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Keywords: agonism
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Journal Article
Exploring the Potential Effect of GLP1R Agonism on Common Aging-Related Diseases via Glucose Reduction: A Mendelian Randomization Study
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Wei Jiang and others
The Journals of Gerontology: Series A, Volume 80, Issue 4, April 2025, glaf007, https://doi.org/10.1093/gerona/glaf007
Published: 11 January 2025
...Wei Jiang; Kaixi Ding; Maoyi Yang; Zhipeng Hu; Rensong Yue; Lewis A Lipsitz The present study intended to use Mendelian randomization (MR) to systematically explore the potential causal effects of proxy genetic variants of GLP1R agonism on 12 aging-related diseases and indicators. Compared...
Journal Article
Exploring Diverse Signaling Mechanisms of G Protein-Coupled Receptors through Structural Biology
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Ryoji Suno
The Journal of Biochemistry, Volume 175, Issue 4, April 2024, Pages 357–365, https://doi.org/10.1093/jb/mvae018
Published: 21 February 2024
... for future drug research and development. Here, we conduct a comparative examination of the structural details of various GPCR–signal transducer complexes and delve into the molecular basis of the currently proposed signal selectivity. Graphical Abstract Graphical Abstract GPCR bias agonism cryo-EM...
Journal Article
Relative size and chemical information impact mixed-sex contests in the crayfish Faxonius rusticus Girard, 1852 (Decapoda: Astacidea: Cambaridae)
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Sarah J Wofford-Mares and Paul A Moore
Journal of Crustacean Biology, Volume 43, Issue 4, December 2023, ruad082, https://doi.org/10.1093/jcbiol/ruad082
Published: 29 December 2023
... in the signal or how the participants use the information for assessment likely differs across the sexes. agonism assessment chemoreception Crustacea female assessment intersex fights While agonistic contests can convey access to vital resources, fighting behavior comes with inherent time and energy costs...
Journal Article
‘Listen Very Carefully, We Will Say This Only Once (Again)’ Dead Ends to Politicisation in Social Work
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Jan Naert and others
The British Journal of Social Work, Volume 54, Issue 5, July 2024, Pages 1889–1905, https://doi.org/10.1093/bjsw/bcad266
Published: 27 December 2023
... in the present. agonism critical social work dissenting social work politicisation prefigurative praxis Politicisation is back in social work. Recently a range of authors have (re)launched discussions about the political role of social work, squeezed in between ‘the death of social work’ ( Maylea, 2021...
Journal Article
The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans
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Liva S L Krogh and others
European Journal of Endocrinology, Volume 188, Issue 1, January 2023, Pages 48–58, https://doi.org/10.1093/ejendo/lvac015
Published: 10 January 2023
... as GIP(1-42). glucose-dependent insulinotropic polypeptide (GIP) GIP receptor agonism incretins GIP(1-30)NH2 Novo Nordisk Foundation 10.13039/501100009708 NNF18OC0034248 The naturally occurring C-terminally truncated variant of GIP, GIP(1-30)NH2, binds to the GIP receptor...
Journal Article
D2/D3 Receptor Agonism: Paving the Way for a New Therapeutic Target for Taste Disorders in Parkinson’s Disease and Other Conditions?
Elisa Mantovani and Stefano Tamburin
International Journal of Neuropsychopharmacology, Volume 25, Issue 11, November 2022, Pages 933–935, https://doi.org/10.1093/ijnp/pyac042
Published: 31 July 2022
..., placebo-controlled, clinical trials across several populations reporting gustatory symptoms. D2/D3 receptor agonism Parkinson’s disease pramipexole taste disorders treatment Chemosensory (i.e., olfaction and taste) function is mediated by highly specialized sensory systems with peripheral and central...
Journal Article
Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia
Anissa Abi-Dargham and others
Schizophrenia Bulletin, Volume 48, Issue 1, January 2022, Pages 199–210, https://doi.org/10.1093/schbul/sbab095
Published: 23 August 2021
... unknown and could include partial or full agonism, biased agonism, or positive allosteric modulation. Furthermore, the development of D1R targeting drugs has been complicated by complexities in extrapolating from in vitro affinity determinations to in vivo use. Prior D1R-targeted drugs have been...
