-modifying therapies. Similar to other neurodegenerative disorders, such as Alzheimer...

... expanded CD8⁺  GZMK^high T cells in the CSF of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that these cells share expanded clones with those in the blood and co-localize with motor neurons, suggesting a pathogenic role for cytotoxic CD8...

...Khaled Atef Elsyed Allam; Nagia Ali Fahmy; Mohamed Amir Tork; Hebatallah Reda Rashed Abstract Background Amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig’s disease, is a neurodegenerative disease of the upper and lower motor neurons, resulting in muscular atrophy...

..., and reproduction in any medium, provided the original work is properly cited. Abstract Amyotrophic lateral sclerosis, a progressive neurodegenerative disease, presents challenges in predicting individual disease trajectories due to its heterogeneous nature. This study explores the application of texture analysis...

... are a major pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), which are two neurodegenerative diseases believed to represent a disease continuum. ³ Recent evidence suggests the loss of TDP-43 repression of cryptic splicing following nuclear...

... Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Cortical hyperexcitability is a key pathogenic feature of amyotrophic lateral sclerosis (ALS), believed to be mediated through complex interplay of cortical interneurons. To date, there has been no technological...

... comparison test). Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system with complex determinants, including genetic and non-genetic factors. A key pathological signature of ALS is the cytoplasmic mislocalization and aggregation of TDP-43 in affected motor neurons...

... for mitochondrial fusion, transport, maintenance and cell communication. MFN2 mutations are primarily linked to Charcot–Marie–Tooth disease type 2A. However, a few cases of amyotrophic lateral sclerosis and amyotrophic lateral sclerosis/frontotemporal dementia phenotypes with concomitant MFN2...

...-cytoplasmic trafficking. FUS amyotrophic lateral sclerosis nuclear lamina nuclear pore complex Correspondence to: Daisuke Ito, MD, PhD Department of Neurology/Memory Center, Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan E-mail: [email protected] Correspondence may also...