Journal Article
Position Review: Functional Selectivity in Mammalian Olfactory Receptors
Barry W Ache
Chemical Senses, Volume 45, Issue 7, September 2020, Pages 503–508, https://doi.org/10.1093/chemse/bjaa046
Published: 29 June 2020
... the receptor in multiple distinct active conformations such that specific subsets of signaling effectors are engaged at the exclusion of others, creating a bias toward a particular outcome, which has been referred to as ligand-induced selective signaling, biased agonism, ligand-directed signaling...
Journal Article
In Vitro Impact of FSH Glycosylation Variants on FSH Receptor-stimulated Signal Transduction and Functional Selectivity
Teresa Zariñán and others
Journal of the Endocrine Society, Volume 4, Issue 5, May 2020, bvaa019, https://doi.org/10.1210/jendso/bvaa019
Published: 18 February 2020
...-stimulating hormone follicle-stimulating hormone receptor macroheterogeneity glycosylation signal transduction functional selectivity biased agonism FSH, or follitropin, is synthesized and secreted by the anterior pituitary gland in multiple molecular forms that vary in oligosaccharide number and type...
Journal Article
Beyond consensus: perceptions of risk from petroleum developments in Lofoten, Vesterålen, and Senja, Norway
Maiken Bjørkan and Siri Veland
ICES Journal of Marine Science, Volume 76, Issue 6, November-December 2019, Pages 1393–1403, https://doi.org/10.1093/icesjms/fsz056
Published: 09 April 2019
... outcomes, and assert that disagreement and partial victories and losses is a natural and healthy state of affairs in a democracy. agonism consensus deliberative democracy Lofoten Vesterålen and Senja petroleum discourse Q-methodology risk perception Over the last decade, the public debate signals...
Journal Article
Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity
Kelly A Berg and William P Clarke
International Journal of Neuropsychopharmacology, Volume 21, Issue 10, October 2018, Pages 962–977, https://doi.org/10.1093/ijnp/pyy071
Published: 06 August 2018
... understanding of drug-receptor interactions have occurred. This article highlights 2 of the major changes to pharmacology: inverse agonism and functional selectivity. Correspondence: William P. Clarke, PhD, Department of Pharmacology, Mail Stop 7764, UT Health at San Antonio, 7703 Floyd Curl Drive, San...
Journal Article
Large brains and groups associated with high rates of agonism in primates
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Veronica B. Cowl and Susanne Shultz
Behavioral Ecology, Volume 28, Issue 3, 01 May-June 2017, Pages 803–810, https://doi.org/10.1093/beheco/arx041
Published: 27 March 2017
... compete for resources is through agonism ( Sterck et al. 1997 ), an activity that is not only costly for an individual due to the direct risks of injury and in some extreme cases even death but also through the disruption of group stability and cohesion ( Cords 1992 ; Flack et al. 2006 ). Behaviors...
Journal Article
Response of the Formosan Subterranean Termite to Neighboring Con-Specific Populations After Baiting With Noviflumuron
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Sarah Bernard and others
Journal of Economic Entomology, Volume 110, Issue 2, April 2017, Pages 575–583, https://doi.org/10.1093/jee/tow317
Published: 28 February 2017
... or eliminated neighboring colony would provide insight on how best to manage areas of known termite infestation. Studies dealing with agonism between different populations of C. formosanus have been previously conducted using petri dish bioassays ( Su and Haverty 1991 , Cornelius and Osbrink 2003...
Journal Article
Marmoset Serotonin 5-HT1A Receptor Mapping with a Biased Agonist PET Probe 18F-F13714: Comparison with an Antagonist Tracer 18F-MPPF in Awake and Anesthetized States
Chihiro Yokoyama and others
International Journal of Neuropsychopharmacology, Volume 19, Issue 12, 1 December 2016, pyw079, https://doi.org/10.1093/ijnp/pyw079
Published: 08 September 2016
...-hydroxytryptamine Callithrix jacchus F13714 biased agonism Significance Statement Serotonin is a neurotransmitter substance in the brain that modulates numerous physiological functions, and the serotonin 1A receptor is a therapeutic target for neuropsychiatric and neurological disorders. Positron...
Journal Article
Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain
Maria Mavrikaki and others
International Journal of Neuropsychopharmacology, Volume 17, Issue 12, December 2014, Pages 1981–1993, https://doi.org/10.1017/S1461145714000728
Published: 23 May 2014
... and PD patients characterized by emotional deficits and suggest that altered NMDA-mediated neurotransmission in the limbic forebrain may underlie some of ropinirole's therapeutic actions. D3 receptor agonism Glutamate receptors IEGs Data were statistically analyzed using one-way analysis...
Journal Article
Insights into social relationships among female black howler monkeys Alouatta pigra at Palenque National Park, Mexico
Sarie Van BELLE and others
Current Zoology, Volume 57, Issue 1, 1 February 2011, Pages 1–7, https://doi.org/10.1093/czoolo/57.1.1
Published: 01 February 2011
... monkeys behave more similarly to female red howler monkeys A. seniculus than to female mantled howler monkeys A. palliata [Current Zoology 57 (1): 1 7, 2011]. Key words Black howler monkey, Alouatta pigra, Affiliation, Agonism, Female dispersal Relationships among female primates are generally explained...
Journal Article
Intra- and Interspecific Agonistic Behavior of the Subterranean Termite Microcerotermes crassus (Isoptera: Termitidae)
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Nellie Wong and Chow-Yang Lee
Journal of Economic Entomology, Volume 103, Issue 5, 1 October 2010, Pages 1754–1760, https://doi.org/10.1603/EC10060
Published: 01 October 2010
.... crassus
reached 100% in most of the interspeciÞc encounters. However, no or low mortality was recorded in
the intraspeciÞc pairings.
KEY WORDS Microcerotermes crassus, intraspeciÞc, interspeciÞc, agonism, survival
Microcerotermes crassus Snyder (Isoptera: Termiti- agonistic...
Journal Article
Agonistic Interactions Differ by Sex and Season in the Crayfish Orconectes Quinebaugensis
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Amy H. Warren and others
Journal of Crustacean Biology, Volume 29, Issue 4, 1 October 2009, Pages 484–490, https://doi.org/10.1651/08-3092.1
Published: 01 October 2009
... females having a more fights at maximum intensity than small females; this difference was not recapitulated in the reproductive season. These data indicate that investment in agonism differs by sex and by reproductive status, and the differential investment by sex in reproductive animals may indicate...
Journal Article
Specific in vitro toxicity of crude and refined petroleum products. 1. Aryl hydrocarbon receptor—mediated responses
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Cozmina M. Vrabie and others
Environmental Toxicology and Chemistry, Volume 28, Issue 9, 1 September 2009, Pages 1995–2003, https://doi.org/10.1897/08-624.1
Published: 01 September 2009
... of petroleum products and judge the necessity or priority of oil spill cleanup activities. Aryl hydrocarbon receptor Dioxin Petroleum hydrocarbons Agonism Antagonism As mentioned earlier, the potencies (as based on EC50 comparisons) of the oils tested were much lower compared to those of BaP...
Journal Article
Food limitation increases aggression in juvenile meerkats
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S.J. Hodge and others
Behavioral Ecology, Volume 20, Issue 5, September-October 2009, Pages 930–935, https://doi.org/10.1093/beheco/arp071
Published: 17 July 2009
... Drake A Fraser D Weary DM Parent-offspring resource allocation in domestic pigs Behav Ecol Sociobiol 2008 62 309 319 Drummond H The control and function of agonism in avian broodmates Adv Study Behav 2001 30 261 301 Drummond H A revaluation of the role...
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